Rchr

J-GLOBAL ID：200901071080779197 Update date: Sep. 28, 2024

Saito Izumu

サイトウイズム | Saito Izumu

Affiliation and department：
Other affiliations (1)：

Professor Emeritus, The University of Tokyo

Research keywords (6)： genome editing , adenovirus vector , hepatitis B virus , multiplex guide RNAs , gene therapy , SARS-CoV-2

Research theme for competitive and other funds (40)：

2019 - 2022 ゲノム編集用一体型アデノベクターとヒト型マウスの開発による遺伝子治療モデルの構築
2016 - 2019 Establishment of humanized mice as a small animal model for measles virus infection
2016 - 2019 HBVゲノムを多数同時切断し破壊する多重ガイドRNA発現アデノベクター及びモニター用蛍光誘導HBVゲノムの開発
2015 - 2018 Search for new potential drug targets for Hepatitis B virus genome replication based on chemical biology
2014 - 2017 A basic research to elucidate the mechanism of preconditioning against ischemia-reperfusion injury and its therapy

2014 - 2016 Visualization of replicating genome of hepatitis B virus: development of the method for alpha-Cre complementation and frame overlap

2010 - 2016 Comprehensive Brain Science Network

2011 - 2013 Improvement of helper-dependent adenovirus vector not only increasing gene expression but also cell/tissue specificity

2011 - 2013 A diversified approach to investigate the mechanism of acute lung injury and to establish its therapeutic strategy

2005 - 2009 Development of adenovirus vectors and expression systems aiming cancer therapy

2004 - 2009 New therapeutic strategies for treatment of cancer based on basic research

2004 - 2005 Development of novel method for the construction of viral vectors using the site-specific recombinase

2000 - 2004 がん治療をめざしたアデノウイルスベクターを用いた発現制御法の開発

1999 - 2004 がんの診断と治療

1999 - 2000 Development of new method for construction of adenovirus vector using gene exchange reaction

1997 - 2000 The analyses on functions and neural toxicity of Amyloid protein precursor, using adenoviral vector.

1997 - 2000 Development of Analysis Method of Immune Surveillance System in Various Animals by using Adenovirus Vector.

1999 - 1999 がん遺伝子治療ベクターの基礎研究

1997 - 1998 Development of double infection method aiming at gene therapy of hepatocarcinoma.

1997 - 1997 SDF1発現アデノウイルスによるエイズ遺伝子治療法開発と、SDF1の諸作用の検討.

1997 - 1997 がん遺伝子治療の基礎的研究

1996 - 1997 Development of a gene therapy vector bearing a swiching mechanism of gene expression

1996 - 1996 Development of an adenovirus vector with long-term expression by supression of the CTL induction

1994 - 1996 Study of mechanism of action of cytokines and signaling molecules using adenoviral transient expression vectors

1994 - 1996 Information Exchange on Cancer Research with North American

1995 - 1995 がんの遺伝子治療をめざしたアデノウイルスベクターの開発

1994 - 1995 Gene therapy of urea cycle deficirncy

1993 - 1995 Development of cytotoxicity test for outbred animals using recombinant viruses.

1994 - 1994 アデノウイルスベクターを用いた目的蛋白の新しい大量産生法の開発

1994 - 1994 難治性疾患に対する遺伝子治療の臨床への展開

1994 - 1994 がんの遺伝子治療をめざしたアデノウイルスベクターの開発

1993 - 1994 Biotechnological studies on the mechanisms regulating embryogenesis

1993 - 1993 遺伝子治療をめざしたアデノウイルス発現ベクターの開発

1993 - 1993 C型肝炎ウイルスの遺伝子発現機構

1992 - 1992 C型肝炎ウイルスの遺伝子発現機構

1991 - 1991 高発現汎用型アデノウイルスベクタ-の開発

1990 - 1990 C型肝炎ウイルスの遺伝子発現と肝炎・肝癌発症

1988 - 1990 Search for Non-A, Non-B Hepatitis Agent

1989 - 1989 極微量DNAをクロ-ン化できるシャロミドベクタ-の開発と応用

1987 - 1987 マルチインサートコスミドを用いたB型肝炎ウイルスDNAのトランスホーム能の解析

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Papers (81)：

Tomomi Nakahara, Hirotaka Tabata, Yuya Kato, Ryoko Fuse, Mariko Nakamura, Megumi Yamaji, Nobutaka Hattori, Tohru Kiyono, Izumu Saito, Tomoko Nakanishi. Construction and Stability of All-in-One Adenovirus Vectors Simultaneously Expressing Four and Eight Multiplex Guide RNAs and Cas9 Nickase. International journal of molecular sciences. 2024. 25. 16
Kato Y, Tabata H, Sato K, Nakamura M, Saito I, Nakanishi T. Adenovirus vectors expressing eight multiplex guide RNAs of CRISPR/Cas9 efficiently disrupted diverse hepatitis B virus gene derived from heterogeneous patient. Int J Mol Sci. 2021. 22. 10570
Tomoko Nakanishi, Aya Maekawa, Mariko Suzuki, Hirotaka Tabata, Kumiko Sato, Mai Mori, Izumu Saito. Construction of adenovirus vectors simultaneously expressing four multiplex, double-nicking guide RNAs of CRISPR/Cas9 and in vivo genome editing. Scientific reports. 2021. 11. 1. 3961-3961
Yamazaki M, Matsda N, Matoba K, Kondo S, Kanegae Y, Saito I, Nomoto A. Acetophenone 4-nitrophenylhydrazone inhibits hepatitis B virus replication by modulating capsid assembly. Virus Res. 2021. 306. 198565
Tomoko Nakanishi, Aya Maekawa, Hirotaka Tabata, Takashi Yoshioka, Zheng Pei, Kumiko Sato, Mai Mori, Masaya Kato, Izumu Saito. Highly multiplex guide RNA expression units of CRISPR/Cas9 were completely stable using cosmid amplification in a novel polygonal structure. The journal of gene medicine. 2019. 21. 11. e3115

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MISC (68)：

長尾知佳, 安田佳織, 岡田只士, 西川美宇, 生城真一, 中西友子, 斎藤泉, 榊利之. ビタミンD1α位水酸化酵素発現アデノウイルスベクターを用いたI型くる病モデルラットの治療. ビタミン. 2022. 96. 4. 201-201
Tomoko Nakanishi, Tomomi Nakahara, Tohru Kiyono, Tsuneo Ikenoue, Yoichi Furukawa, Izumu Saito. Adenovirus vectors expressing highly multiplex double-nicking guide RNAs in vivo: high efficiency and low off-target. CANCER SCIENCE. 2018. 109. 251-251
蔭山俊, 和栗聡, 鐘ヶ江裕美, 曽友深, 一村義信, 斎藤泉, 福田光則, 小松雅明. Alfyによるメンブレントラフィック制御. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [2P0069]-[2P0069]
S. Kondo, A. Maekawa, M. Suzuki, Y. Kanegae, I. Saito. First-generation adenovirus vector expresses viral-associated (VA) RNAs that disturb cellular gene expressions. HUMAN GENE THERAPY. 2013. 24. 12. A79-A79
Saki Kondo, Yumi Kanegae, Nic Jones, Izumu Saito. A role of microRNAs for sensitization to cisplatin in ovarian cancer cell lines. HUMAN GENE THERAPY. 2012. 23. 10. A96-A96

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Patents (2)：

New virus vectors and their methods of production and use
Production methods of vectors containing DNA cassettes connecting multiplex expressing units

Education (2)：

1978 - 1982 The University of Tokyo, D.Med.Sci. (Ph.D) Department of Tumor Viruses, Institute of Medical Science Graduate Course of Medicine
1972 - 1978 The University of Tokyo (license of medical doctor obtained) Medical School of Medicine

Professional career (1)：

D.Med.Sci.(Ph.D.) (The University of Tokyo)

Work history (8)：

2021 - 現在 Juntendo University Graduate School of Medicine
2020 - 2021 National Center for Child Health and Development
2017 - 2020 Institute of Microbial Chemistry Department of Virology Team Leader
2000 - 2017 The University of Tokyo Laboratory of Molecular Genetics, Institute of Medical Science Professor
1991 - 2000 The University of Tokyo Laboratory of Molecular Genetics, Institute of Medical Science, Associate Professor, Facility Head

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Committee career (2)：

2021 - 2022 Ministry of Education and Science Chair, Recombinant DNA Advisory Committee
- 2014 The 20th Japan Society Gene Therapy Annual Meeting President

Association Membership(s) (5)：

Japan Society of Gene and Cell Therapy , Japanese Society for Genome Editing , Japan Society of Molecular Biology , Japanese society for Virology , The Japanese Cancer Association

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