Rchr
J-GLOBAL ID：200901070988046333
Update date: Jan. 14, 2025
Maruyama Toru
マルヤマ トオル | Maruyama Toru
Affiliation and department：
Job title：
Professor
Research field (1)：
Clinical pharmacy
Research theme for competitive and other funds (28)：
- 2021 - 2024 急性相蛋白質オロソムコイドによる蛋白尿抑制の分子基盤解明と慢性腎臓病治療への応用
- 2020 - 2024 網羅的アルブミン翻訳後修飾解析に基づくCKD病態生理解明と診断・治療戦略への展開
- 2020 - 2022 Development of Biomimetic DDS to improve healthy longevity and its application to the treatment for sarcopenia
- 2018 - 2021 Development of a renal carbon monoxide delivery system for treatment of lethal rhabdomyolysis
- 2016 - 2020 Treatment strategy based on the pathophysiology of renal-multi-organ axis induced by pathogenic albumin
- 2016 - 2018 Development of highly sensitive imaging method by use of functional single-chain antibodies that discriminate the structure of advanced glycation endproduct
- 2016 - 2018 Treatment strategy for kidney disease based on TLR4-macrophage control by alfa1-acid glycoprotein
- 2015 - 2018 Protein-bound uremic toxins-induced functional abnormalities of HDL cholesterol for prevention of atherosclerosis accelerated by chronic kidney disease
- 2015 - 2018 The role of remote ischemic preconditioning in contrast induced nephropathy
- 2015 - 2018 Development of transport system of NO and H2S based on Human serum albumin
- 2015 - 2018 Development of renal delivery system for hybridized tissue regenerating factors and its application for kidney disease
- 2015 - 2018 Development of ultrasound-responsive nanobubbles containing physiologically active gas and construction of disease treatment system
- 2015 - 2017 Development of new treatment against invasive fungal infection by S-nitrosated protein
- 2015 - 2017 Development of a novel carrier for tumor associated macrophage and its application to cancer immunotherapy
- 2014 - 2017 Novel antioxidant therapy for radiation-induced injuries
- 2013 - 2016 Molecular mechanism of transportsome in chronic kidney disease and the involvement of thyroid hormone
- 2013 - 2016 Strategy for the personalized CKD medicine based on the crosstalk between albumin-bound uremic toxin and kidney
- 2013 - 2015 Construction of an Innovative Bone Marrow Delivery System of Anticancer Drug for Control of Malignant Tumors' Bone Metastasis
- 2012 - 2015 Design and Evaluation of Next Generation Albumin-thioredoxin Fusion Protein for Multiple Organ Failure Treatment
- 2012 - 2014 S-Nitrosated Alpha-1-acid Glycoprotein Kills Drug-resistant Bacteria and Aids Survival in Sepsis
- 2011 - 2014 The NO conjugated-albumin nanoparticles for the application to multidisciplinary cancer treatment
- 2011 - 2012 Development of effective blood purification treatment method usingHSA bound toxic comnpodus designed bpyhase display tecnohlogy
- 2009 - 2011 Development of Redox Controlling Nanomedicine Based on Albumin Fusion
- 2009 - 2010 Aβペプチド捕獲型アルブミン製剤の開発とアルツハイマー病治療への応用
- 2008 - 2010 Strategy for the personalized medicine of molecular target drug based on the polymorphism information of plasma protein
- 2007 - 2008 毒素捕獲型アルブミン変異体による安全な肝移植を目指した新規血液浄化法の開発
- 2006 - 2008 Application of functional recombinant HSAs as a DDS carrier
- 2006 - 2007 Mapping of drug binding sites on al-acid glycoprotein
Show all
Papers (380)：
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Hiroki Yanagisawa, Hitoshi Maeda, Isamu Noguchi, Motohiko Tanaka, Naoki Wada, Taisei Nagasaki, Kazuki Kobayashi, Gai Kanazawa, Kazuaki Taguchi, Victor Tuan Giam Chuang, et al. Carbon monoxide-loaded red blood cells ameliorate metabolic dysfunction-associated steatohepatitis progression via enhancing AMP-activated protein kinase activity and inhibiting Kupffer cell activation. Redox Biology. 2024. 76. 103314-103314
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Kai Tokumaru, Tadashi Imafuku, Takao Satoh, Tomoaki Inazumi, Shu Hirashima, Ayano Nishinoiri, Taisei Nagasaki, Hitoshi Maeda, Yukihiko Sugimoto, Motoko Tanaka, et al. Omega 3 Fatty Acids Attenuate the Acute Kidney Injury to CKD Transition and Renal Fibrosis: Identification of Antifibrotic Metabolites. Kidney360. 2024
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Kazuaki Taguchi, Mai Hashimoto, Masahiro Tokuno, Shinji Takeoka, Toru Maruyama, Keishi Yamasaki, Masaki Otagiri. Qualitative and quantitative status of cytochrome P450s after the administration of a liposomal platelet substitute in rat liver. Xenobiotica; the fate of foreign compounds in biological systems. 2024. 1-7
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Yuka Nakamura, Hiroshi Watanabe, Teruya Nakamura, Mami Chirifu, Kana Ishiodori, Tadashi Imafuku, Hitoshi Maeda, Yoshihiro Kobashigawa, Hiroshi Morioka, Toru Maruyama. Contribution of Phe112, Ser114, and Tyr115 to Drug-Binding Selectivity in the A Variant of α1-Acid Glycoprotein. Molecular Pharmaceutics. 2024
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Yuka Nakamura, Hiroshi Watanabe, Tadashi Imafuku, Issei Fujita, Yuto Ganaha, Toru Takeo, Naomi Nakagata, Hitoshi Maeda, Toru Maruyama. Contribution of the α1-Acid Glycoprotein in Drug Pharmacokinetics: The Usefulness of α1-Acid Glycoprotein-Knockout Mice. Molecular pharmaceutics. 2024
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MISC (228)：
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金澤雅緯, 前田仁志, 安田健吾, 渡邊博志, 丸山徹. ヒト血清アルブミンを基盤とした抗酸化ナノDDS戦略の構築と筋疾患治療への応用. 人工血液. 2024. 32. 1
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安田健吾, 前田仁志, 木下遼, 水田夕稀, 渡邊博志, 丸山徹. 血清アルブミンを基盤としたレドックス応答性ナノ抗酸化剤の開発. 医療薬学フォーラム講演要旨集. 2024. 32nd
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金澤雅緯, 前田仁志, 安田健吾, 渡邊博志, 丸山徹. Development of skeletal muscle targeting nano-radical scavenger based on human serum albumin and its therapeutic potential against sarcopenia. 日本薬剤学会年会講演要旨集(CD-ROM). 2023. 38th
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福田涼, 福田涼, 前田仁志, 藤原章雄, 渡邊博志, 菰原義弘, 丸山徹. リンパ節マクロファージのCD169を標的とした新規がん免疫療法の開発. 日本DDS学会学術集会プログラム予稿集. 2023. 39th
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Ishima Yu, Maruyama Toru, Otagiri Masaki, Chuang Victor T G, Ishida Tatsuhiro. The new delivery strategy of albumin carrier utilizing the interaction with albumin receptors. Chemical & Pharmaceutical Bulletin. 2022. Vol.70. No.5. 330-333
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Books (3)：
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タンパク結合率の臨床的な意義を教えて下さい
月刊薬事 3月号 2016
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CKD-MBDにおけるリン吸着薬の進歩と治療選択〜リンと鉄の関連を含めて〜
最新透析医療 先端技術との融合 医薬ジャーナル社 2016
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Albumin as a biomarker. Human serum albumin: Pharmaceutical and medical applications
Springer 2016
Lectures and oral presentations (360)：
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注目すべき加齢性疾患~サルコペニアと骨代謝以上の成因と治療戦略~
(日本薬学会第136年会 2016)
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ヒト血清アルブミンにおける活性イオウ分子種の検出と構造・機能への影響
(日本薬学会第136年会 2016)
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慢性腎臓病における腎-多臓器連関に関わる尿毒素の関与とその分子機構
(日本薬学会第136年会 2016)
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腎指向型アルブミン-BMP7 ハイブリッド体の創製と腎保護効果の検討
(第6回 腎不全研究会 2015)
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副甲状腺ホルモンよるABCG2 の発現抑制は二次性副甲状腺機能亢進症における尿酸値の上昇に関与する
(第6回 腎不全研究会 2015)
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Works (3)：
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ハイブリッド化臓器再生因子の腎送達システムの構築と次世代型腎疾患治療薬への応用
2015 - 2018
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腫瘍関連マクロファージの標的化による効率的表現型転換を基盤とした革新的癌免疫療法
2015 - 2017
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α1ー酸性糖タンパク質分子上における薬物結合部位のマッピング
2006 - 2008
Education (4)：
- - 1990 Kumamoto University
- - 1990 Kumamoto University Graduate School, Division of Pharmaceutical Sciences
- - 1985 Kumamoto University School of Pharmacy
- - 1985 Kumamoto University Faculty of Pharmaceutical Science
Work history (2)：
- 2006 - Kumamoto University School of Pharmacy
- 2006 - Professor, ,School of Pharmacy,Kumamoto University
Association Membership(s) (5)：
日本薬剤学会
, 日本プライマリーケア学会
, 日本医療薬学会
, 日本薬物動態学会
, 日本薬学会
