Kubota Akira

クボタアキラ | Kubota Akira

Affiliation and department：
Job title： Professor
Other affiliations (2)：

Obihiro University of Agriculture and Veterinary Medicine Department of Basic Veterinary Medicine
Obihiro University of Agriculture and Veterinary Medicine Diagnostic Center for Animal Health and Food Safety

Homepage URL (2)： https://kaken.nii.ac.jp/ja/search/?qm=60432811 , http://www.rakuno.ac.jp/dep05/112/

Research field (8)： Developmental biology , Pharmaceuticals - health and biochemistry , Veterinary medicine , Landscape science , Environmental agriculture , Environmental effects of chemicals , Environmental effects of radiation , Environmental impact assessment

Research keywords (20)：希少猛禽類 , 薬物代謝 , 内分泌撹乱化学物質 , 保全科学 , Mycotoxin , Ecotoxicology , Omics , Endangered species , Toxicology , Environmental Pollutants , Nuclear Receptors , Biomarker , Wildlife , Zebrafish , Cytochrome P450 , Risk Analysis , Environmental Chemistry , Environmental Pollution , Developmental Toxicology , Environmental Toxicology

Research theme for competitive and other funds (21)：

2023 - 2027 Spatiotemporal trend analysis and ecological risk assessment of monitoring and emerging environmental chemicals in the Asia-Pacific region
2023 - 2026 Development and clinical application of a non-invasive drug sensitivity assessment method for ex situ conservation of threatened avian species
2022 - 2025 魚類胚の全身スクリーニングと統合オミクスを基盤とした化学物質の毒性発現機序解明
2020 - 2025 Elucidation of environmental contamination status and bioaccumulation features of emerging perfluoroalkyl substances (PFASs) and assessment of their ecotoxicological effects
2020 - 2024 Development of risk assessment method and present of brain transfer by ionic environmental contaminants using fish as an indicator

2020 - 2023 トリアセチルフサリニンCで見いだされた鉄イオン獲得以外の新たな機能

2019 - 2022 Biomagnification mechanism, spatiotemporal trend, and risk assessment of legacy and new environmental pollutants in various aquatic animal species

2019 - 2022 Assessment of developmental toxicities caused by chemical substances and elucidation of their mechanisms based on the quantitative phenotype screening using small fish

2018 - 2022 Evaluation of Chemical Susceptibility Diversity by mlAOP Concept and its Application to Understanding Insecticide Poisoning

2015 - 2019 Understanding of molecular mechanisms of chemically-induced toxicities and risk evaluation using zebrafish

2014 - 2019 Multiple Omics Analysis to Understand the Species Differences in Chemical-intracellular Receptor Signaling Disruption

2017 - 2018 希少鳥類の保全に向けた薬理・毒性学的アプローチと臨床応用~タンチョウを例に~

2017 - 2018 魚類のエストロゲン受容体サブタイプに着目した新世代ビスフェノール類の内分泌攪乱性の評価

2015 - 2016 栄養生理機能マルチセンシングによる搾乳ロボットを用いた精密飼養管理システムの開発

2014 - 2015 魚類の核内受容体PXRシグナル経路の撹乱に関わる新規分子機構とその毒性学的意義

2014 - 2015 化学物質曝露により活性化される魚類の核内受容体とその標的遺伝子の探索

2012 - 2014 ゼブラフィッシュの核内受容体PXRに着目した化学物質生体影響評価システムの開発

2009 - 2010 魚類のダイオキシン動態及び毒性におけるチトクロームP450の新たな役割

2007 - 2009 魚類のダイオキシン動態及び毒性におけるチトクロームP450の新たな役割

2003 - 2005 ダイオキシン類による野生鳥類の汚染とその影響評価

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Papers (48)：

Rehab Youssef Salama Ahmed, Rumi Tanoue, Xing Chen, Yusuke K Kawai, Akira Kubota. Assessment of developmental toxicity and the potential mode of action underlying single and binary exposure to estrogenic endocrine disrupting chemicals in zebrafish (Danio rerio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023. 277. 109821-109821
Akira Kubota, Masashi Hirano, Yuka Yoshinouchi, Xing Chen, Michiko Nakamura, Yumi Wakayama, Jae Seung Lee, Haruhiko Nakata, Hisato Iwata, Yusuke K Kawai. In vivo and in silico assessments of estrogenic potencies of bisphenol A and its analogs in zebrafish (Danio rerio): Validity of in silico approaches to predict in vivo effects. Comparative Biochemistry and Physiology. Toxicology & pharmacology : CBP. 2023. 269. 109619-109619
Xing Chen, Masashi Hirano, Hiroshi Ishibashi, Jae Seung Lee, Yusuke K Kawai, Akira Kubota. Efficient in vivo and in silico assessments of antiandrogenic potential in zebrafish. Comparative Biochemistry and Physiology. Toxicology & pharmacology : CBP. 2023. 264. 109513-109513
Jae Seung Lee, Yusuke K Kawai, Yuri Morita, Adrian Covaci, Akira Kubota. Estrogenic and growth inhibitory responses to organophosphorus flame retardant metabolites in zebrafish embryos. Comparative Biochemistry and Physiology. Toxicology & pharmacology : CBP. 2022. 256. 109321-109321
Hiroshi Ishibashi, Masaya Uchida, Masashi Hirano, Taka Hayashi, Ryoko Yamamoto, Akira Kubota, Nobuhiro Ichikawa, Yasuhiro Ishibashi, Nobuaki Tominaga, Koji Arizono. In vivo and in silico analyses of estrogenic potential of equine estrogens in medaka (Oryzias latipes). The Science of the Total Environment. 2021. 767. 144379-144379

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MISC (17)：

川合佑典, 池中良徳, 池中良徳, 生城真一, 西川美宇, 一色乃亜, 武田一貴, 中山翔太, 中山翔太, 久保田彰, et al. Evolutionary history of UGT genes involved in xenobiotic metabolism in mammals and birds and their relationship to plants. 日本進化学会大会プログラム・講演要旨集(Web). 2023. 25th
川合佑典, 池中良徳, 中山翔太, 久保田彰, 石塚真由美. Evolutionary analysis of UDP-glucuronosyltransferase genes in vertebrates using a genome database. 環境ホルモン学会研究発表会プログラム・要旨集. 2021. 23rd (Web)
久保田彰. 発達期ゼブラフィッシュにおけるリン酸エステル系難燃剤の代謝物の発生毒性. Endocr Disrupter News Lett. 2020. 22. 4. 4-4
石橋弘志, 平野将司, 内田雅也, 久保田彰, 石橋康弘, 冨永伸明, 有薗幸司. エコトキシコロジーヒメダカ胚に対するエクインエストロゲン類のin silico及びin vivoエストロゲン様作用. 環境ホルモン学会研究発表会要旨集. 2019. 22回. 32-32
川合佑典, 新屋惣, 中山翔太, 池中良徳, 石塚真由美, 久保田彰. 鳥類におけるUGT1E遺伝子の進化と食性の関わり. 日本進化学会大会プログラム・講演要旨集(Web). 2019. 21st

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Books (4)：

獣医毒性学<第二版>
近代出版 2020 ISBN:9784874022603
ホルモンと臨床
医学の世界社 2011
最新獣医公衆衛生
チクサン出版社 2009 ISBN:9784885004278
Interdisciplinary Studies on Environmental Chemistry-Biological Responses to Chemical Pollutants(共著)
TERRAPUB 2008 ISBN:9784887041455

Lectures and oral presentations (26)：

タンチョウにおける異物代謝関連遺伝子の同定と定量
(日本獣医学会学術集会講演要旨集 2018)
Contamination status of mycotoxins in dent corn silage caused by typhoon damage in Tokachi
(Annual Meeting of the Japanese Society of Toxicology 2018)
Assessment of endocrine disruption potency of bisphenol A replacement using zebrafish
(Annual Meeting of the Japanese Society of Toxicology 2018)
ゼブラフィッシュをモデルとしたin silicoおよびin vivo解析によるビスフェノール類のエストロゲン様作用の評価
(日本内分泌かく乱化学物質学会研究発表会要旨集 2017)
ゼブラフィッシュを用いたin silicoおよびin vivo解析によるビスフェノール類のエストロゲン様作用の評価
(環境化学討論会要旨集(CD-ROM) 2017)

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Professional career (1)：

博士(農学) (愛媛大学)

Work history (11)：

2023/05 - 現在 Obihiro University of Agriculture and Veterinary Medicine Department of Basic Veterinary Medicine Professor
2017/04 - 現在 Obihiro University of Agriculture and Veterinary Medicine
2014/03 - 現在 Obihiro University of Agriculture and Veterinary Medicine Diagnostic Center for Animal Health and Food Safety Associate Professor
2014/03 - 2017/03 Obihiro University of Agriculture and Veterinary Medicine Department of Animal and Food Hygiene
2012/04 - 2014/02 Woods Hole Oceanographic Institution Biology Department JSPS Postdoctoral Fellow for Research Abroad

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Committee career (11)：

2023/01 - 現在厚生労働省薬事・食品衛生審議会専門委員(動物用医薬品残留問題調査会)
2023 - 現在第2回環境化学物質3学会合同大会実行委員
2019/12 - 現在環境ホルモン学会第23回環境ホルモン学会研究発表会実行委員
2019/09 - 現在日本環境毒性学会幹事
2016 - 現在日本比較薬理学・毒性学会プログラム企画委員

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Awards (12)：

2021/10 - The International Congress of Asian Society of Toxicology Excellent Paper Award
2021/09 - 日本内分泌撹乱物質学会森田賞
2021/09 - 日本内分泌撹乱物質学会森田賞
2021/03 - 日本環境毒性学会若手奨励賞
2019/09 - 日本環境毒性学会ポスター賞

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Association Membership(s) (10)：

内外環境応答・代謝酵素研究会 , Society of Toxicology , 北海道薬物作用談話会 , THE JAPANESE SOCIETY OF TOXICOLOGY , 日本比較薬理学・毒性学会 , JAPANESE SOCIETY OF VETERINARY SCIENCE , JAPAN SOCIETY FOR ENVIRONMENTAL CHEMISTRY , 日本環境毒性学会 , Japan Society of Endocrine Disrupter Research , Society of Environmental Toxicology and Chemistry

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