Hosomichi Jun

ホソミチジユン | Hosomichi Jun

Affiliation and department：
Job title： Junior Associate Professor
Homepage URL (2)： http://www.tmd.ac.jp/dent/ort1/ort1-J.htm;https://researchmap.jp/read0076004/;https://www.researchgate.net/profile/Jun_Hosomichi , https://www.researchgate.net/profile/Jun_Hosomichi

Research field (1)： Developmental dentistry

Research keywords (7)：医科疾患および口腔疾患のトランスレーショナル研究 , 光遺伝学ツールによる骨軟骨再生 , 核酸医薬による口腔疾患の新規治療 , biological responses of bone and periodontal cells to mechanical and hormonal stimuli , osteoarthritis , bone and cartilage regeneration , Pediatric sleep apnea

Research theme for competitive and other funds (44)：

2016 - 現在 NFκBデコイ核酸の超音波マイクロバブル導入による変形性顎関節症の新規治療の開発(文部科学省・日本学術振興会基盤研究C(一般))
2016 - 現在セロトニン受容体障害を介した小児睡眠時無呼吸症候群における上気道閉塞機構の解明(文部科学省・日本学術振興会基盤研究C(一般))
2023 - 2027 妊娠期閉塞性睡眠時無呼吸症:世代を超えた成長発育の破綻・変容と包摂医療への展開
2023 - 2026 乳幼児睡眠時無呼吸症における軟骨代謝障害の疾患感受性遺伝子の同定
2022 - 2025 Basic research on sleep apnea syndrome and infertility and sudden infant death syndrome

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Papers (49)：

Takuma Suzuki, Jun Hosomichi, HideyukiI Maeda, Yuji Ishida, Risa Usumi-Fujita, Manaka Moro, Korkuan Jariyatheerawong, Takashi Ono. Gestational intermittent hypoxia reduces mandibular growth with decreased Sox9 expression and increased Hif1a expression in male offspring rats. Frontiers in Physiology. 2024. 15
Seiko Ishihara, Risa Usumi-Fujita, Yuki Kasahara, Shuji Oishi, Kana Shibata, Yasuhiro Shimizu, Yuji Ishida, Sawa Kaneko, Makoto Sugiura-Nakazato, Makoto J. Tabata, et al. Periostin splice variants affect craniofacial growth by influencing chondrocyte hypertrophy. Journal of Bone and Mineral Metabolism. 2023. 41. 2. 171-181
Wirongrong Wongkitikamjorn, Eiji Wada, Jun Hosomichi, Hideyuki Maeda, Sirichom Satrawaha, Haixin Hong, Ken-Ichi Yoshida, Takashi Ono, Yukiko K Hayashi. Metabolic dysregulation and decreased capillarization in skeletal muscles of male adolescent offspring rats exposed to gestational intermittent hypoxia. Frontiers in physiology. 2023. 14. 1067683-1067683
Hideyuki Maeda, Jun Hosomichi, Akihiro Hasumi, Ken-Ichi Yoshida. Influence of cardiac function on intermittent hypoxia in rats fed with high-fat diet. Biochemistry and biophysics reports. 2022. 32. 101393-101393
Narubhorn Ongprakobkul, Yuji Ishida, Kasumi Hatano-Sato, Kai Li, Sirima Petdachai, Risa Usumi-Fujita, Jun Hosomichi, Korapin Mahatumarat, Takashi Ono. Effects of local vs systemic administration of CXCR4 inhibitor AMD3100 on orthodontic tooth movement in rats. American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics. 2022. 162. 2. 182-192

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MISC (6)：

鈴木拓望, 細道純, 前田秀将, 石田雄之, 臼見莉沙, 毛呂愛香, 小野卓史. 妊娠期の間欠的低酸素曝露が仔ラットの下顎骨の出生後成長に与える影響について. 日本矯正歯科学会大会プログラム・抄録集. 2022. 81回. 146-146
Hong Haixin, Hosomichi Jun, Maeda Hideyuki, Lekvijittada Kochakorn, Oishi Shuji, Kuma Yoichiro, Yamaguchi Hiroyuki, Ishida Yuji, Usumi Risa, Shimizu Yasuhiro, et al. B2アドレナリン受容体作動薬butoxamineはラットにおいて間欠的低酸素負荷により引き起こされる下顎の成長遅延を救済する(B2-adrenergic antagonist butoxamine rescues the mandibular growth retardation caused by intermittent hypoxia in adolescent rats). 日本矯正歯科学会大会プログラム・抄録集. 2018. 77回. 365-365
Hosomichi Jun, Nakai Yuta, Maeda Hideyuki, Kuma Yo-ichiro, Oishi Shuji, Usumi-Fujita Risa, Shimizu Yasuhiro, Kaneko Sawa, Ishida Yuji, Shibutani Naoki, et al. 間欠的な低酸素はオトガイ舌骨筋において炎症経路を刺激して筋原線維とミトコンドリアの生合成の低下を引き起こす(Intermittent hypoxia triggers inflammatory pathway with down-regulated myofibrillar and mitochondrial biogenesis in the geniohyoid muscle). 日本矯正歯科学会大会プログラム・抄録集. 2015. 74回. 141-141
加藤千帆, 藪下忠親, 藤田紘一, 石田雄之, 細道純, 小野卓史. 選択的に上顎側切歯の抜歯を行った2症例. 日本矯正歯科学会大会プログラム・抄録集. 2014. 73回. 326-326
J Hosomichi, N Yasui, T Koide, K Soma, Morita, I. Involvement of collagen-binding motif in anti-angiogenic activity of pigment epithelium-derived factor. MOLECULAR BIOLOGY OF THE CELL. 2004. 15. 226A-226A

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Books (2)：

歯科矯正学第6版
医歯薬出版 2019 ISBN:9784263458327
矯正歯科のための重要16キーワードベスト320論文 (トムソン・ロイターシリーズ)
クインテッセンス出版 2017 ISBN:9784781205793

Lectures and oral presentations (63)：

上顎臼歯の先天性欠如に留意してWunderer法併用Le Fort I型骨切り術を行った骨格性II級開咬の一例
(第31回日本顎変形症学会総会・学術大会 2021)
ラットにおける交感神経機能亢進関与による高血圧と頭蓋骨および脛骨の差次成長
(第85回口腔病学会学術大会 2020)
Intermittent hypoxia reduces RANKL expression in impaired mandibular growth through the β2-adrenergic receptor in adolescent rats.
(The 9th International Orthodontic Congress 2020)
Intermittent hypoxia inhibits mandibular cartilage growth by reducing TGF-β and SOX9 expression levels in infant rats
(The 9th International Orthodontic Congress 2020)
Effects of intermittent hypoxia on learning and memory functions in infant rats
(The 9th International Orthodontic Congress 2020)

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Education (2)：

2001 - 2005 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Orthodontic Sceinece
1995 - 2001 Tokyo Medical and Dental University Faculty of Dentistry School of Dentistry

Professional career (1)：

Ph.D (Tokyo Medical and Dental University)

Work history (7)：

2018/04/01 - 現在 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Oral Health Sciences Orthodontic Science Junior Associate Professor
2015/01/08 - 現在 Tokyo Medical University Department of Forensic Medicine, Graduate School of Medicine Visiting Scholar
2013/04/01 - 2018/03/31 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Oral Health Sciences Orthodontic Science Junior Associate Professor
2006/04/01 - 2013/03/31 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Oral Health Sciences Orthodontic Science Assistant Professor
2010/04/05 - 2012/03/30 University of Michigan, Ann Arbor, USA Department of Orthodontics and Pediatric Dentistry, School of Dentistry Visiting Scholar

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Committee career (2)：

2012 - 現在 Japanese Orthodontic Society Board member
2012 - 現在日本矯正歯科学会代議員

Awards (17)：

2019/11 - Japanese Orthodontic Society The 78th Annual Meeting of Japanese Orthodontic Society, Excellent Poster Award
2018/11 - Japanese Orthodontic Society Sato M, Asano T, Hosomichi J, Ishida Y, Usumi-Fujita R, Shimizu Y, Kaneko S, Nataka T, Ono T. The 77th Annual Meeting of the Japanese Orthodontic Society, Excellent Exhibition Award Elucidation of the molecular mechanism of osteoblast differentiation and its control using optogenetics.
2018/11 - Japanese Orthodotic Society Hong H, Hosomichi J, Maeda H, Lekvijittada K, Oishi S, Kuma Y, Yamaguchi H, Ishida Y, Usumi-Fujita R, Shimizu Y, Kaneko S, Suzuki J, Yoshida K, Ono T. The 77th Annual Meeting of the Japanese Orthodontic Society, Excellent Exhibition Award β2-adrenergic antagonist butoxamine reduces the mandibular growth retardation caused by intermittent hypoxia in adolescent rats.
2018/10 - Japanese Orthodontic Society Hosomichi J. Certificate of Recognition for Orthodontic Waves Reviewer
2018/03 - Asian Pacific Orthodontic Society Hong H, Hosomichi J, Maeda H, Kochakorn L, Oishi S, Kuma Y, Yamaguchi H, Ishida Y, Suzuki J, Yoshida K, Ono T. The 11th Asian Pacific Orthodontic Conference Best Presentation Award (1st Prize) The impact of a ß2-adrenergic antagonist, butoxamine on mandibular growth retardation caused by intermittent hypoxia in growing rats.

2016/10 - Japanese Orthodontic Society The 75th Annual Meeting of the Japanese Orthodontic Society Best Presentation Award

2015/11 - The 74th Annual Meeting of the Japanese Orthodontic Society The 74th Annual Meeting of the Japanese Orthodontic Society Award of Excellence (English Session) Intermittent hypoxia triggers inflammatory pathway with down-regulated myofibrillar and mitochondrial biogenesis in the geniohyoid muscle.

2014/10 - Japanese Orthodontic Society The 73th Annual Meeting of the Japanese Orthodontic Society Excellent Exhibition Award Intermittent hypoxia induces skeletal growth disturbance with osteocleotic changes in growing rats.

2014/10 - Japanese Orthodontic Society The 73th Annual Meeting of the Japanese Orthodontic Society, Excellent Exhibition Award Involvement of G protein-coupled receptor 4 in osteoclastogenesis mediated by osteoblasts.

2013/09 - Japanese Orthodontic Society The 72th Annual Meeting of the Japanese Orthodontic Society, Excellent Exhibition Award Intermittent hypoxia disturbs rat maxillofacial bone growth, leading to discrepancy of maxillofacial morphology.

2013/09 - Japanese Orthodontic Society The 72th Annual Meeting of the Japanese Orthodontic Society, Excellent Exhibition Award Effects of intermittent hypoxia during growing period on 3D morphology of the rat nasal airway.

2012/09 - Japanese Orthodontic Society The 70th Annual Meeting of the Japanese Orthodontic Society Excellent Exhibition Award Differential responses of immortalized TMJ disc cell clones to estrogen, relaxin and progesterone.

2012/09 - Japanese Orthodontic Society The 71th Annual Meeting of the Japanese Orthodontic Society Excellent Exhibition Award Alveolar bone changes induced by the orthodontic movement of the hypofunctional tooth in rats.

2010/11 - Japanese Orthodontic Society The 69th Annual Meeting of the Japanese Orthodontic Society Excellent Exhibition Award

2006/09 - Japanese Orthodontic Society The 1st Joint Meeting of the Japanese Orthodontic Society and the Korean Association of Orthodontists Excellent Exhibition Award Occlusal forces promote periodontal healing of transplanted teeth with enhanced basic fibroblast growth factor synthesis.

2005/10 - Japanese Orthodontic Society The 64th Annual Meeting of the Japanese Orthodontic Society Excellent Exhibition Award

2001/03 - Tokyo Medical and Dental University Nagao-Yu Young Investigator Award

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Association Membership(s) (9)：

The Stomatological Society , 骨免疫学会 , Tokyo Orthodontic Society , Japanese Cleft Palate Association , Japanese Society for Temporomandibular Joint , Japanese Society for Jaw Deformities , Sleep Research Society , Japanese Orthodontic Society , International Association for Dental Research

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