Research theme for competitive and other funds (20)：
2019 - 2022 Studies on the opening mechanism of tight junction by MA026
2016 - 2019 Chemical biological study using gamma-tubulin specific inhibitor, gatastatin
2013 - 2016 Development of agrochemical and pharmaceutical lead compounds based on the search and total synthesis of natural compounds with a unique structure and biological activity
2013 - 2016 Molecular mechanisms of signaling pathways regulating inflammatory responses and their elucidation by bioprobes
2011 - 2016 Target Identification of bioactive small molecules
2012 - 2014 Construction of screening system and screening of novel tight junction inhibitors
2010 - 2012 Total synthesis and investigation of biologically active natural compounds with novel and complex structures and its application to the development of agricultural and pharmaceutical lead compounds
2009 - 2010 アクチン・アクチン結合蛋白質相互作用を阻害する小分子化合物の解析
2008 - 2010 Target identification of vauolating compound, vicenistatin.
2005 - 2009 Chemical proteomics to reveal interaction between chemicals and proteins at angstrom level
2007 - 2008 チューブリン・微小管結合蛋白質相互作用を阻害する低分子化合物の解析
2006 - 2007 Synthesis and Biological Evaluation of Spiroketal Derivatives
2004 - 2006 Analysis of interaction between microtubule-associated protein/microtubule-targeting agents and single allele tubulin.
2004 - 2005 Synthesis and Biological Evaluation of Antifungal Antibiotics, Spirofungin A and B
2002 - 2003 Studies for Structure-Activities Relationships of Reveromycin A : An Inhibitor of Eukaryotic Cell Growth
2000 - 2002 Chemical biology study on protein phosphatases and their specific inhibitors.
1997 - 2000 Isolation and mechanism study of cell cycle inhibitors from microbial metabolites.
1998 - 1998 デュアルスペシフィックホスファターゼの阻害剤開発と機能探索
1997 - 1997 デュアルスペシフィックホスファターゼの阻害剤開発と機能探索
Show all
Papers (130)：
Honma, Sota, Kimishima, Aoi, Kato, Satoshi, Horiuchi, Akari, Hokari, Rei, Honsho, Masako, Kojima, Hiroki, Tokiwa, Toshiyuki, Sugawara, Akihiro, Iwatsuki, Masato, et al. The isolation of sclerotinin A as an anti-malarial compound by utilization of a global secondary metabolism regulator, laeA gene. Bioorganic Medicinal Chemistry Letters. 2024. 113
Kimishima, Aoi, Nishitomi, Atsuka, Tsuruoka, Iori, Sakai, Katsuyuki, Hokari, Rei, Honsho, Masako, Honma, Sota, Ono, Yuki, Kondo, Naozumi, Tsutsumi, Hayama, et al. Discovery of an anti-malarial compound, burnettiene A, with a multidrug-sensitive Saccharomyces cerevisiae screening system based on mitochondrial function inhibitory activity. Bioscience, biotechnology, and biochemistry. 2024. Epub
Kimishima, Aoi, Nishitomi, Atsuka, Kondo, Naozumi, Honma, Sota, Honsho, Masako, Negami, Sota, Maruyama, Serino, Taguchi, Kazuki, Matsui, Hidehito, Hanaki, Hideaki, et al. Isolation of microorganisms from the feces of Kitasato Yakumo beef cattle as bioactive natural product producers. Bioscience, biotechnology, and biochemistry. 2024. Epub
Sota Honma, Aoi Kimishima, Atsushi Kimishima, Masako Honsho, Hiroki Kojima, Toshiyuki Tokiwa, Atsuka Nishitomi, Satoshi Kato, Naozumi Kondo, Yasuko Araki, et al. Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitive Saccharomyces cerevisiae screening system and the introduction of a global secondary metabolism regulator, laeA gene. Bioscience, Biotechnology, and Biochemistry. 2024
Salarinejad, Somayeh, Seyfi, Soheila, Hayashi, Seiko, Moghimi, Setareh, Toolabi, Mahsa, Taslimi, Parham, Firoozpour, Loghman, Usui, Takeo, Foroumadi, Alireza. Design, synthesis, and biological evaluation of new biaryl derivatives of cycloalkyl diacetamide bearing chalcone moiety as type II c-MET kinase inhibitors. MOLECULAR DIVERSITY. 2024. Epub
1992 - 1995 The University of Tokyo Graduate School, Division of Agricultural Science
1990 - 1992 The University of Tokyo Graduate School, Division of Agricultural Science
1986 - 1990 The University of Tokyo Faculty of Agriculture
Work history (8)：
2022/04 - 現在 筑波大学 Degree Program in Life and Agricultural Sciences Program Leader
2018/04 - 現在 University of Tsukuba Faculty of Life and Environmental Sciences Professor
2006/09 - 2018/03 University of Tsukuba Associate Professor
2005/04 - 2006/08 RIKEN institute Senior Researcher
1995/10 - 2004/03 RIKEN institute Researcher
2002/03 - 2003/04 Paterson Cancer Research Institute (Manchester, Great Britain) Postdoctrol fellow
2001/10 - 2002/02 Beatson Cancer Research Institute (Glasgow, Great Britain) Postdoctrol fellow
1994/04 - 1995/09 JSPS Research Fellow
Show all
Committee career (4)：
2013/04 - 現在 新薬創製談話会 常任幹事
2020/05 - 2024/05 日本農芸化学会 関東支部/代議員
2020/10 - 2021/11 第94回日本生化学会年会 実行委員会委員
2019/10 - 2021/10 酵母合同シンポジウム 実行委員会委員
Awards (7)：
2018/03 - 日本農芸化学会 トピックス賞
2016/03 - 日本農芸化学会 日本農芸化学会 第13回農芸化学研究企画賞
2012/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry Award for Excellence to Authors Publishing in Bioscience, Biotechnology, and Biochemistry
2011/03 - 日本農芸化学会 日本農芸化学会 トピックス賞
2007/03 - Japanese Society for Bioscience, Biotechnology, and Agrochemistry Award for Excellence to Authors Publishing in Bioscience, Biotechnology, and Biochemistry
2005/03 - 日本農芸化学会 日本農芸化学会 農芸化学奨励賞
2004/05 - 日本がん分子標的治療研究会 日本がん分子標的治療研究会 研究奨励賞
Show all
Association Membership(s) (4)：
THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER
, The Molecular Biology Society of Japan
, THE JAPANESE BIOCHEMICAL SOCIETY
, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY
