Murai Masatoshi

ムライマサトシ | Murai Masatoshi

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www.biofunc-chem.kais.kyoto-u.ac.jp/

Research field (1)： Bioorganic chemistry

Research keywords (8)： Chemical Biology , Respiratory complex I , Ubiquinone , Photoaffinity labeling , Organic Synthesis , Respiratory chain , Bioorganic chemistry , Biological organic chemistry

Research theme for competitive and other funds (15)：

2022 - 2025 Screening of the proteins involved in uptake of ubiquinone in Saccharomyces cerevisiae using a synthetic ubiquinone probe I
2017 - 2021 Novel pathway of coenzyme Q biosynthesis
2018 - 2021 Inhibition mechanism of epoxycyclohexenediones on the mitochondrial ADP/ATP carrier
2018 - 2019 Generation of “Light-driven” respiratory complex I through chemical modification
2016 - 2018 Conversion of mitochondrial respiratory complex I to a light-driven proton pump by chemical modification

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Papers (80)：

Ryohei Otani, Takahiro Masuya, Hideto Miyoshi, Masatoshi Murai. Mitochondrial respiratory complex I can be inhibited via bypassing the ubiquinone-accessing tunnel. FEBS Letters. 2024. 598. 1989-1995
Mirai Mizutani, Seina Kuroda, Masahide Oku, Wataru Aoki, Takahiro Masuya, Hideto Miyoshi, Masatoshi Murai. Identification of proteins involved in intracellular ubiquinone trafficking in Saccharomyces cerevisiae using artificial ubiquinone probe. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 2024. 149147-149147
Ryo Ikunishi, Ryohei Otani, Takahiro Masuya, Kyoko Shinzawa-Itoh, Tomoo Shiba, Masatoshi Murai, Hideto Miyoshi. Respiratory complex I in mitochondrial membrane catalyzes oversized ubiquinones. Journal of Biological Chemistry. 2023. 105001-105001
Atsuhito Tsuji, Takahiro Masuya, Norihito Arichi, Shinsuke Inuki, Masatoshi Murai, Hideto Miyoshi, Hiroaki Ohno. Discovery of Bis-sulfonamides as Novel Inhibitors of Mitochondrial NADH-Quinone Oxidoreductase (Complex I). ACS Medicinal Chemistry Letters. 2023. 14. 2. 211-216
Jun-ichi Kishikawa, Moe Ishikawa, Takahiro Masuya, Masatoshi Murai, Yuki Kitazumi, Nicole L. Butler, Takayuki Kato, Blanca Barquera, Hideto Miyoshi. Cryo-EM structures of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae. Nature Communications. 2022. 13. 1. 4082

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MISC (73)：

奥田健司, 村井正俊, 油屋駿介, 青木航, 三芳秀人. ミトコンドリア複合体-Iによる合成ユビキノンQTの還元はプロトン輸送と共役しない. 日本農芸化学会大会講演要旨集(Web). 2016. 2016
稲岡宏幸, 村井正俊, 桝谷貴洋, 油屋駿介, 青木航, 三芳秀人. トシル化学によるミトコンドリア複合体-Iのユビキノン結合部位の特異的メチル化. 日本農芸化学会大会講演要旨集(Web). 2016. 2016
MURAI MASATOSHI, MURAKAMI SONOMI, ITO TAKESHI, MIYOSHI HIDETO. ミトコンドリア複合体-I阻害剤としてのアミロライド類の作用機構研究. 日本農薬学会大会講演要旨集. 2015. 40th. 165
MASUYA TAKAHIRO, MURAI MASATOSHI, MORISAKA HIRONOBU, MIYOSHI HIDETO. ミトコンドリア複合体-Iのピンポイント化学修飾. 日本農薬学会大会講演要旨集. 2015. 40th. 164
OKUDA AYAKA, MURAI MASATOSHI, MIYOSHI HIDETO. 出芽酵母ミトコンドリアVDACにおけるユビキノン結合部位の同定. 日本農芸化学会大会講演要旨集(Web). 2015. 2015. 2D12A07 (WEB ONLY)

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Lectures and oral presentations (150)：

Elcidating the action mechanism of inhibitors against Na+-pumping NADH-quinone oxidoreductase from Vibrio cholera
(Japan Society of Bioscience, Biotechnology, and Agrochemistry, 2024 annual meeting 2024)
Comprehensive screening of the proteins involved in the trafficking of coenzyme Q in Saccharomyces cerevisiae using a synthetic ubiquinone probe
(Japan Society of Bioscience, Biotechnology, and Agrochemistry, 2024 annual meeting 2024)
Defining the action mechanism of diariyisooxazole-3-caboxamides, small molecule inhibitors targeting the mitochondrial permeability transition
(Japan Society of Bioscience, Biotechnology, and Agrochemistry, 2024 annual meeting 2024)
Characterization of the quinone-binding pocket of respiratory complex I using a PC-quinazoline hybrid inhibitor
(Japan Society of Bioscience, Biotechnology, and Agrochemistry, 2024 annual meeting 2024)
Characterization of the conformational change of Na+-pumping NADH-quinone oxidoreductase from Vibrio cholerae through specific chemical modification
(Japan Society of Bioscience, Biotechnology, and Agrochemistry, 2024 annual meeting 2024)

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Education (2)：

2004 - 2009 Kyoto University Graduate School of Agriculture Division of Applied Life Sciences
2000 - 2004 Kyoto University Faculty of Agriculture

Professional career (1)：

Ph. D in Agriculture (Kyoto University)

Work history (3)：

2018/08 - 現在 Kyoto University Graduate School of Agriculture Associate Professor
2009/04 - 2018/07 Kyoto University Graduate School of Agriculture Assistant Professor
2007/04 - 2009/03 Japan Society for the Promotion of Science JSPS research fellow (DC2)

Committee career (11)：

2023/12 - 現在 Japan Bioenergetics Group Coordinator
2023/04 - 現在 Japan Society for Bioscience, Biotechnology, and Agrochemistry Editorial Board Member (Japanese Edition)
2021/04 - 現在日本農芸化学会関西支部参与
2021/04 - 現在 Pesticide Science Society of Japan Committee Member
2018/04 - 現在日本農薬学会学術小集会:農薬バイオサイエンス委員会・委員

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Awards (1)：

2019/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA) JSBBA Award for Young Scientists Exploring the structure and function of mitochondrial respiratory complex I through chemical biology approaches

Association Membership(s) (3)：

Japan Bioenergetics Group , Pesticide Science Society of Japan , Japan Society for Bioscience, Biotechnology, and Agrochemistry

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