Rchr
J-GLOBAL ID:200901073217393030   Update date: Apr. 03, 2024

kubo yoshihiro

kubo yoshihiro
Affiliation and department:
Research field  (4): Biophysics ,  Clinical pharmacy ,  Physiology ,  Neuroscience - general
Research keywords  (24): Two pore potassium channel ,  patch clamp ,  Two electrode voltage clamp ,  Xenopus laevis oocytes ,  voltage clamp fluorometry ,  stoichiometry ,  一分子イメージング ,  TPC channel ,  包括脳ネットワーク・広報委員会 ,  包括脳ネットワーク ,  統合脳・分子脳科学 ,  単粒子構造解析 ,  発現密度 ,  構造機能連関 ,  FRET ,  動的構造変化 ,  RGS ,  TRPA1チャネル ,  プレスチン ,  KCNQチャネル ,  ATP受容体チャネル ,  内向き整流性K+チャネル ,  GABAB受容体 ,  代謝型グルタミン酸受容体
Research theme for competitive and other funds  (48):
  • 2023 - 2026 チャネルにおけるイオン透過と非典型的膜電位依存性ゲーティングのカップリングの検証
  • 2020 - 2023 イオンチャネルの動的構造変化の蛍光非天然アミノ酸・遷移金属イオン間FRET解析
  • 2017 - 2020 Analysis of dynamic structural rearrangements of functioning ion channels by fluorescent unnatural amino acid
  • 2015 - 2017 Analyses of structural rearrangements of membrane proteins by fluorescent unnatural amino acid scanning
  • 2014 - 2017 Analyses of an orphan metabotropic receptor which plays a role in the long term retention of memory, and a secretory protein encoded by its splice variant
Show all
Papers (132):
  • Chang Liu, I-Shan Chen, Michihiro Tateyama, Yoshihiro Kubo. Structural determinants of the direct inhibition of GIRK channels by Sigma-1 receptor antagonist. The Journal of biological chemistry. 2024. 107219-107219
  • Hisao Tsukamoto, Yoshihiro Kubo. A self-inactivating invertebrate opsin optically drives biased signaling toward Gβγ-dependent ion channel modulation. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 21. e2301269120
  • Takushi Shimomura, Kiichi Hirazawa, Yoshihiro Kubo. Conformational rearrangements in the second voltage sensor domain switch PIP2- and voltage-gating modes in two-pore channels. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 6. e2209569120
  • Niklas Brake, Adamo S Mancino, Yuhao Yan, Takushi Shimomura, Yoshihiro Kubo, Anmar Khadra, Derek Bowie. Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific. The Journal of general physiology. 2022. 154. 7
  • I-Shan Chen, Jodene Eldstrom, David Fedida, Yoshihiro Kubo. A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K+ channel. The Journal of physiology. 2021. 600. 3. 603-622
more...
MISC (69):
  • I-Shan Chen, Chang Liu, Michihiro Tateyama, Izhar Karbat, Motonari Uesugi, Eitan Reuveny, Yoshihiro Kubo. Inhibitory Mechanisms of G-protein-gated Inwardly Rectifying K+ Channel by Antihistamines. BIOPHYSICAL JOURNAL. 2020. 118. 3. 117A-117A
  • Atsushi Suzuki, Jun Ishii, Aya Yoshida, Naoya Yamguchi, Tatsushi Tanaka, Kohei Aoyama, Michihiro Tateyama, I-Shan Chen, Yoshihiro Kubo, Toru Kimura, et al. Homozygous loss-of-function mutation in the SLC26A7 gene coding a novel iodide transporter causes goitrous congenital hypothyroidism. HORMONE RESEARCH IN PAEDIATRICS. 2019. 91. 36-36
  • I-Shan Chen, Michihiro Tateyama, Yuko Fukata, Motonari Uesugi, Yoshihiro Kubo. Effects and Activation Mechanisms of Ivermectin on G-Protein-Gated Inwardly Rectifying Potassium Channels. BIOPHYSICAL JOURNAL. 2018. 114. 3. 301A-301A
  • Osamu Saitoh, Mai Oda, Mako Kurogi, Yoshihiro Kubo. Functional analysis of TRPA1 of zebrafish and pufferfish. GENES & GENETIC SYSTEMS. 2014. 89. 6. 297-297
  • 中條浩一, 久保義弘. チャネル病. 2014
more...
Work history (6):
  • 2003 - 現在 National Institute for Physiological Sciences Department of Molecular & Cellular Physiology, Division of Biophysics & Neurobiology
  • 2000 - 2003 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences
  • 1997 - 2000 東京都神経科学総合研究所 副参事研究員
  • 1993 - 1997 東京都神経科学総合研究所 主任研究員
  • 1991 - 1993 University of California, San Francisco
Show all
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page