Research keywords (7)：
alopecia areata
, autoimmune disease
, immune checkpoint inhibitor
, flow cytometry
, Drug-induced hypersensitivity syndrome
, severe drug eruption
, regulatory T cell
Research theme for competitive and other funds (20)：
2024 - 2027 T細胞プロファイルを指標とした経口JAK阻害薬の治療効果予測因子の確立
2018 - 2021 Elucidation of the immediate suppression mechanism of steroid pulse therapy mediated by innate immune cells
2017 - 2021 Clinical and immunological analysis of onset of dipeptidyl peptidase-4 inhibitor associated bullous pemphigoid
2016 - 2020 Attempt to regenerate skin appendages using reconstituted embryonal-like skin equivalent using human induced pluripotent stem cells
2015 - 2018 Why does Stevens-Johnson syndrome develop with mycoplasma pneumonia?
2012 - 2015 The role of patrolling monocytes in inflammary dermatoses in which herpesviruses can trigger
2012 - 2015 Why the occurrence of eczema herpeticum caused by an extensive disseminated cutaneous infection with HSV-1 is associated with the exacerbation of atopic dermatitis lesion?
2010 - 2011 The elucidation of the mechanism and pathogenesis of severe drug eruption.
2009 - 2011 Analysis of factors that regulate effector T cell and regulatory T cell recruitment to the skin
2008 - 2009 Functional analysis of regulatory T cells in patient of drug hypersensitivity syndrome
2007 - 2008 Regulation of skin-directed migration of regulatory T cells by fucosyltransferase
2007 - 2008 Pathomechanisms of viral reactivation and inhibition of B cell differentiation associated with regulatory T cell
2005 - 2006 The role of fucosyltransferases in skin-homing of virus-specific T cells
2005 - 2006 皮膚親和性CD8Tリンパ球の分化とフコース転移酵素群の発現解析
2004 - 2005 Analysis of mechanisms for counter-regulation between TLR and FcεRI using model mice for atopic dermatitis
2004 - 2005 T cell homing control by fucosyltransferases VII/IV
2003 - 2004 Analysis in differentiation and function of virus-specific T cells in the skin
2003 - 2004 Th1/Th2細胞における皮膚ホーミングレセプター発現機序に関する研究
2001 - 2002 T細胞の皮膚ホーミングレセプターとそれを制御する糖転移酵素の発現動態
2001 - Drug eruption and cutaneous T cells
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Papers (35)：
Ryo Takahashi, Misaki Kinoshita-Ise, Yoshimi Yamazaki, Masahiro Fukuyama, Manabu Ohyama. Increase in CD8+ Effector Memory T Cells Re-Expressing CD45RA Correlates with Intractability of Severe Alopecia Areata. The Journal of investigative dermatology. 2024
Yoshiko Mizukawa, Yumi Aoyama, Hayato Takahashi, Ryo Takahashi, Tetsuo Shiohara. Risk of Progression to Autoimmune Disease in Severe Drug Eruption: Risk Factors and the Factor-Guided Stratification. The Journal of investigative dermatology. 2022. 142. 3 Pt B. 960-968
Ryo Takahashi, Tetsuo Shiohara, Yoshiko Mizukawa. Monocyte-Independent and -Dependent Regulation of Regulatory T-Cell Development in Mycoplasma Infection. The Journal of infectious diseases. 2021. 223. 10. 1733-1742
Yorihisa Moro, Yasunao Kogashiwa, Hiroyuki Sakurai, Ryo Takahashi, Toru Kimura, Masataka Hirasaki, Yoshifumi Matsumoto, Masashi Sugasawa, Naoyuki Kohno. In Vitro Study of the Anti-cancer Effect of Alternate-day 5-Fluorouracil in Head and Neck Cancer Cells. Anticancer research. 2019. 39. 11. 6041-6047
Pathomechanisms of lichen planus. Autoimmunity elicited by cross-reactive T cells. In Current Directions in Autoimmunity: Dermatologic Autoimmunity. Nickoloff, B.J. and Nestle, F., eds.
Karger Press 2008
Induced Hypersensitivity Syndrome and Viral Reactivation. Drug Hypersensitivity
Karger 2007
Increase in CD8+ effector memory cells re-expressing CD45RA (TEMRA) reflects disease activity and enables early prediction of therapeutic outcome in rapidly progressive alopecia areata
(International Societies for Investigative Dermatology Meeting 2023 2023)
Changes in peripheral blood mononuclear cell subsets putatively predict response to i.v. steroid pulse therapy to severe alopecia areata
(The 47th Annual Meeting of the Japanese Society for Investigative Dermatology 2022)
