Rchr
J-GLOBAL ID：200901073681796520   Update date: Feb. 01, 2024

Kuroda Masayuki

クロダ マサユキ | Kuroda Masayuki
Affiliation and department：
Chiba University Hospital

About Chiba University Hospital


Job title： Research assistant
Homepage URL  (1)： https://www.ho.chiba-u.ac.jp/dept/future/
Research field  (5)： Clinical pharmacy ,  Virology ,  Pharmacology ,  Pharmaceuticals - health and biochemistry ,  Functional biochemistry
Research keywords  (8)： LCAT欠損症 ,  遺伝子治療 ,  Regenerative Medicine ,  脂質異常症 ,  脂肪細胞 ,  gene therapy ,  tumorgenesis ,  Epstein-Barr virus
Research theme for competitive and other funds  (26)：
  • 2023 - 2026 Development of adipocytes for gene therapy that avoids cellular stress due to overexpression of therapeutic proteins
  • 2022 - 2025 Development of Innovative Fat Transplantation Based on Single Cell Analysis and Computational Biology of Subcutaneous Adipose Tissue-Derived Cells
  • 2020 - 2023 エピジェネティクス編集技術を用いた革新的脂肪移植治療法開発に資する基盤的研究
  • 2020 - 2023 Study on improvement of transplantation efficiency of adipocyte gene therapy product by approach from engrafted cells after transplantation
  • 2019 - 2023 Establishment of epignenetic genome-edited adipocyte for multiple purposes
Show all
Papers (43)：
  • Kentaro Sugisaki, Takahiro Uchida, Sachiko Iwama, Masaaki Okihara, Isao Akashi, Yu Kihara, Osamu Konno, Masayuki Kuroda, Junki Koike, Hitoshi Iwamoto, et al. Glomerular lipidosis as a feature of renal-limited macrophage activation syndrome in a transplanted kidney: a case report. BMC nephrology. 2023. 24. 1. 329-329
  • Yasuaki Takeji, Hayato Tada, Masatsune Ogura, Atsushi Nohara, Masa-aki Kawashiri, Shizuya Yamashita, Mariko Harada-Shiba, Mariko Harada-Shiba, Shun Ishibashi, Shinji Yokoyama, et al. Clinical Characteristics of Homozygous Familial Hypercholesterolemia in Japan. JACC: Asia. 2023
  • Ryotaro Teranaka, Hiroshi Fujimoto, Takahito Masuda, Masayuki Kuroda, Yasuyuki Aoyagi, Takeshi Nagashima, Mamoru Takada, Junta Sakakibara, Hideyuki Yamada, Hiroto Yamamoto, et al. Ex vivo dual gene therapy using human adipocytes secreting anti-HER2 antibody on HER2-positive xenograft tumor models. Breast cancer (Tokyo, Japan). 2023
  • Masayuki Aso, Tokuo T. Yamamoto, Masayuki Kuroda, Jun Wada, Yoshitaka Kubota, Ko Ishikawa, Yoshiro Maezawa, Naoya Teramoto, Ayako Tawada, Sakiyo Asada, et al. First-in-human autologous implantation of genetically modified adipocytes expressing LCAT for the treatment of familial LCAT deficiency. Heliyon. 2022. 8. 11. e11271-e11271
  • Tadashi Takeda, Tsubasa Ide, Daishi Okuda, Masayuki Kuroda, Sakiyo Asada, Mika Kirinashizawa, Misato Yamamoto, Junko Miyoshi, Koutaro Yokote, Naohiro Mizutani. A novel homozygous frameshift mutation in the APOA1 gene associated with marked high-density lipoprotein deficiency. Journal of clinical lipidology. 2022
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MISC (60)：
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Patents (1)：
  • 遺伝子治療用脂肪細胞の調製のための外来遺伝子の導入に適した細胞集団かどうかを判定する方法
Books (4)：
  • 遺伝子治療開発研究ハンドブック第2版
    株式会社 エヌ・ティー・エス 2023
  • 再生医療等製品の開発と実用化展望
    株式会社 シーエムシー出版 2016
  • 先天代謝異常ハンドブック
    株式会社 中山書店 2013
  • EBウイルス実験法 2.通常のウイルス学的手法によるEBウイルス実験法
    「EBウイルス」,診断と治療社,東京 2003
Lectures and oral presentations  (24)：
  • Sustained LCAT replacement in patient with familial LCAT deficiency in clinical trial of ex vivo gene/cell therapy using autologous preadipocytes.
    (ESGCT 30TH ANNUAL CONGRESS 2023)
  • First in human clinical trial of ex vivo gene/cell therapy of familial LCAT deficiency.
    (2023)
  • 家族性LCAT欠損症を対象としたex vivo脂肪細胞遺伝子治療のfirst in human試験
    (第29回日本遺伝子細胞治療学会学術集会 2023)
  • LCAT-GMACの移植による家族性LCAT欠損症を対象としたFirst in human臨床試験
    (第52回日本動脈硬化学会総会・学術集会 2023)
  • One and Done Gene and Cell Therapy for Familial LCAT Deficiency Using LCAT Gene Transduced Human Adipocytes.
    (The American Society of Gene & Cell Therapy (ASGCT), 26th Annual Meeting 2023)
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Education (4)：
  • - 1988 Okayama University
  • - 1988 Okayama University Graduate School, Division of National Science and Technology
  • - 1983 Okayama University Faculty of Pharmaceutical Sciences Department of Pharmacy
  • - 1983 Okayama University Faculty of Pharmaceutical Science
Professional career (1)：
  • Ph.D. (Okayama University)
Association Membership(s) (9)：
日本遺伝子細胞治療学会 ,  日本薬学会 ,  日本分子生物学会 ,  日本ウイルス学会 ,  THE JAPANESE CONFERENCE ON THE BIOCHEMISTRY OF LIPIDS ,  JAPAN SOCIETY FOR THE STUDY OF OBESITY ,  JAPAN ATHEROSCLEROSIS SOCIETY ,  JAPANESE SOCIETY FOR INHERITED METABOLIC DISEASES ,  THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
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