Suzuki Eriko

Affiliation and department：
Job title： Assistant Professor
Other affiliations (3)：

Tokyo University of Agriculture and Technology Faculty of Agriculture, Department of Applied Biological Science
Tokyo University of Agriculture and Technology Graduate School of Agriculture
Tokyo University of Agriculture and Technology United Graduate School of Agricultural Science

Research field (1)： Cell biology

Research keywords (1)：微生物が生み出す、血栓溶解活性を有する化合物、慢性炎症やメタボリックシンドロームなどを改善する化合物などについて研究しています。私達の発見した化合物の中には、既に動物モデルで、脂肪肝や脳梗塞への優れた治療効果が見出されているものもあり、現在医薬開発を進めています。また、最近では、癌と低酸素培養真菌の共培養上清中に、癌幹細胞の形質を有し、より腫瘍形成能の高い癌幹細胞亜集団(holoclone)の増殖抑制活性を見出し、活性物質の同定と、作用機序解析も行っています。

Research theme for competitive and other funds (3)：

2017 - 2017 新規創薬標的としてのEPHX2 phosphatase:生理的基質と阻害剤の探索
2014 - 2017 抗炎症化合物SMTP-7の脂肪肝改善作用におけるsEHとERストレスの寄与の検討
2010 - 2013 腎癌細胞における有機アニオントランスポーターOAT1の薬剤感受性への寄与

Papers (28)：

Xiaowen Shi, Yasuyuki Ohta, Jingwei Shang, Ryuta Morihara, Yumiko Nakano, Yusuke Fukui, Xia Liu, Tian Feng, Yong Huang, Kota Sato, et al. Neuroprotective effects of SMTP-44D in mice stroke model in relation to neurovascular unit and trophic coupling. Journal of neuroscience research. 2018. 96. 12. 1887-1899
Suzuki E, Nishimura N, Yoshikawa T, Kunikiyo Y, Hasegawa K, Hasumi K. Efficacy of SMTP-7, a small-molecule anti-inflammatory thrombolytic, in embolic stroke in monkey. Pharmacology Research & Perspectives. 2018. in press
Yong Huang, Yasuyuki Ohta, Jingwei Shang, Ryuta Morihara, Yumiko Nakano, Yusuke Fukui, Xia Liu, Xiaowen Shi, Tian Feng, Toru Yamashita, et al. Antineuroinflammatory Effect of SMTP-7 in Ischemic Mice. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2018. 27. 11. 3084-3094
Huang Y, Ohta Y, Shang J, Li X, Liu X, Shi X, Feng T, Yamashita T, Sato K, Takemoto M, et al. Reduction of Ischemia Reperfusion-Related Brain Hemorrhage by Stachybotrys Microspora Triprenyl Phenol-7 in Mice With Antioxidant Effects. J Stroke Cerebrovasc Dis. 2018. 11. 30460-30469
Nakasone Y, Oozono J, Suzuki E, Hasumi K, Kondo S. Effect of intake of molecular hydrogen-infused water on the status of obesity in adult subjects: a double-blind, placebo-controlled, parallel-group study. Jpn Phrmacol Ther. 2017. 45. 11. 1821-1830

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MISC (18)：

Eriko Suzuki, Tracy R. Daniels, Gustavo Helguera, Manuel L. Penichet, Kazuo Umezawa, Benjamin Bonavida. Inhibition of NF-kappa B and Akt pathways by an antibody-avidin fusion protein sensitizes malignant B-cells to cisplatin-induced apoptosis. INTERNATIONAL JOURNAL OF ONCOLOGY. 2010. 36. 5. 1299-1307
Kiichiro Kodaira, Eiji Kikuchi, Michio Kosugi, Yutaka Horiguchi, Kazuhiro Matsumoto, Kunimitsu Kanai, Eriko Suzuki, Akira Miyajima, Ken Nakagawa, Masaaki Tachibana, et al. Potent Cytotoxic Effect of a Novel Nuclear Factor-kappa B Inhibitor Dehydroxymethylepoxyquinomicin on Human Bladder Cancer Cells Producing Various Cytokines. UROLOGY. 2010. 75. 4. 805-812
Kiichiro Kodaira, Eiji Kikuchi, Michio Kosugi, Yutaka Horiguchi, Kazuhiro Matsumoto, Kunimitsu Kanai, Eriko Suzuki, Akira Miyajima, Ken Nakagawa, Masaaki Tachibana, et al. Potent Cytotoxic Effect of a Novel Nuclear Factor-kappa B Inhibitor Dehydroxymethylepoxyquinomicin on Human Bladder Cancer Cells Producing Various Cytokines. UROLOGY. 2010. 75. 4. 805-812
Kunimitsu Kanai, Eiji Kikuchi, Shuji Mikami, Eriko Suzuki, Yasumitsu Uchida, Kiichiro Kodaira, Akira Miyajima, Takashi Ohigashi, Jun Nakashima, Mototsugu Oya. Vitamin E succinate induced apoptosis and enhanced chemosensitivity to paclitaxel in human bladder cancer cells in vitro and in vivo. CANCER SCIENCE. 2010. 101. 1. 216-223
Kunimitsu Kanai, Eiji Kikuchi, Shuji Mikami, Eriko Suzuki, Yasumitsu Uchida, Kiichiro Kodaira, Akira Miyajima, Takashi Ohigashi, Jun Nakashima, Mototsugu Oya. Vitamin E succinate induced apoptosis and enhanced chemosensitivity to paclitaxel in human bladder cancer cells in vitro and in vivo. CANCER SCIENCE. 2010. 101. 1. 216-223

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Patents (1)：

クロマン誘導体

Books (5)：

新規脳梗塞治療薬SMTP-7の抗炎症作用機序の解析
一般社団法人日本血栓止血学会 2015
臨床遺伝学'09 -がんの遺伝子学-
最新医学社 2009
がんの分子標的治療
南山堂 2008
医学のあゆみ
医歯薬出版 2008
バイオ医薬の開発技術とシーズ
シーエムシー出版 2008 ISBN:9784781300771

Lectures and oral presentations (53)：

The biological role of soluble epoxide hydrolase N-terminal phosphatase and a novel approach for the identification of its physiological substrate
(第90回日本生化学会 2017)
Investigation of the responsible factors governing the cancer microbiome and crosstalk among cancer cells
(第90回日本生化学会 2017)
Nterm-phosphatase of soluble epoxide hydrolase (sEH) in the regulation of inflammation
(International exchange meeting at Lingnan Normal University 2017)
HABP2 (PHBP/FSAP) is the major plasma protease that promote extracellular histone degradation
(60th International Society of Thrombosis and Haemostasis 2017)
Nterm-phosphatase of soluble epoxide hydrolase (sEH) in the regulation of vascular endothelial inflammation
(60th International Society of Thrombosis and Haemostasis 2017)

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Education (4)：

2008 - 2010 Keio University Graduate School Graduate School of Medicine
2005 - 2008 Keio University Graduate School of Science and Technology Faculty of Science and Technology
2003 - 2005 Keio University Graduate School of Science and Technology Graduate School of Science and Technology Faculty of Science and Technology
1999 - 2003 Keio University Science and Technology Department of Applied Chemistry

Professional career (1)：

博士(理学) (慶應義塾大学)

Work history (3)：

2013/04/01 - - 東京農工大学大学院農学研究院応用生命化学部門助教
2010/04/01 - 2013/03 - 東京農工大学女性未来育成機構助教
2008/04/01 - 2010/03/31 - 慶應義塾大学医学部泌尿器科特別研究助教

Awards (6)：

2016/10/21 - The 1st Joint Meeting of ISFP and PA Workshop Travel Grants for Young Investigators, The 1st Joint Meeting of ISFP and PA Workshop
2015/05/21 - 日本血栓止血学会学術奨励賞
2013/07 - International Society on Thrombosis and Haemostasis Young Investigator Awards, 24th International Society on Thrombosis and Haemostasis
2011/07 - International Society on Thrombosis and Haemostasis Young Investigator Awards, 23th International Society on Thrombosis and Haemostasis
2007/11 - 慶應義塾大学国際学会論文発表奨励賞

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Association Membership(s) (2)：

Japan Society for Bioscience, Biotechnology and Agrochemistry , Japanese society on Thrombosis and Haemostasis

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