Rchr
J-GLOBAL ID：200901074055911977
Update date: Jun. 13, 2024
Ogata Tsutomu
オガタ ツトム | Ogata Tsutomu
Affiliation and department：
Job title：
Research FProfessor
Research field (3)：
Genetics
, Metabolism and endocrinology
, Fetal medicine/Pediatrics
Research keywords (3)：
遺伝学
, 内分泌
, Pediatric endocrinology
Research theme for competitive and other funds (25)：
- 2020 - 2023 多因子疾患としての性分化疾患・生殖機能障害発症機序の解明
- 2017 - 2022 Molecular basis of human sex spectrum
- 2017 - 2020 Identification of the germline-derived GNAS gain-of-function mutations and clarification of the novel mechanism leading to GNAS loss-of-function
- 2015 - 2018 Epigenotype-phenotype analysis of Silver-Russell syndrome pathogenesis mechanism
- 2014 - 2017 Epigenetic analyses in patients with imprinting disorders conceived by assisted reproduction technologies
- 2014 - 2017 Genetic mechanism of split-hand/foot malformation with or without long bone deficiency
- 2013 - 2016 Clarification of (epi)genetic mechanisms involved in the development of human imprinting disorders
- 2013 - 2016 The role of hydroxymethylation in congenital anomaly syndromes caused by aberrant methylation
- 2013 - 2016 Combined action of environmental and genetical factors on mail genital abnormalities
- 2010 - 2015 "Molecular mechanisms for establishment of sex differences"
- 2010 - 2015 Clarification of underlying factors involved in the establishment of sex differences
- 2010 - 2015 Demonstration of Novel Brain Molecular Mechanisms Regulating Reproduction
- 2010 - 2012 Clarification of (epi)genetic causes leading to the development of human imprinting disorders
- 2010 - 2012 Research of genetic factor for childhood-onset Type 1 diabetes
- 2008 - 2010 Elucidation of the pathogenic mechanism and the clinical spectrum of disorders associated with imprinted genes on human chromosome 14
- 2008 - 2010 Molecular mechanism leading to impaired sexual differentiation and reproductive failure in patients with MAMLD mutations
- 2007 - 2009 Novel sex development gene CXorf6 : determination of clinical spectrum in mutation positive patients and clarification of underlying factors
- 2007 - 2008 Molecular genetic analysis of Silver-Russell syndrome and intrauterine growth retardation
- 2004 - 2008 Comprehensive mutation and susceptibility analyses and its clinical application in disorders of sex development and reproductive dysfunction
- 2005 - 2006 Clarification of the genetic mechanisms underlying the regulation for the expression of SHOX, a causative gene for short stature and sdyschomndrosteosis
- 2003 - 2004 Clarification of genetic mechanisms leading to the whole phenotype in Turner syndrome
- 2000 - 2002 CLARIFICATION OF CLINICAL ROLE AND GROWTH REGULATION MECHANISM OF THE SHOX GENE ON THE HUMAN PSEUDOAUTOSOMAL REGION
- 1992 - 1993 Molecular studies on the pathogenesis of idiopathic short stature : Analysis of a growth gene(s) on the X chromosome short arm.
- 臨床および分子遺伝学
- Molecular Endocrinology
Show all
Papers (513)：
-
Kaori Yamoto, Hirotomo Saitsu, Yumiko Ohkubo, Masayo Kagami, Tsutomu Ogata. Pathogenic sequence variant and microdeletion affecting HMGA2 in Silver-Russell syndrome: case reports and literature review. Clinical epigenetics. 2024. 16. 1. 73-73
-
Atsushi Hattori, Atsuhito Seki, Naoto Inaba, Kazuhiko Nakabayashi, Kazue Takeda, Kuniko Tatsusmi, Yasuhiro Naiki, Akie Nakamura, Keisuke Ishiwata, Kenji Matsumoto, et al. Expression levels and DNA methylation profiles of the growth gene SHOX in cartilage tissues and chondrocytes. Scientific reports. 2024. 14. 1. 8069-8069
-
Ryota Kawakami, Takuya Hiraide, Kazuki Watanabe, Sachiko Miyamoto, Kota Hira, Kazuyuki Komatsu, Hidetoshi Ishigaki, Kimiyoshi Sakaguchi, Masato Maekawa, Keita Yamashita, et al. RNA sequencing and target long-read sequencing reveal an intronic transposon insertion causing aberrant splicing. Journal of human genetics. 2024. 69. 2. 91-99
-
Yohei Masunaga, Hiroyuki Ono, Yasuko Fujisawa, Kiyosu Taniguchi, Hirotomo Saitsu, Tsutomu Ogata. Sotos syndrome with marked overgrowth in three Japanese patients with heterozygous likely pathogenic NSD1 variants: case reports with review of literature. Endocrine journal. 2024. 71. 1. 75-81
-
Takuya Hiraide, Taiju Hayashi, Yusuke Ito, Rei Urushibata, Hiroshi Uchida, Ryoichi Kitagata, Hidetoshi Ishigaki, Tsutomu Ogata, Hirotomo Saitsu, Tokiko Fukuda. Case Report: Novel compound heterozygous TPRKB variants cause Galloway-Mowat syndrome. Frontiers in pediatrics. 2024. 12. 1360867-1360867
ｍore...
MISC (852)：
-
川嶋 明香, 湯野 暁子, 佐野 伸一朗, 中村 明枝, 石渡 啓介, 川崎 友之, 細道 一善, 中林 一彦, 阿久津 英憲, 才津 浩智, et al. GNAS遺伝子座へのレトロトランスポゾン挿入によって発症した偽性副甲状腺機能低下症1B型兄妹例. 日本内分泌学会雑誌. 2023. 99. 1. 316-316
-
佐野 伸一朗, 岩本 彰太郎, 松下 理恵, 加藤 芙弥子, 増永 陽平, 藤澤 泰子, 緒方 勤. GNASスプライスバリアントによる偽性副甲状腺機能低下症Iaの1例. 日本内分泌学会雑誌. 2023. 99. 1. 387-387
-
増永 陽平, 西村 玄, 高橋 孝治, 鹿島田 健一, 岡本 伸彦, 大場 大樹, 大橋 博文, 池野 充, 深見 真紀, 才津 浩智, et al. NANS-CDG3例の臨床および遺伝学的所見. 日本内分泌学会雑誌. 2023. 99. 1. 390-390
-
小川 達雄, 有安 宏之, 澤部 史一, 早房 良, 齋藤 洸平, 酒井 勇輝, 姜 知佳, 小杉 理英子, 小谷 仁人, 臼井 健, et al. FGFR1/RRM2Bに同時に変異を伴う低ゴナドトロピン性性腺機能低下症の1例. 日本内分泌学会雑誌. 2023. 99. 1. 412-412
-
緒方 勤. 【小児科医が知っておくべき エピジェネティクスの基本知識】内分泌疾患 インプリンティングとSilver-Russell症候群について. 小児科. 2023. 64. 5. 471-479
ｍore...
Lectures and oral presentations (46)：
-
Genomic imprinting and its clinical relevance: lessons from Kagami-Ogata syndrome and Temple syndrome
(2023)
-
IGF2: a paternally expressed gene essential for pre- and post-natal growth and placental development.
(Symposium Novel gene discoveries in Mendelian diseases. 2018 International Joint Conference on Genetics & Medicine (Genetic Society of Korea, Korean Society of Medical Genetics & Genomics, and East-Asian Union of Human Genetics Society). 2018)
-
Environmental Impacts on Male Sexual Differentiation.
(Symposium Global Human Exposure to Endocrine Disrupting Chemicals. The 16th International Congress of Endocrinology & the Endocrine Society’s 96th Annual Meeting & Expo. 2014)
-
Aromatase Excess Syndrome as a Model for Genomic Disorder: Identification of Molecular Bases and Phenotypic Determinants.
(Kaichi Kida Session. The 7th Asia Pacific Paediatric Endocrine Society Meeting. 2012)
-
Genetics of DSD (Disorders of sex development).
(Disorders of sex development. The 15th International and 14th European Congress of Endocrinology (ICE/ECE). 2012)
ｍore...
Education (1)：
- 1975 - 1981 Keio University School of Medicine
Professional career (1)：
Work history (11)：
- 2021/04 - 現在 Hamamatsu Medical Center Department of Pediatrics
- 2021/04 - 現在 Hamamatsu University School of Medicine Faculty of Medicine Research Professor
- 2019/04 - 現在 Hamamatsu University School of Medicine
- 2014/04 - 現在 Hamamatsu University School of Medicine
- 2011/05 - 現在 国立大学法人浜松医科大学小児科学講座教授
- 2016/04 - 2019/03 Hamamatsu University School of Medicine
- 2002/10 - 2011/05 国立成育医療研究センター研究所分子内分泌研究部部長
- 1992/09 - 2002/09 東京電力病院小児科
- 1989/10 - 1992/07 英国王立癌研究所ヒト分子遺伝学研究部
- 1983/08 - 1989/08 群馬県総合太田病院小児科・NICU医師
- 1981/11 - 1983/07 慶應義塾大学医学部附属病院小児科
Show all
Committee career (11)：
- 2021/11 - 現在 日本小児内分泌学会 監事
- 2021/11 - 現在 日本小児遺伝学会 監事
- 1991/04 - 現在 日本人類遺伝学会 評議員
- 2012/04 - 2021/10 日本小児遺伝学会 理事
- 2002/04 - 2021/10 日本小児内分泌学会 理事
- 2017/04 - 2021/03 日本内分泌会 理事
- 2015/04 - 2021/03 日本内分泌学会東海支部 理事
- 2013/04 - 2021/03 日本ステロイドホルモン学会 理事
- 2011/06 - 2021/03 日本小児科学会静岡地方会 理事長
- 2016/04 - 2020/03 日本生殖内分泌学会 理事長
- 2014/04 - 2017/09 日本小児内分泌学会 理事長
Show all
Awards (11)：
- 2019/05 - 日本内分泌学会学会賞
- 2017/09 - 第11回(2017年度)日本小児内分泌学会学会賞
- 2017/09 - 第6回(2017年度)ヨーロッパ小児内分泌学会国際賞ESPE International Award
- 2016/10 - 第46回(2016年度)日本人類遺伝学会学会賞
- 2010/10 - 第1回日本小児内分泌学会藤枝賞
- 2008/08 - The 9th Royan International Research Award
- 2004/03 - 第4回小児医学川野賞
- 2001/06 - 米国内分泌学会雑誌優秀論文賞
- 1997/04 - 第100回記念日本小児科学会優秀演題賞
- 1996/01 - 慶應義塾大学 第1回慶應義塾大学医学振興基金特別奨励研究賞
- 1989/11 - 慶應義塾大学医学部 三四会賞
Show all
Association Membership(s) (11)：
日本アンドロロジー学会
, 日本生殖発生学会
, 日本小児科学会静岡地方会
, JAPAN PEDIATRIC SOCIETY
, 日本人類遺伝学会
, 日本小児遺伝学会
, 日本内分泌学会東海支部
, The Japan Endocrine Society
, 日本ステロイドホルモン学会
, 日本生殖内分泌学会
, 日本小児内分泌学会
