Kimura Nobuyuki

キムラノブユキ | Kimura Nobuyuki

Affiliation and department：
Job title： Professor
Other affiliations (1)：

National Institutes of Biomedical Innovation, Health and Nutrition

Research field (5)： Experimental pathology , Cell biology , Veterinary medicine , Laboratory animal science , Neuroscience - general

Research keywords (2)： Nonhuman primates , 脳老化

Research theme for competitive and other funds (9)：

2022 - 2024 Establishment of blood-based biomarkers to reflect age-related changes in biological membrane
2017 - 2020 Development of a new mouse model to induce Alzheimer's pathology
2013 - 2016 Development and analysis of new Alzheimer's disease model mice which can reproduce age-related changes in brain.
2012 - 2014 Mechanism of transsynpatic retrograde transport in non-human primate model of ALS
2010 - 2012 Development of primate model of sporadic ALS with overexpression of TDP-43

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Papers (45)：

Tetsuhiro Ueda, Toshihide Takeuchi, Nobuhiro Fujikake, Mari Suzuki, Eiko N. Minakawa, Morio Ueyama, Yuzo Fujino, Nobuyuki Kimura, Seiichi Nagano, Akio Yokoseki, et al. Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD. Acta Neuropathologica Communications. 2024. 12. 1
Yoshiko Munesue, Naohide Ageyama, Nobuyuki Kimura, Ichiro Takahashi, Shunya Nakayama, Sachi Okabayashi, Yuko Katakai, Hiroshi Koie, Ken ichi Yagami, Kazuhiro Ishii, et al. Cynomolgus macaque model of neuronal ceroid lipofuscinosis type 2 disease. Experimental Neurology. 2023. 363
Sana Ando, Masashi Sakurai, Shusaku Shibutani, Nobuyuki Kimura, Nobuhiro Shimozawa, Yasuhiro Yasutomi, Ryotaro Yabe, Takashi Ohama, Koichi Sato. Age-related alterations in protein phosphatase 2A methylation levels in brains of cynomolgus monkeys: a pilot study. Journal of biochemistry. 2023
Shingo Koinuma, Nobuhiro Shimozawa, Yasuhiro Yasutomi, Nobuyuki Kimura. Aging induces abnormal accumulation of Aβ in extracellular vesicle and/or intraluminal membrane vesicle-rich fractions in nonhuman primate brain. Neurobiology of aging. 2021. 106. 268-281
Akira Ishiguro, Nobuyuki Kimura, Takashi Noma, Rieko Shimo-Kon, Akira Ishihama, Takahide Kon. Molecular dissection of ALS-linked TDP-43 - involvement of the Gly-rich domain in interaction with G-quadruplex mRNA. FEBS Letters. 2020. 594. 14. 2254-2265

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MISC (29)：

Nobuyuki Kimura, Katsuhiko Yanagisawa. Traffic jam hypothesis: Relationship between endocytic dysfunction and Alzheimer's disease. Neurochemistry International. 2018. 119. 35-41
羽田沙緒里, 木村彩乃, 木村展之, 池内健, 春日健作, 藁谷正明, 西村正樹, 鈴木利治. γセクレターゼ切断産物p3-Alcβペプチドの加齢およびAD発症による産生変化. Dementia Japan. 2018. 32. 3. 423-423
森原剛史, 佐藤真広, 赤津裕康, Paillard Luc, 木村展之, 鈴木利治, 数井裕光, 橋本亮太, 武田雅俊, 池田学. 脳内Aβ蓄積規定因子Kinesin Light Chain-1 variant E(KLC1vE). Dementia Japan. 2016. 30. 4. 562-562
森原剛史, 佐藤真広, 赤津裕康, 林紀行, Silverman Michael, Paillard Luc, 木村展之, 橋本亮太, 紙野晃人, 武田雅俊. Aβ脳蓄積の鍵の一つとなる遺伝子産物の同定とアルツハイマー病血中バイオマーカーの開発. 日本老年医学会雑誌. 2016. 53. Suppl. 127-128
木村展之, 上田直也, 富田泰輔, 柳澤勝彦. Presenilin-1の細胞内局在調節:RetromerとERADによる共役機構. 日本生物学的精神医学会(Web). 2016. 38th

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Education (3)：

2000 - 2004 The University of Tokyo Graduate School of Agricultural and Life Sciences Veterinary Medical Sciences
1996 - 2000 The University of Tokyo
1994 - 1996 The University of Tokyo

Professional career (1)：

獣医学博士 (東京大学)

Work history (6)：

2022/04 - 現在 Okayama University of Science
2020/08 - 2022/03 Japan Agency for Medical Research and Development
2013/01 - 2020/07 国立長寿医療研究センターアルツハイマー病研究部病因遺伝子研究室室長
2012/04 - 2012/12 医薬基盤研究所霊長類医科学研究センター主任研究員
2005/04 - 2012/03 National Institutes of Biomedical Innovation, Health and Nutrition

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Association Membership(s) (6)：

The Society of Primate Diseases and Pathology , JAPAN SOCIETY FOR BIOMEDICAL GERONTOLOGY , THE JAPANESE BIOCHEMICAL SOCIETY , 日本神経化学会 , 日本認知症学会 , 日本獣医学会

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