2020 - 2023 Development of minimally invasive therapy for oral cancer by hyperthermia with tumor-specific targeting magnetic nanoparticles
2020 - 2023 Elucidation of selective cytotoxicity against malignant cells by chromone derivatives
2016 - 2019 Clarification of the role of CD13 combined with N-terminal fragment of fibronectin on inflammatory bone resorption.
2013 - 2016 Identification of stromal cell-derived factors required for maintaining functional osteoclast precursors and elucidation of the role of the factors in inflammatory bone destruction
2010 - 2012 Investigation of the role of endogenous Wnt signaling in osteoclast differentiation and function
2005 - 2006 A drug development study for a periodontal disease : Biological properties of synthetic lipid A of Porphyromonas gingivalis lipopolysaccharide
2004 - 2006 Proteome analysis of phosphorylated proteins associated with osteoclast formation using established osteoclast precursor cell line
2004 - 2005 Apoptosis induced by butyric acid modulates immunoresponses : Role of epitherial cells and fibroblasts in inhibiting butyric acid-induced T cell apoptosis
1993 - 2004 Purification and identification of factors involved in osteoclastic maturation from bovine bone matrix
2002 - 2003 遺伝子導入法を用いた線維芽細胞によるT細胞アポトーシス解除機序の解明
2002 - 2003 Effects of adhesion molecules and mechanism of gingival fibroblast rescue butyric acid-induced T-cell apoptosis.
2001 - 2002 The study of an effect of Porphyromonas gingivalis heat shock protein on bone resorption
1999 - 2000 Identification and application of functional active domain of P.gingivalis fimbriae
1999 - 2000 Regulatory mechanism of expression of ODF and OCIF genes in P.gingivalis LPS-induced bone resorption.
1997 - 1997 破骨細胞の骨吸収機能発現におけるシスエレメントE-boxの役割
1997 - 破骨細胞の骨吸収機能発現におけるシスエレメントE?boxの役割
1995 - 1996 Role of basic helix-loop-helix SCL protein in osteoclast differentiation
1993 - 1994 Purification and identification of factors involved in osteoclastic maturation from bovine bone matrix
1992 - 1993 Gene expression of inflammatory cytokines in periodontal tissues and network of thier cytokines
1992 - 1992 Porphyromonas gingivalis線毛による骨吸収刺激作用
1990 - 1991 Regulation of Cytokines for Gene Expression and Function of Gingival Fibroblasts
1991 - Study on the mechanisms involved in bone resorption of periodontal disease
1990 - Study on the differentiation of osteoclast
1989 - 1989 培養骨細胞由来の前破骨細胞の樹立化に関する研究
1985 - 1987 Application for diagnosis of B.gingivalis-specific monoclonal antibody in periodontal disease.
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Papers (72)：
Shigeru Amano, Masaru Matsumoto, Masanori Morimoto, Hirokazu Kawamoto, Fumiaki Takeshita, Toshikazu Yasui, Hiroshi Sakagami. Efficacy of toothpaste containing Brazilian green propolis extracts with an optimal kaempferide/betuletol ratio for improving oral microbiota: A randomized, controlled, paired crossover study. Journal of Ethnopharmacology. 2024. 118762-118762
MEGUMI INOMATA, MASAYO ABE, YASUKO KAWASE, TORU HAYASHI, SHIGERU AMANO, HIROSHI SAKAGAMI. Dectin-1/SYK Activation Induces Antimicrobial Peptide and Negative Regulator of NF-κB Signaling in Human Oral Epithelial Cells. In Vivo. 2024. 38. 3. 1042-1048
YUSEI OTAKA, MAKI IZAWA, HIROSHI SAKAGAMI, NORIYOSHI SHIBA, NOBUTOSHI TAKAHASHI, SEI-ICHI TANUMA, SHIGERU AMANO, SHIN UOTA, MEGUMI INOMATA, SATOSHI YOKOSE, et al. UVC-Protective Activity of Lemongrass Among 12 Fat-soluble Herbal Extracts: Rapid Decay Due to Cytotoxicity. In Vivo. 2023. 37. 6. 2464-2472
Megumi Inomata, Shigeru Amano, Masayo Abe, Toru Hayashi, Hiroshi Sakagami. Innate immune response of human periodontal ligament fibroblasts via the Dectin-1/Syk pathway. Journal of Medical Microbiology. 2022. 71. 12
Aruna Chhikara, Praveen K. Roayapalley, Hiroshi Sakagami, Shigeru Amano, Keitaro Satoh, Yoshihiro Uesawa, Umashankar Das, Swagatika Das, Edgar A. Borrego, Cristina D. Guerena, et al. Novel Unsymmetric 3,5-Bis(benzylidene)-4-piperidones That Display Tumor-Selective Toxicity. Molecules. 2022. 27. 19. 6718-6718
飯島洋介, 天野滋, 坂東健二郎, 佐野元彦, 仲山奈見, 山田美喜, 日野峻輔, 金子貴広, 堀江憲夫, 坂上宏. Protection of bortezomib-induced neurotoxicity by antioxidants. Journal of Oral Biosciences Supplement (Web). 2020. 2020
Evaluation of Biological Activity of Mastic Extracts Based on Chemotharapeutic Indices. In Vivo : International Journal of Experimental and Clinical Pathophysiology of Drug Research. 2017. 31. 4. 591-598
