Ichisaka Satoshi

イチサカサトシ | Ichisaka Satoshi

Affiliation and department：
Job title： Assistant Professor

Research field (3)： Clinical pharmacy , Physiology , Neuroscience - general

Research keywords (16)： prefrontal cortex , maltreatment , 治療法開発 , 攻撃性 , 心の再生 , 精神疾患 , 眼窩前頭皮質 , 生後環境 , シグナル分子 , 臨界期 , 発達 , 可塑性 , critical period , orbitofrontal , development , plasticity

Research theme for competitive and other funds (9)：

2018 - 2022 幼少期ストレス負荷ラットの衝動的攻撃性への前頭前野を標的とした根治療法開発
2016 - 2018 Effect of early life stress on impulsive aggression and neural circuit in the prefrintal cortex
2009 - 2011 Regeneration of mind : Development of a novel treatment of psychiatric disorder caused by nurturing environment such as child abuse
2005 - 2009 Experience-dependent remodeling of visual neural circuits.
2004 - 2006 Non-Hebbian type of plasticity in the developing visual cortex.

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Papers (16)：

Yasuhiro Kazuki, Feng J Gao, Miho Yamakawa, Masumi Hirabayashi, Kanako Kazuki, Naoyo Kajitani, Sachiko Miyagawa-Tomita, Satoshi Abe, Makoto Sanbo, Hiromasa Hara, et al. A transchromosomic rat model with human chromosome 21 shows robust Down syndrome features. American journal of human genetics. 2022. 109. 2. 328-344
Hiroshi Kuniishi, Satoshi Ichisaka, Miki Yamamoto, Natsuko Ikubo, Sae Matsuda, Eri Futora, Riho Harada, Kohei Ishihara, Yoshio Hata. Early deprivation increases high-leaning behavior, a novel anxiety-like behavior, in the open field test in rats. Neuroscience research. 2017. 123. 27-35
Hiroshi Kuniishi, Satoshi Ichisaka, Sae Matsuda, Eri Futora, Riho Harada, Yoshio Hata. Chronic Inactivation of the Orbitofrontal Cortex Increases Anxiety-Like Behavior and Impulsive Aggression, but Decreases Depression-Like Behavior in Rats. Frontiers in behavioral neuroscience. 2016. 10. 250-250
Michiko Hamatake, Noriko Miyazaki, Kaori Sudo, Motoko Matsuda, Tetsushi Sadakata, Asako Furuya, Satoshi Ichisaka, Yoshio Hata, Chiaki Nakagawa, Koh-ichi Nagata, et al. Phase advance of the light-dark cycle perturbs diurnal rhythms of brain-derived neurotrophic factor and neurotrophin-3 protein levels, which reduces synaptophysin-positive presynaptic terminals in the cortex of juvenile rats. The Journal of biological chemistry. 2011. 286. 24. 21478-87
R Katoh-Semba, R Kaneko, S Kitajima, M Tsuzuki, S Ichisaka, Y Hata, H Yamada, N Miyazaki, Y Takahashi, K Kato. Activation of p38 mitogen-activated protein kinase is required for in vivo brain-derived neurotrophic factor production in the rat hippocampus. Neuroscience. 2009. 163. 1. 352-61

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MISC (48)：

一坂吏志. 精神科領域の用語解説眼窩前頭皮質(別名:前頭眼窩野). 分子精神医学. 2018. 18. 2. 96-99
山本未希, 一坂吏志, 仙波りつ子, 畠義郎. BDNF量はPKAあるいは神経活動の阻害によりp-CREBではなくMeCP2の変化を伴って変化する(Inhibition of PKA or neuronal activity alters BDNF level with a change in the level of MeCP2 reversely, but not p-CREB, in the rat visual cortex). 神経化学. 2011. 50. 2-3. 193-193
一坂吏志, 山本未希, 井久保樹子, 國石洋, 畠義郎. 新生児期における母子分離経験はオープンフィールド試験における寄りかかり行動を増加させる(Neonatal maternal separation increases leaning-against-wall behavior in open field test). 神経化学. 2011. 50. 2-3. 204-204
R. Katoh-Semba, R. Kaneko, S. Kitajima, M. Tsuzuki, S. Ichisaka, Y. Hata, H. Yamada, N. Miyazaki, Y. Takahashi, K. Kato. ACTIVATION OF p38 MITOGEN-ACTIVATED PROTEIN KINASE IS REQUIRED FOR IN VIVO BRAIN-DERIVED NEUROTROPHIC FACTOR PRODUCTION IN THE RAT HIPPOCAMPUS. NEUROSCIENCE. 2009. 163. 1. 352-361
Satoshi Ichisaka, Manami Miyahara, Ayano Yamamoto, Kazuhiro Kojima, Yoshio Hata. Developmental changes of signaling molecules that regulate neurite outgrowth and myelination in the rat orbitofrontal and visual cortex. NEUROSCIENCE RESEARCH. 2009. 65. S160-S160

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Books (4)：

眼窩前頭皮質(別名:前頭眼窩野) 一坂吏志
先端医学社 2018
脳の神経回路形成の臨界期一坂吏志、畠義郎
生体の科学 2004
眼優位可塑性における神経栄養因子の役割一坂吏志、畠義郎
脳の科学 2002
視覚系の可塑性一坂吏志、津本忠治
CLINICAL NEUROSCIENCE 2000

Lectures and oral presentations (33)：

ラット眼窩前頭皮質の情動行動に対する寄与
(第36回躁うつ病の薬理・生化学的研究懇話会(躁うつ病懇話会) 2017)
Effects of early-life on behaviors, corticosterone level and brain structure, and assessment of treatment for the effects in rats
(2017)
A novel rat model of psychiatric disorders caused by childhood stress and the contribution of the orbitofrontal cortex to its behavioral abnormalities
(2016年9月13日-9月15日(口頭発表9月13日) 2016)
Involvement of orbitofrontal cortex in anxiety- and depression-like behaviors and impulsive aggression in rats
(2016年9月8日-9月10日(ポスター発表9月9 日) 2016)
Attempt to establish a model rat of psychiatric disorders cased by child abuse, and treatment effects of environmental enrichment
(2016)

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Education (1)：

- 2001 Osaka University

Professional career (1)：

博士(医学) (大阪大学)

Association Membership(s) (2)：

日本神経化学会 , 日本神経科学会

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