KAZUO SHINOZUKA

シノヅカカズオ | KAZUO SHINOZUKA

Affiliation and department：
Job title： Professor

Research field (1)： Bioorganic chemistry

Research theme for competitive and other funds (18)：

2014 - 2017 Development of fluorogenic probe for gene-analisis utilizing novel silylated fluorescent material
2012 - 2014 Development of fluorogenic probe for gene-analisis utilizing novel sililated fluorescent material
2006 - 2007 生体膜コレステロール組成を感知する蛍光プローブの開発
2003 - 2005 Functionalization of oligonucleotides capable to form alternate-stranded triplex containing stereoisomeric nucleotide units
2001 - 2004 Enzymatic Synthesis of Modified DNAs by PCR, and Their Application

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Papers (3)：

Shiyu Wang, Md Zakir Hossain, Tao Han, Kazuo Shinozuka, Takaaki Suzuki, Anna Kuwana, Haruo Kobayashi. Avidin-Biotin Technology in Gold Nanoparticle-Decorated Graphene Field Effect Transistors for Detection of Biotinylated Macromolecules with Ultrahigh Sensitivity and Specificity. ACS omega. 2020. 5. 46. 30037-30046
Shiyu Wang, Md Zakir Hossain, Kazuo Shinozuka, Natsuhiko Shimizu, Shunya Kitada, Takaaki Suzuki, Ryo Ichige, Anna Kuwana, Haruo Kobayashi. Graphene field-effect transistor biosensor for detection of biotin with ultrahigh sensitivity and specificity. Biosensors & bioelectronics. 2020. 165. 112363-112363
Eisuke Horigome, Michiru Fujieda, Tadashi Handa, Ayaka Katayama, Masashi Ito, Ami Ichihara, Daiki Tanaka, Navchaa Gombodorj, Shinji Yoshiyama, Arito Yamane, et al. Mutant TP53 modulates metastasis of triple negative breast cancer through adenosine A2b receptor signaling. Oncotarget. 2018. 9. 77. 34554--34566

MISC (164)：

Hiroyuki Oku, Yudai Kimoto, Nana Isomoto, Suguru Niwa, Kazuo Shinozuka, Kazuhiko Yano, Shigeyuki Kano. A NOVEL PLASMINOGEN-BINDING SEQUENCE IDENTIFIED FROM THE ROOP REGION OF Plasmodium falciparum ENOLASE. Peptide Scienece 2017. 2018. 2017. 160-161
K. Yamada, S. Watanabe, S. Watanabe, T. Takahashi, T. Moriguchi, H. Oku, N. S. Ishioka, K. Shinozuka. Synthesis and properties of silylated phenylalanine derivatives. Peptide Science 2015. 2016. 2015. 93-94
Jakir Ahmed Chowdhury, Tomohisa Moriguchi, Kazuo Shinozuka. Pseudo-Dumbbell-Type Molecular Beacon Probes Bearing Modified Deoxyuridine Derivatives and a Silylated Pyrene as a Fluorophore. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN. 2015. 88. 3. 496-502
Jakir Ahmed Chowdhury, Tomohisa Moriguchi, Kazuo Shinozuka. Pseudo-Dumbbell-Type Molecular Beacon Probes Bearing Modified Deoxyuridine Derivatives and a Silylated Pyrene as a Fluorophore. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN. 2015. 88. 3. 496-502
渡邊早貴, 渡辺茂樹, 山田圭一, 奥浩之, 森口朋尚, 石岡典子, 篠塚和夫. シリル化フェニルアラニンの合成と放射性臭素による標識化. 日本化学会講演予稿集. 2015. 95th. 4

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Patents (5)：

シリル化蛍光剤を結合した核酸検出プロ-ブ、及び当該プロ-ブによる核酸の検出方法
含ケイ素蛍光化合物および該化合物を用いた蛍光標識剤
Inhibitors for Replication of Retroviruses and for The Expression of On Cogene Products. U. S. Patent 5,264,423 and 5,276,019
Inhibitors for Replication of Retroviruses and for the Expression of Oncogene Products
Inhibitors for Replication of Retroviruses and for The Expression of On Cogene Products. U. S. Patent 5,264,423 and 5,276,019

Books (4)：

Pyrene: Chemical Properties, Biochemistry Applications and Toxic Effects,
Nova Science Publishers Inc. 2013
Pyrene: Chemical Properties, Biochemistry Applications and Toxic Effects,
Nova Science Publishers Inc. 2013
ケミカルエンジニアリング
化学工業社 2009
細胞工学ハンドブック(共著)
朝倉書店 2000

Lectures and oral presentations (85)：

電子供与基を導入したシリル化ピレン及びそれを導入した人工核酸の開発
(日本化学会第98春季年会 2018)
ベンゾフェノンを導入した光架橋性人工核酸の開発
(日本化学会第98春季年会 2018)
Improvement of Sequence Discrimination Ability of Molecular Beacons by the Addition of Short Oligomers
(The 44th International Symposium on Nucleic Acids Chemistry 2017)
ホスホチロシンを用いた新しいペプチド抗原の検討
(日本化学会第97春季年会 2017)
熱帯熱マラリア原虫エノラーゼの部分ペプチドを用いた、ヒトプラスミノーゲン結合配列とプラスミン活性化の研究
(日本化学会第97春季年会 2017)

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Works (6)：

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Education (4)：

- 1982 オーストラリア国立ジョーンカーティン医学研究校大学院医薬化学研究科医薬化学
- 1982 Australian National University. The John Curtin School of Medical Research Medicinal Chemistry Medicinal Chemistry
- 1977 Kumamoto University School of Pharmacy
- 1977 Kumamoto University Faculty of Pharmaceutical Science

Professional career (1)：

Work history (11)：

2000/04 - 2019/03 Gunma University Graduate School of Science and Technology Professor
1993 - 2000 Gunma University
1993 - 2000 Gunma University Assistant Professor
1988 - 1993 Gunma University
1988 - 1993 Gunma University Faculty of Engineering Research Assistant

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Committee career (6)：

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Awards (1)：

2021/11 - Japan Society of Nucleic Acids Chemistry The Award of Japan Society of Nucleic Acids Chemistry

Association Membership(s) (7)：

日本核酸医薬学会 , 日本核酸化学会 , アメリカ化学会 , アンチセンスDNA/RNA研究会 , 日本薬学会 , 日本化学会 , 国際核酸化学会

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