Rchr

J-GLOBAL ID：200901069757135777 Update date: Apr. 02, 2024

Yoshioka Kazuaki

ヨシオカカズアキ | Yoshioka Kazuaki

Affiliation and department：
Job title： Associate Professor

Research field (4)： Pathobiochemistry , Cell biology , Molecular biology , Physiology

Research keywords (17)：ノックアウトマウス , 低分子量Gタンパク質 , ライブセルイメージング , ホスホイノシチド , 血管内皮細胞 , PI3 kinase , Autophagy , Endocytosis , Membrane Trafficking , シグナル伝達 , 血管平滑筋 , 心血管障害 , 血管新生 , Signal transduction , contruction-relaxation Smooth muscle cell , Cardiovascular remodeling , Angiogenesis

Research theme for competitive and other funds (42)：

2022 - 2025 大血管手術後の脊髄虚血に関するバイオマーカーの測定と探索
2021 - 2024 大伏在静脈周囲組織がグラフト血管内皮機能に与える影響に関する研究
2020 - 2023 スフィンゴシン1-リン酸産生を起点とした新規熱産生機構の解明と肥満治療への応用
2020 - 2023 Physiological functions of alveolar stem cell through intracellular clearance by lipid phosphatase
2021 - 2022 血管内皮の特殊オートファジー経路を介したウイルス感染制御機構

2017 - 2020 Physiological roles of Phosphoinositide-specific phosphatase in lung development and maturation through regulating membrane trafficking.

2018 - 2019 エンドソーム膜受容体シグナリングを標的とする難治血管病治療戦略の開発

2014 - 2017 Regulation of membrane trafficking through PI(3)P-metabolizing enzymes in endothelial cells.

2014 - 2016 Pathophysiology of phosphoinositide-metabolizing enzymes for maintaining vascular homeostasis

2014 - 2015 イノシトールリン脂質代謝酵素を標的とした心不全治療薬開発の基盤研究

2014 - 2015 腫瘍血管新生阻害治療開発に貢献する新規モデルマウスの開発

2013 - 2015 Control of vascular barrier integrity by MTM family of phosphatidylinositol 3-phosphate phosphatase

2013 - 2015 血管健常性を維持する新規内皮発現分子の病態生理研究

2012 - 2015 Mechanisms for the regulation of vascular homeostasis by functional lipid molecules

2013 - 2014 脂質代謝酵素ネットワークによる血管バリア機能維持機構の解明

2013 - 2014 血管恒常性維持を担うクラスIIα型PI3キナーゼC2αの細胞内メンブレン・トラフィック調節機構

2013 - 2014 イノシトールリン脂質代謝酵素を標的とした動脈硬化治療法の開発

2013 - 2014 クラスII型PI3キナーゼC2αによる血管恒常性維持機構の解明

2013 - 2014 脂質キナーゼPI3K-C2α酵素の血管恒常性維持機構の解明

2013 - 2014 クラスII 型PI3 キナーゼC2αによる血管バリア機能維持機構の解明 - 解離性大動脈瘤発症メカニズムの解明に向けて -

2013 - 2014 クラスII型PI3キナーゼC2αによる血管形成・健全性維持の機能解析

2012 - 2013 血管形成・恒常性維持におけるクラスII型PI3キナーゼC2αの生理的役割

2011 - 2013 Class II PI3 kinase C2alpha has an essential role in angiogenesis and vascular homeostasis through regulating endosomal trafficking

2011 - 2012 Disruption of vascular integrity by deficiency of PI3K class II αisoform in mice

2011 - 2011 腫瘍血管新生阻害治療の分子標的探索に有用な新規マウスモデルの開発

2010 - 2011 健康な血管を維持する新しい細胞内シグナル分子II型PI3キナーゼαの機能解析

2010 - 2011 解離性大動脈瘤の病態解明および治療法開発に貢献する新規なマウスモデルの開発

2009 - 2011 Role of functionallipids in cardiovascular homeostasis and diseases

2008 - 2010 Mechanistic analysis of blood vessel formation in class II PI3 kinase C2・ knockout mouse

2006 - 2009 Development of regenerative therapy for vascular formation using sphingosine-1-phosphate

2005 - 2009 Signaling for regulating hematogenous metastasis of tumors

2005 - 2006 Interrated research on the physiological role ofbioactive sphingosine-1-phosphate and Edg receptors by using genetically engineered maice.

2004 - 2005 分化型血管平滑筋細胞を用いた定量的収縮評価法の開発及び新規収縮シグナル分子の同定

2004 - 2005 Regulation of calcium sensitization of vascular smooth muscle contraction by strech

2004 - 2004 G蛋白共役型受容体による癌の浸潤・転移の制御とその分子メカニズム

2003 - 2004 Molecular dissection of the physiological role of bioactive sphingosine-1-phosphate and Edg receptors

2003 - 2003 Molecular mechanisms of tumor metastasis and transition by G-protein-coupled receptors

2001 - 2002 アデノシン受容体と神経機構

2001 - 2002 Molecular biological analysis of the lipid morphogen sphingosine-1-phosphate

2002 - Regulation of contraction of vascular smooth muscle cells by mechanical stimulus

1998 - 2001 新しいプリン受容体タンパク質の構造と機能の研究

Study of physiological role of cardiovascular remodeling using knockout mouse.

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Papers (78)：

Tazbir Ahmed, Takafumi Suzuki, Ryo Terao, Reiko Yamagishi, Ryosuke Fujino, Kunihiro Azuma, Hirotsugu Soga, Takashi Ueta, Megumi Honjo, Sumiko Watanabe, et al. Roles of Sphingosine Kinase and Sphingosine-1-Phosphate Receptor 2 in Endotoxin-Induced Acute Retinal Inflammation. Ocular Immunology and Inflammation. 2023. 1-15
Jun-ichi Morishige, Kazuaki Yoshioka, Hiroki Nakata, Kazuhiro Ishimaru, Naoto Nagata, Tamotsu Tanaka, Yoh Takuwa, Hitoshi Ando. Sphingosine Kinase 1 is Involved in Triglyceride Breakdown by Maintaining Lysosomal Integrity in Brown Adipocytes. Journal of Lipid Research. 2023. 100450-100450
Yushin Mizuno, Junsuke Nakase, Kazuaki Yoshioka, Takuya Sengoku, Rikuto Yoshimizu, Tomoyuki Kanayama, Yusuke Yanatori, Hiroyuki Tsuchiya. Differences in collagen types in the semitendinosus, quadriceps, and patellar tendons: A report using samples from an 11-year-old patient. Knee. 2023. May. 4. 339-346
Kano, Hiroshi, Izumi, Kouji, Hiratsuka, Kaoru, Toriumi, Ren, Nakagawa, Ryunosuke, Aoyama, Shuhei, Kamijima, Taiki, Shimada, Takafumi, Naito, Renato, Kadomoto, Suguru, et al. Suppression of androgen receptor signaling induces prostate cancer migration via activation of the CCL20-CCR6 axis. Cancer Science. 2023. 114. 4. 1479-1490
Kazuki Asai, Junsuke Nakase, Kazuaki Yoshioka, Rikuto Yoshimizu, Mitsuhiro Kimura, Hiroyuki Tsuchiya. Adipose-Derived Stem Cell Sheets Promote Meniscus Regeneration Regardless of Whether the Defect Involves the Inner Half or the Whole Width of the Anterior Half of the Medial Meniscus in a Rabbit Model. Arthroscopy. 2022. 38. 9. 2672-2683

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MISC (53)：

YOSHIOKA Kazuaki. Dragonfly and Andor cameras the perfect combination of speed, resolution and sensitivity to image vesicle trafficking in live cells. Application Note(Oxford Instruments, Andor). 2019
吉岡和晃, Quynh Hoa Pham, 多久和陽. エンドリソソーム、オートファジーの機能を調節するイノシトールリン脂質3‘-ホスファターゼ・MTMR4. 月刊「細胞」北隆館・ニューサイエンス社. 2019. 51. 9. 454-457
Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Toshishige Shibamoto, Yoh Takuwa. S1P(2), A RECEPTOR FOR THE LYSOPHOSPHOLIPID MEDIATOR SPHINGOSINE 1-PHOSPHATE, PROTECTS AGAINST VASCULAR BARRIER DISRUPTION. SHOCK. 2016. 46. 4. 28-28
Saori Koizumi, Kazuaki Yoshioka, Sho Aki, Yoh Takuwa. Phosphatidylinositol 3-kinase class II α isoform (PI3K-C2α) maintains vascular integrity. The Juzen Medical Society Kanazawa University. 2016. 125. 2. 77-78
吉田耕太郎, 奥村健一朗, 井上大, 南哲弥, 香田渉, 蒲田敏文, 安藝翔, 吉岡和晃, 多久和陽. ICGを用いたマウスリアルタイム光音響イメージングの検討(Usefulness of indocyanine green contrast agent for photoacoustic imaging in an in vivo mouse model). JSMI Report. 2016. 9. 2. 169-169

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Patents (1)：

非ヒトノックアウト動物、並びにその用途およびその作製方法

Books (2)：

Bioactive Lipid Mediators. Yokomizo T., Murakami M. (eds)
Springer 2015 ISBN:9784431556695
Methods in Signal Transduction Series “G Protein-Coupled Receptors: Structure, Function, and Ligand Screening” Editors: Haga, T. and Takeda, S
CRC Press 2005 ISBN:0849327717

Lectures and oral presentations (163)：

New pathophysiology of human aortic dissection through single-cell RNA-seq analysis
(KitaKyushu International Conference Center, West Japan General Exhibition Center 2024)
Single cell RNA-sequencing analysis of the human aortic diseases
(2023)
Single-cell RNA-sequencing analysis of the vascular remodeling in human dissecting aorta
(Fukuoka International Congress Center, MARINE MESSE FUKUOKA Hall B 2023)
クラスII-PI3キナーゼによるエンドサイトーシス制御を介した血管平滑筋収縮調節機構
(第63回日本脂質生化学会 2021)
Sphingosine kinase-2 is required for autophagic lipid degradation in macrophage and inhibits atherosclerosis
(2020)

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Education (3)：

1994 - 1998 Tokyo University of Agriculture and Technology Graduate School of Engineering Doctoral program, Division of Materials Science and Biotechnology
1992 - 1994 Tokyo University of Agriculture and Technology Graduate School of Engineering Master's program, Division of Materials Science and Biotechnology
1990 - 1992 Tokyo University of Agriculture and Technology Faculty of Engineering Department of Industrial Chemistry

Professional career (1)：

Ph.D. (Tokyo University of Agriculture and Technology)

Work history (6)：

2022/11 - 現在 Kanazawa University Department of Physiology, Institute of Medical, Pharmaceutical and Health Sciences Faculty of Medicine Associate Professor
2017/07 - 2022/10 Kanazawa University Department of Physiology, Institute of Medical, Pharmaceutical and Health Sciences Faculty of Medicine Associate Professor
2002/04 - 2017/06 Kanazawa University Department of Physiology, Faculty of Medicine, Graduate School of Medical Science Assistant Professor
2001/01 - 2002/03 Japan Science and Technology Agency : Tokyo Metropolitan Institute for Neuroscience Science and Technology Research Fellow
1999/10 - 2000/12 Tokyo Metropolitan Institute for Neuroscience Department of Neurochemistry Research associate (Post-doc)

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Awards (18)：

2018 - SENSIN Medical Research Foundation Research Grant
2014 - The HOKKOKU Cancer Foundation 28th Research Grant
2014 - Ono Medical Research Foundation 27th Ono Medical Research Grant
2013 - Gordon Research Conference 2013 Vascular Cell Biology Travel scholarship "Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function."
2013 - SUZUKEN Memorial Foundation Research Grant

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Association Membership(s) (4)：

日本生化学会 , 日本生理学会 , THE JAPANESE CONFERENCE ON THE BIOCHEMISTRY OF LIPIDS , 日本血管生物医学会

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