Rchr
J-GLOBAL ID:200901072803269601   Update date: Feb. 01, 2024

Ashino Takashi

アシノ タカシ | Ashino Takashi
Affiliation and department:
Job title: Assistant Professor
Research field  (3): Immunology ,  Cardiology ,  Pharmaceuticals - health and biochemistry
Research keywords  (7): Toxicology ,  Oxidative Stress ,  Drug metabolism ,  Inflammation ,  Arteriosclerosis ,  Biochemical Toxicology ,  Drag Metabolism
Research theme for competitive and other funds  (10):
  • 2021 - 2024 Role of reactive sulfur species in vascular redox regulation and inhibition of arteriosclerosis
  • 2018 - 2020 動脈硬化の進展抑制を指向した活性酸素の産生/消去スイッチング機構の解明
  • 2015 - 2017 酸化ストレス制御因子による血管前駆細胞機能調節を介した血管内膜肥厚抑制機構
  • 2017 - 酸化ストレス誘導性ヘム分解律速酵素による血管内膜肥厚制御機能の解明と動脈硬化進展抑制への応用
  • 2015 - 酸化ストレス応答系を標的とした血管リモデリング制御機能の解明と動脈硬化進展抑制への応用
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Papers (32):
  • Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa. Downregulation of the gene expression of Cyp2c29 and Cyp3a11 by cecal ligation and puncture-induced sepsis is associated with interleukin-6. International immunopharmacology. 2023. 117. 110039-110039
  • Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa. Interleukin-6 regulates the expression of hepatic canalicular efflux drug transporters after cecal ligation and puncture-induced sepsis: A comparison with lipopolysaccharide treatment. Toxicology letters. 2023. 374. 40-47
  • Tatsuro Miyoshi, Brian C Keller, Takashi Ashino, Satoshi Numazawa. Noncanonical mechanism of Nrf2 activation by diacylglycerol polyethylene glycol adducts in normal human epidermal keratinocytes. PloS one. 2023. 18. 10. e0291905
  • Natsumi Hattori-Usami, Asuka Kaizaki-Mitsumoto, Takashi Ashino, Masayuki Yamamoto, Satoshi Numazawa. Toxicity manifestations and sex differences due to MARTA olanzapine. The Journal of toxicological sciences. 2023. 48. 4. 191-202
  • Takashi Ashino. Regulation of cytochrome P450 expression in oxidative stress-associated pathological conditions. THE SHOWA UNIVERSITY JOURNAL OF MEDICAL SCIENCES. 2022. 81. 5. 387-394
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MISC (58):
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Education (2):
  • 1999 - 2001 Showa University Guraduate School of Pharmaceutical Sciences
  • 1995 - 1999 Showa University School of Pharmacy Division of Pharmacology
Professional career (1):
  • Ph.D. (Showa University)
Work history (5):
  • 2020/09 - 現在 Showa University School of Pharmacy Division of Toxicology, Department of Pharmacology, Toxicology, and Therapeutics Associate professor
  • 2016/06 - 2020/08 Showa University School of Pharmacy Division of Toxicology, Department of Pharmacology, Toxicology, and Therapeutics Assistant Professor
  • 2010/04 - 2016/05 Showa University School of Pharmacy Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics Assistant Professor
  • 2008/05 - 2010/03 University of Illinois at Chicago Departments of Medicine (Section of Cardiology) and Pharmacology Postdoctoral Fellow
  • 2001/04 - 2008/04 Showa University Department of Biochemical Toxicology, School of Pharmaceutical Sciences Assistant Professor
Committee career (1):
  • - 現在 日本毒性学会 Fund. Toxicol. Sci. 査読委員
Awards (4):
  • 2023/06 - 昭和大学 昭和大学上條奨学賞(研究業績)
  • 2018/11 - American Physiological Society APSselect Copper transporter ATP7A interacts with IQGAP1, a Rac1 binding scaffold protein: Role in PDGF-induced VSMC migration and vascular remodeling
  • 2011/07 - 日本毒性学会 日本トキシコロジー学会奨励賞 炎症性サイトカインによるシトクロムP450遺伝子発現及び酸化ストレス応答調節機構に関する研究
  • 2011/07 - 日本毒性学会 第38回日本トキシコロジー学会学術年会優秀研究発表賞 血管平滑筋細胞遊走と血管リモデリングにおける銅トランスポーターATP7Aの新規役割
Association Membership(s) (2):
THE JAPANESE SOCIETY OF TOXICOLOGY ,  日本薬学会
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