Ashino Takashi

アシノタカシ | Ashino Takashi

Affiliation and department：
Job title： Assistant Professor

Research field (3)： Immunology , Cardiology , Pharmaceuticals - health and biochemistry

Research keywords (7)： Toxicology , Oxidative Stress , Drug metabolism , Inflammation , Arteriosclerosis , Biochemical Toxicology , Drag Metabolism

Research theme for competitive and other funds (11)：

2024 - 2027 Protective role of the oxidative stress response system against liver fibrogenesis in NAFLD/NASH
2021 - 2024 Role of reactive sulfur species in vascular redox regulation and inhibition of arteriosclerosis
2018 - 2020 動脈硬化の進展抑制を指向した活性酸素の産生/消去スイッチング機構の解明
2015 - 2017 酸化ストレス制御因子による血管前駆細胞機能調節を介した血管内膜肥厚抑制機構
2017 - 酸化ストレス誘導性ヘム分解律速酵素による血管内膜肥厚制御機能の解明と動脈硬化進展抑制への応用

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Papers (32)：

Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa. Downregulation of the gene expression of Cyp2c29 and Cyp3a11 by cecal ligation and puncture-induced sepsis is associated with interleukin-6. International immunopharmacology. 2023. 117. 110039-110039
Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa. Interleukin-6 regulates the expression of hepatic canalicular efflux drug transporters after cecal ligation and puncture-induced sepsis: A comparison with lipopolysaccharide treatment. Toxicology letters. 2023. 374. 40-47
Tatsuro Miyoshi, Brian C Keller, Takashi Ashino, Satoshi Numazawa. Noncanonical mechanism of Nrf2 activation by diacylglycerol polyethylene glycol adducts in normal human epidermal keratinocytes. PloS one. 2023. 18. 10. e0291905
Natsumi Hattori-Usami, Asuka Kaizaki-Mitsumoto, Takashi Ashino, Masayuki Yamamoto, Satoshi Numazawa. Toxicity manifestations and sex differences due to MARTA olanzapine. The Journal of toxicological sciences. 2023. 48. 4. 191-202
Takashi Ashino. Regulation of cytochrome P450 expression in oxidative stress-associated pathological conditions. THE SHOWA UNIVERSITY JOURNAL OF MEDICAL SCIENCES. 2022. 81. 5. 387-394

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MISC (62)：

芦野隆, 芦野隆, 千葉莉沙子, 村田百奈美, 柴田佳太, 柴田佳太, 野部浩司, 野部浩司, 岩倉洋一郎, 沼澤聡, et al. Inflammatory cytokine-independent down-regulation of cytochrome P450 in NAFLD/NASH model mice. 日本薬学会年会要旨集(Web). 2024. 144th
芦野隆, 中村祐輝, 大滝博和, 岩倉洋一郎, 沼澤聡. Role of interleukin-6 in the downregulation of hepatic drug transporters by cecal ligation and puncture-induced sepsis. 衛生薬学・環境トキシコロジー講演要旨集. 2023. 2023
芦野隆, 赤池哉太, 千葉莉沙子, 山本雅之, 沼澤聡. Role of Nrf2 antioxidative system on 5-fluorouracil-induced myelosuppression. 日本薬学会年会要旨集(Web). 2023. 143rd
篠内良介, 篠内良介, 佐々木晶子, 柴田佳太, 柴田佳太, 古林創史, 古林創史, 芦野隆, 高木孝士, 辻まゆみ, et al. The effect of mechanical stress on skin structure improvement in the chemotherapy-induced peripheral neuropathy model mice. 日本薬学会年会要旨集(Web). 2023. 143rd
佐々木晶子, 篠内良介, 柴田佳太, 古林創史, 芦野隆, 坂井信裕, 山口真帆, 佐藤ゆり絵, 細沼雅弘, 辻まゆみ, et al. ハンドセラピー施術と冷却法の併用によるCIPNしびれ予防改善効果とメカニズムの解明. 日本癌治療学会学術集会抄録集. 2022. 60回. P91-1

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Education (2)：

Professional career (1)：

Work history (5)：

2020/09 - 現在 Showa University School of Pharmacy Division of Toxicology, Department of Pharmacology, Toxicology, and Therapeutics Associate professor
2016/06 - 2020/08 Showa University School of Pharmacy Division of Toxicology, Department of Pharmacology, Toxicology, and Therapeutics Assistant Professor
2010/04 - 2016/05 Showa University School of Pharmacy Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics Assistant Professor
2008/05 - 2010/03 University of Illinois at Chicago Departments of Medicine (Section of Cardiology) and Pharmacology Postdoctoral Fellow
2001/04 - 2008/04 Showa University Department of Biochemical Toxicology, School of Pharmaceutical Sciences Assistant Professor

Committee career (1)：

Awards (4)：

2023/06 - 昭和大学昭和大学上條奨学賞(研究業績)
2018/11 - American Physiological Society APSselect Copper transporter ATP7A interacts with IQGAP1, a Rac1 binding scaffold protein: Role in PDGF-induced VSMC migration and vascular remodeling
2011/07 - 日本毒性学会日本トキシコロジー学会奨励賞炎症性サイトカインによるシトクロムP450遺伝子発現及び酸化ストレス応答調節機構に関する研究
2011/07 - 日本毒性学会第38回日本トキシコロジー学会学術年会優秀研究発表賞血管平滑筋細胞遊走と血管リモデリングにおける銅トランスポーターATP7Aの新規役割

Association Membership(s) (2)：

THE JAPANESE SOCIETY OF TOXICOLOGY , 日本薬学会

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