Research field (4)：
Fetal medicine/Pediatrics
, Hematology and oncology
, Cell biology
, Molecular biology
Research keywords (3)：
Regulatory Science
, 遺伝子治療
, Gene Therapy
Research theme for competitive and other funds (27)：
1996 - 2023 Development of New Vectors for Gene Therapy
1994 - 2023 Proliferation and Differentiation of Hemutopoietic Stem cells
2018 - 2021 Establishment of virus-free cell substrates for protein drug production
2010 - 2015 Immunological analysis of neonatal diseases by profile assays of cytokines, cytokine-related genes and transcription factors
2011 - 2013 Genome instability caused by EVI1 oncogene activation
1996 - 2013 遺伝子治療ベクターの開発
2008 - 2010 Extrahepatic tissue-targeted gene therapy for phenylketonuria
2006 - 2007 新規クロマチンインシュレータを搭載した遺伝子治療ベクターの開発
2005 - 2006 新生児期遺伝子治療におけるアデノ随伴ウイルスベクターの体内動態と治療効果
2004 - 2006 Gene therapy for chronic granulomatous disease in combination with selective cell amplification and utilizing hematopoietic microenvironment
2004 - 2005 DEDIFFERENTIATION OF NON-HEMATOPOIETIC TISSUE BY GENETIC MANIPULATION AND ITS ACQUISITION OF PLASTICITY AND HEMATOPOIETIC TRANSDIFFERENTIATION
2002 - 2003 Gene therapy for chronic granulomatous disease combined with in vivo expansion of transduced hematopoietic cells.
1994 - 2003 造血幹細胞の増殖および分化
2002 - 2002 キメラ受容体遺伝子導入による白血病細胞療法の効果増強
2000 - 2001 Development of the gene therapy technologies using adeno-associated virus (AAV)
1999 - 2001 Gene transfer into hematopoietic stem cells and gene therapy for chronic granulomatous disease
Teruhide Yamaguchi, Eriko Uchida, Takashi Okada, Keiya Ozawa, Masafumi Onodera, Akihiro Kume, Takashi Shimada, Satoru Takahashi, Kenzaburo Tani, Yasutomo Nasu, et al. Aspects of Gene Therapy Products Using Current Genome-Editing Technology in Japan. Human gene therapy. 2020. 31. 19-20. 1043-1053
Miyata S, Tominaga K, Sakashita E, Urabe M, Onuki Y, Gomi A, Yamaguchi T, Mieno M, Mizukami H, Kume A, et al. Comprehensive Metabolomic Analysis of IDH1R132H Clinical Glioma Samples Reveals Suppression of β-oxidation Due to Carnitine Deficiency. Scientific reports. 2019. 9. 1. 9787
Fumio Kurosaki, Ryosuke Uchibori, Yoshihide Sehara, Yasushi Saga, Masashi Urabe, Hiroaki Mizukami, Koichi Hagiwara, Akihiro Kume. AAV6-Mediated IL-10 Expression in the Lung Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice. Human gene therapy. 2018. 29. 11. 1242-1251
Hiroaki Mizukami, Tsukasa Ohmori, Ryosuke Uchibori, Yasushi Saga, Masashi Urabe, Akihiro Kume, Yoichi Sakata, Keiya Ozawa. Duration of Factor IX Expression in Macaques Following AAV8-Mediated Liver Transduction. MOLECULAR THERAPY. 2016. 24. S87-S87
Masashi Urabe, Ryosuke Uchibori, Akihiro Kume, Hiroaki Mizukami, Keiya Ozawa. The Use of Thymidine Kinase Mutants as a Safeguard Switch for IPS Cells. MOLECULAR THERAPY. 2016. 24. S95-S96
H. Mizukami, T. Ohmori, R. Uchibori, T. Tsukahara, Y. Saga, M. Urabe, A. Kume, Y. Sakata, K. Ozawa. Persistent factor IX expression following AAV8-mediated liver transduction in macaques. HUMAN GENE THERAPY. 2015. 26. 10. A31-A31
Ryosuke Uchibori, Takeshi Teruya, Soranobu Ninomiya, Hiroyuki Ido, Tomonori Tsukahara, Ken Ohmine, Masashi Urabe, Yasushi Saga, Akihiro Kume, Hiroaki Mizukami, et al. Activation Signals from CD19-CAR Permit NFAT-Controlled Inducible Expression of Transgenes in PBMCs. MOLECULAR THERAPY. 2015. 23. S89-S89
N. Sato, Y. Saga, H. Mizukami, R. Uchibori, T. Tsukahara, M. Urabe, A. Kume, M. Suzuki, K. Ozawa. Elimination of cervical cancer in vivo by a short-hairpin RNA targeting human papillomavirus type 16 E6/E7. HUMAN GENE THERAPY. 2014. 25. 11. A81-A81
CD34 Workshop : Cross - linking of CD34 on hematopoietic cells induces homotypic cell adhesion via clustering of CD34 and mobilization of adhesion molecules. (共著)
Lenkocyte Typing VI , Garland Puhilishing Inc . , New York and London 1997
