Rchr

J-GLOBAL ID：200901073352560265 Update date: Dec. 22, 2025

Nishida Takashi

ニシダタカシ | Nishida Takashi

Affiliation and department：
Job title： Associate Professor

Research field (1)： Oral medicine

Research keywords (3)： Cartilage biology , 骨代謝研究 , メカノバイオロジー

Research theme for competitive and other funds (51)：

2025 - 2028 Molecular basis of cartilage health and anti-aging promoted by CCN2
2024 - 2027 Investigation on phase separation-mediated regulation of cell differentiation by droplet transpricptomics
2023 - 2027 Development of dropletomics that clarifies transcriptional regulation under liquid-liquid phase separation
2024 - 2027 糖代謝障害が招く軟骨肥大性細胞老化を介したO Aの発症機構の解明とC C N2の役割
2022 - 2025 象牙芽細胞の表面に突き出た細胞小器官の機能解析と象牙質再生への応用

2022 - 2025 非コードRNAを介した新たな軟骨ホメオスタシスとその変性メカニズムの解明

2021 - 2025 Regulation of skeletogenesis by long noncoding RNAs through CCN2

2021 - 2024 新規軟骨老化促進因子CCN3の加齢に伴った発現誘導と細胞周期停止機構の解明

2021 - 2024 長鎖非コードRNAによる骨細胞メカニカルストレス応答制御機構の解明

2020 - 2024 Pioneering chondroneutrigenomics research and its development into chondroneutrigenetics

2021 - 2023 Inverse genetics: A new methodology for the identification of key genes of somatic cell differentiation

2020 - 2023 CCN2の転写因子様機能を介した線維症のキープレイヤー筋線維芽細胞分化機構の解明

2019 - 2023 細胞アンテナによる象牙質再生への道を拓く基礎研究

2019 - 2023 Intracellular function and new extracellular signaling pathways of CCN proteins and their common molecular base

2019 - 2021 Regulation of CCN2 by an endogenous UTR blocker and its biological significance

2017 - 2020 Neutrigenomics studies on endochondral ossification and articular cartilage mainteinance/regeneration

2017 - 2020 Mechanism of onset of osteoarthritis caused by obesity and regulatory effects of CCN2

2016 - 2020 The investigation of the mechanism of regular arrangement of odontoblasts via extracellular environment sensing sensors

2017 - 2019 New potential of CCN2: Functional evaluation as a Warburg effector

2016 - 2019 Roles of CCN2 and Rab14 in the formation of extracellular matrix

2016 - 2019 Role of Sox9 and its ubiquitin ligase on the Circadian growth rhythm in chondrocytes

2015 - 2018 Analysis of the CTGF/CCN2 expression promotion system which classified cartilage regenerative therapy into the field

2015 - 2018 Mechanism and expression of CD302 as a new regulator of osteoclast maturation

2015 - 2018 Establishment of molecular basis of CCN family proteins for therapeutic use and its related translational research

2014 - 2017 Effect of CCN2 on the osteocyte function regulating the osteoclast formation, and its possibility as a novel drug of osteoporosis

2014 - 2016 The presence and its significance of non-canonical action of decoy receptors

2013 - 2016 Novel function of CCN3: A regulator of endochondral ossification

2013 - 2016 Investigation on the biological diarchy by CCN2 and CCN3 for integrated tissue development

2012 - 2015 Elucidation of molecular basis of CCN family action as masterminds and its medical application

2011 - 2013 Analysis of molecular mechanism of muscle heterotopic ossification by forming a network with CCN family proteins

2011 - 2012 A new protein transport system in cartilage: Multilayered transcytosis

2010 - 2011 The analysis of binding of CTGF/CCN2 to RANK and its effects on RANK/RANKL signaling

2009 - 2011 Development and medical application of peptide and RNA aptamers that bind to CCN2

2009 - 2011 Role of a ubiquitin ligase for Sox9 on endochondral ossification and neurological disorder

2007 - 2011 Comprehensive study on molecular basis of actions of CCN family proteins as novel signal conductors and its translational application

2008 - 2010 Clarification of molecular mechanism on the osteoclastogenesis promoted by CCN family 2/connective tissue growth factor

2007 - 2008 Regulation of CCN family gene expression via micro RNA regulatory network and its Biological signficance

2007 - 2008 Analysis of the role of cartilage-specific gene in endochondral bone formation using BAC (bacterial artificial chromosome)-transgenic mice

2007 - 2008 MMPの新機能:マトリクス合成促進因子の転写因子としての役割

2006 - 2007 軟骨から骨への置換期のCTGF/CCN2の作用メカニズムの分子レベルでの解明

2005 - 2006 Role of CCN2 as a trans-modulator in the integrated development of bone, cartilage and hematopoietic systems

2003 - 2006 The role of CTGF as a novel tissue-regenerating factor, regenerin, and its application for medical and dental tissue engineering

2002 - 2003 肥大軟骨細胞由来の成長因子CTGF/Hcs24の内軟骨性骨化における役割〜器官培養系及びin vivoでの解析〜

2002 - 2003 Molecular mechanism of temporomandibular joint osteoarthritis and gene therapy for degraded, cartilage

2002 - 2003 Functional dissection and medical application of the 4 modules in the chondrocyte-derived growth factor, ecogenin/CTGF.

2001 - 2002 軟骨成長因子エコジェニン/CTGFによる生体デザインを目指す研究

2000 - 2001 軟骨細胞におけるシンデカンおよびインテグリンを介するCTGFの作用機構の解明

2000 - 2001 Development of analytical method for each domain of CTGF/ecogenin and its clinical application.

1999 - 2000 軟骨由来成長因子エコジェニン/CTGFを用いた歯周組織再建への試み

1998 - 2000 Studies on the mechanism of actions of a cartilage-derived pleiotrophic growth factor, ecogenin/CTGF - Molecular cloning of its receptors and mechanism of inter- and intra signal transduction -

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Papers (84)：

Nguyen, X.T., Kubota, S., Takigawa, M., Nishida, T. Interaction between nuclear-translocated cellular communication network factor 2 and purine-rich box 1 regulates the expression of fibrosis-related genes. J Cell Commun Signal,. 2025. 19. 4. e70051
Soma Kato, Kazumi Kawata, Takashi Nishida, Tomomi Mizukawa, Masaharu Takigawa, Seiji Iida, Satoshi Kubota. Expression and function of CCN2-derived circRNAs in chondrocytes. Journal of Cell Communication and Signaling. 2023
Hiroaki Hochi, Satoshi Kubota, Masaharu Takigawa, Takashi Nishida. Dual roles of cellular communication network factor 6 (CCN6) in the invasion and metastasis of oral cancer cells to bone via binding to BMP2 and RANKL. Carcinogenesis. 2023
Satoshi Kubota, Harumi Kawaki, Bernard Perbal, Masaharu Takigawa, Kazumi Kawata, Takako Hattori, Takashi Nishida. Do not overwork: cellular communication network factor 3 for life in cartilage. Journal of cell communication and signaling. 2023. 17. 2. 353-359
Takashi Nishida, Satoshi Kubota, Masaharu Takigawa. Novel Cell Biological Assays for Measuring Bone 2 Remodeling Activities of CCN Proteins. Methods in molecular biology (Clifton, N.J.). 2023. 2582. 255-268

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MISC (237)：

Paing, H. M., Nishida, T., Takigawa, M., Kuboki, T., Kubota, S. Combination of low-intensity pulsed ultrasound and BMP-2 enhances the eary osteogenic differentiation commitment of mesenchymal stem cells via increased CCN1 production. 13th Workshop on the CCN Family of Genes/ Inaugural ARBIOCOM Meeting,. 2025
Xuan Thi Nguyen, X. T., Kubota, S., Takigawa, M., Nishida, T. Interaction between nuclear-translocated cellular communication network factor 2 ans Pu.1 regulates the expression of fibrosis-related genes. 13th Workshop on the CCN Family of Genes/ Inaugural ARBIOCOM Meeting,. 2025
長尾有里香, 西田崇, 久保田聡. 糖代謝障害は軟骨細胞に細胞老化と肥大化様の変化を誘導する。. 第46回岡山歯学会抄録集. 2025
Nagao, Y., Nishida, T., Kubota, S. Effect of impired glycolysis by NaF on cellular senescence and chondrocyte hypertrophy. 第98回日本生化学会抄録集. 2025
Nguyen, X. T., Kubota, S., Takigawa, M., Nishida, T. Nuclear-translovated CCN2 interacts with PU.1, and their complex regulates the fibrotic-related gene expression. 第98回日本生化学会抄録集. 2025

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Books (11)：

Novel Cell Biological Assays for Measuring Bone Remodeling Activities of CCN Proteins
Springer 2022
In vivo evaluation of cartilage regenerative effects of CCN2 protein.
Springer 2016
Cell biological assays for measuring chondrogenic activities of CCN2 protein
Springer 2016
Production of recombinant CCN2 protein by mammalian cells
Springer 2016
CCN2による骨細胞機能を標的とした新規骨粗鬆症治療薬の開発
科学研究費助成事業 2016

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Lectures and oral presentations (273)：

Expression and function of CCN2-derived circRNAs in chondrocytes.
(2023)
軟骨細胞におけるCCN2由来circRNAの発現とその機能の可能性
(第65回歯科基礎医学会 2023)
CCN6はBMP2による口腔がん細胞の上皮・間葉転換をコントロールする
(第14回日本CCNファミリー研究会 2023)
軟骨細胞におけるCCN2の核移行の意義
(第14回日本CCNファミリー研究会 2023)
線維化におけるCCN2の転写共役因子としての作用
(第55回日本結合組織学会 2023)

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Education (2)：

1995 - 1999 岡山大学大学院歯学研究科
1989 - 1995 Okayama University Dental School

Professional career (1)：

博士(歯学) (岡山大学)

Work history (5)：

2014/10 - 現在 Associate Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University
2005/09 - 2014/09 岡山大学大学院医歯薬学総合研究科助教口腔生化学分野
2004/04 - 2005/09 University of California, Los Angeles
2001/04 - 2004/03 岡山大学大学院医歯学総合研究科助手口腔生化学
1999/04 - 2001/03 岡山大学歯学部教務員

Committee career (4)：

2015 - 日本歯科基礎医学会評議員
2014 - 岡山歯学会評議員
2007 - 日本CCNファミリー研究会会場の管理、運営
日本軟骨代謝学会評議員

Awards (1)：

2011/07 - 日本骨代謝学会研究奨励賞

Association Membership(s) (7)：

日本軟骨代謝学会 , 日本CCNファミリー研究会 , 日本歯科基礎医学会 , 岡山歯学会 , International CCN Society , 日本生化学会 , 日本骨代謝学会

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