Rchr
J-GLOBAL ID:200901069119315504   Update date: Sep. 20, 2024

Tachibana Keisuke

タチバナ ケイスケ | Tachibana Keisuke
Affiliation and department:
Other affiliations (1):
  • Osaka University  Graduate School of Pharmaceutical Sciences Drug Innovation Center 
Research field  (5): Pharmaceuticals - chemistry and drug development ,  Pharmacology ,  Pharmaceuticals - health and biochemistry ,  Cell biology ,  Molecular biology
Research keywords  (2): 核酸医薬 生活習慣病 核内受容体 ヒストン修飾酵素 分子生物学 細胞生物学 ,  nuclear hormane receptor
Research theme for competitive and other funds  (11):
  • 2021 - 2024 持続可能な超高齢化社会を実現 する認知症に対する予防医療戦 略の基盤構築
  • 2019 - 2022 患者フレンドリーな核酸医薬を実現する核酸経口剤化技術の新規基盤構築
  • 2018 - 2021 脂質センサー分子によるエネルギー消費と炎症制御を介したNASH治療戦略の構築
  • 2016 - 2019 Study on the activity of nuclear receptor PPAR delta that regulates energy expenditure
  • 2015 - 2018 Analysis of the transcriptional regulatory mechanism of nuclear receptors via posttranslational modification of the nuclear receptors and localization of the interacting factors
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Papers (72):
  • Kazuya Nagano, Tomohiro Nakao, Mariko Takeda, Haruna Hirai, Hikaru Maekita, Michiko Nakamura, Naoki Imakawa, Ayako Egawa, Toshimichi Fujiwara, Jian-Qing Gao, et al. Polyglycerol fatty acid ester contributes to the improvement and maintenance of water solubility of amorphous curcumin by suppressing the intermolecular interaction and the diffusion rate of curcumin. Food chemistry. 2024. 437. Pt 2. 137866-137866
  • Keisuke Tachibana, Ryuichi Hirayama, Naoyuki Sato, Kotaro Hattori, Takashi Kato, Hiroyuki Takeda, Masuo Kondoh. Association of Plasma Claudin-5 with Age and Alzheimer Disease. International journal of molecular sciences. 2024. 25. 3
  • Keisuke Tachibana, Lin Bai, Sayaka Sugimura, Hijiri Fujioka, Wataru Kishimoto, Hiroyuki Mizuguchi, Hiroshi Nakase, Masuo Kondoh. Heterogenous Gene Expression of Bicellular and Tricellular Tight Junction-Sealing Components in the Human Intestinal Tract. Biological & pharmaceutical bulletin. 2024. 47. 6. 1209-1217
  • 白 霖, 橘 敬祐, 村田 美治佳, 井上 哲利, 水口 裕之, 前田 真一郎, 池村 健治, 奥田 真弘, 日下部 哲也, 近藤 昌夫. ヒト腸管における食品中汚染物質および薬物の安全性評価モデルとしてのドキシサイクリン誘導CYP3A4発現Caco-2細胞株(A doxycycline-inducible CYP3A4-Caco-2 cell line as a model for evaluating safety of food contaminants and drugs in the human intestine). 日本臨床薬理学会学術総会抄録集. 2024. 44回. 1-5
  • Rina Hashimoto, Junya Takahashi, Keisuke Shirakura, Risa Funatsu, Kaori Kosugi, Sayaka Deguchi, Masaki Yamamoto, Yugo Tsunoda, Maaya Morita, Kosuke Muraoka, et al. SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression. Science advances. 2022. 8. 38. eabo6783
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MISC (70):
  • 高橋潤也, 橋本里菜, 高山和雄, 橘敬祐, 近藤昌夫, 近藤昌夫, 藤尾慈, 藤尾慈, 岡田欣晃, 岡田欣晃. Elucidation of the mechanism of endothelial barrier disruption by SARS-CoV-2 and identification of its inhibitors. 日本薬学会年会要旨集(Web). 2023. 143rd
  • 村岡康介, 白倉圭佑, 船津梨彩, 井上采人, 土井健史, 竹田浩之, 橘敬祐, 近藤昌夫, 藤尾慈, 岡田欣晃. Development of intracerebral drug delivery technology using Claudin-5 binding molecules. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
  • 松下俊介, 橘敬祐, 日下部哲也, 日下部哲也, 堤康央, 近藤昌夫. Regulatory Considerations of Conditional Approval for Balancing Pre-market and Post-market Evaluations to Achieve Early Patient Access to Medical Products in Japan. レギュラトリーサイエンス学会誌. 2021. 11. 2
  • 庄真喜子, 橘敬祐, 原田和生, 平田收正, 堤康央, 國澤純, 國澤純, 國澤純, 國澤純, 國澤純, et al. Current situation and challenges of a regulatory concept of pharmacokinetics focusing on microbiome. 腸内細菌学雑誌. 2021. 35. 2
  • 若山英里香, 橘敬祐, 竹田浩之, 近藤昌夫. Development of regulatory science platforms for the central nervous system. 日本薬学会年会要旨集(CD-ROM). 2020. 140th
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Professional career (1):
  • Ph.D. (Osaka University)
Awards (2):
  • 2007 - 日本薬学会近畿支部奨励賞
  • 2007 - The PSJ Kinki Branch Award for Young Scientists
Association Membership(s) (5):
日本蛋白質科学会 ,  日本生化学会 ,  日本分子生物学会 ,  The Japanese Biochemical Society ,  The Molecular Biology Society of Japan
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