Murata Shigeo

ムラタシゲオ | Murata Shigeo

Affiliation and department：
Homepage URL (1)： http://www.f.u-tokyo.ac.jp/~tanpaku/

Research field (4)： Medical biochemistry , Pharmacology , Pharmaceuticals - health and biochemistry , Functional biochemistry

Research keywords (3)：プロテアソーム , ユビキチン , タンパク質分解

Research theme for competitive and other funds (28)：

2018 - 2022 Regulatory mechanism of intracellular dynamics of conformationally aberrant proteins and its pathophysiological significance

2017 - 2019 Functional analysis of a novel regulatory axis of a proteasome in cancer development

2014 - 2019 The Proteasome: Mechanistic Actions and In-depth Physiopathological Analyses

2013 - 2018 Dynamics and function of the proteasome

2014 - 2016 ミスフォールドタンパク質の核外排出分子機構の解析

2014 - 2016 Screening for proteasome-activating compounds that could cure neurodegenerative diseases

2011 - 2013 Significance of proteasome dysfunction in the development of obesity-mediated hepatic insulin resistance

2009 - 2013 In-depth Analysis of Proteasome-Mediated Regulatory Proteolysis

2011 - 2012 Roles of degradation products generated by the proteasome

2010 - 2012 胚性プロテアソームによるタンパク質品質管理機構とその機能の解明

2010 - 2011 Studies on the assembly of the proteasome

2008 - 2009 正の選択を制御するペプチドの解析

2007 - 2009 Regulation of acquired immunity by thymus-specific proteasomes

2005 - 2009 Analyses of Molecular Assembly and Diversity of Proteasomes

2007 - 2007 プロテアソームの形成と発現制御機構の解析

2005 - 2006 プロテアソームの分子集合に関与する因子の同定と解析

2005 - 2005 ニューロンにおける品質管理の遺伝学的解析

2001 - 2005 Studies on proteolysis mediated by the proteasomes and ubiquitin

2003 - 2004 タンパク質品質管理を担うシャペロン依存型ユビキチンリガーゼCHIPの遺伝学的解析

2002 - 2003 タンパク質品質管理を担うシャペロン依存型ユビキチンリガーゼの遺伝学的解析

2002 - 2003 p57^<kip2>のユビキチンリガーゼ(E3)の同定

2002 - 2002 タンパク質品質管理を担うシャペロン依存型ユビキチンリガーゼCHIPの遺伝学的解析

ユビキチン・プロテアソームシステムによるタンパク質分解

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Papers (148)：

Yuki Mori, Yoshino Akizuki, Rikuto Honda, Miyu Takao, Ayaka Tsuchimoto, Sota Hashimoto, Hiroaki Iio, Masakazu Kato, Ai Kaiho-Soma, Yasushi Saeki, et al. Intrinsic signaling pathways modulate targeted protein degradation. Nature communications. 2024. 15. 1. 5379-5379
Jun Hamazaki, Shigeo Murata. Relationships between protein degradation, cellular senescence, and organismal aging. Journal of biochemistry. 2024. 175. 5. 473-480
Nodoka Nago, Shigeo Murata, Keiji Tanaka, Nobuyuki Tanahashi. Changes in brain proteasome dynamics associated with aging. Genes to Cells. 2024
Tomohiro Iriki, Hiroaki Iio, Shu Yasuda, Shun Masuta, Masakazu Kato, Hidetaka Kosako, Shoshiro Hirayama, Akinori Endo, Fumiaki Ohtake, Mako Kamiya, et al. Senescent cells form nuclear foci that contain the 26S proteasome. Cell reports. 2023. 112880-112880
Xiangyu Zhou, Kengo Watanabe, Kazuhiro Morishita, Jun Hamazaki, Shigeo Murata, Isao Naguro, Hidenori Ichijo. Proteasomal regulation of ASK family kinases dictates cell fate under hyperosmotic stress. 2023

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MISC (43)：

松平竜之, 向井康治朗, 野口大心, 長谷川純矢, 八田知久, 家村俊一郎, 夏目徹, 宮村憲央, 仁科博史, 中山淳, et al. エンドソーム膜のホスファチジルセリンを介したYAPの活性化機構の解明. 生命科学系学会合同年次大会. 2017. 2017年度. [1P-0321]
Pathophysiological roles of proteasome-mediated protein degradation. 2016. 256. 8. 908-912
Protein degradation via ubiquitin proteasome system and disease. 2015. 254. 5. 327-333
濱崎純, 村田茂穂. Oxidative stress and the regulation of proteasome function. 医学のあゆみ. 2013. 247. 9. 819-824
申承旭, 村田茂穂, 松本和也. 初期胚におけるプロテアソーム分解系の生理学的意義. Journal of mammalian ova research = 日本哺乳動物卵子学会誌. 2013. 30. 3. 79-85

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Professional career (1)：

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