Research theme for competitive and other funds (9)：
1989 - 1989 自然抵抗性抗がんエフェクター系の作用機作と、その活性化による制がん効果
1988 - 1988 自然抵抗性抗がんエフェクター系の作用機作とその活性化による制がん効果
1987 - 1987 自然抵抗性抗がんエフェクター系の作用機作と,その活性化による制がん効果
宿主細胞に対するマクロライドの作用とその機序の解明
ヒトマクロファージにおけるHIV-1及び結核菌の増殖制御機構の解析
ヒト単球由来マクロファージの多様性と機能に関する研究
マクロファージの分化と活性化
Macrophage heterogeneity
Differentiation and activation of macrophages
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Papers (17)：
Tran DH, Sugamata R, Hirose T, Suzuki S, Noguchi Y, Sugawara A, Ito F, Yamamoto T, Kawachi S, Akagawa KS, et al. Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with virus internalization process. The Journal of antibiotics. 2019. 72. 10. 759-768
Sugamata R, Sugawara A, Hirose T, Dat T, Akagawa KS, Omura S, Sunazuka T, Suzuki K. Anti-influenza A/H1N1 virus activity by 16-membered macrolide antibiotics and development of novel therapeutic drug based on macrolide derivatives. The Japanese Journal of Antibiotics. 2017. 70. 13-18
Akihiro Sugawara, Hideaki Shima, Akito Sueki, Tomoyasu Hirose, Hidehito Matsui, Hayato Nakano, Hideaki Hanaki, Kiyoko S. Akagawa, Satoshi Omura, Toshiaki Sunazuka. Non-antibiotic 12-membered macrolides: design, synthesis and biological evaluation in a cigarette-smoking model. JOURNAL OF ANTIBIOTICS. 2016. 69. 4. 319-326
Ryuichi Sugamata, Akihiro Sugawara, Tomokazu Nagao, Koya Suzuki, Tomoyasu Hirose, Ki-ichi Yamamoto, Masamichi Oshima, Kazuo Kobayashi, Toshiaki Sunazuka, Kiyoko S. Akagawa, et al. Leucomycin A(3), a 16-membered macrolide antibiotic, inhibits influenza A virus infection and disease progression. JOURNAL OF ANTIBIOTICS. 2014. 67. 3. 213-222
Akihiro Sugawara, Akito Sueki, Tomoyasu Hirose, Hideaki Shima, Kiyoko S. Akagawa, Satoshi Omura, Toshiaki Sunazuka. Novel 12-membered non-antibiotic macrolides, EM900 series with anti-inflammatory and/or immunomodulatory activity; synthesis, structure-activity relationships and in vivo study. JOURNAL OF ANTIBIOTICS. 2012. 65. 9. 487-490
T. Nei, S. Urano, C. Kaneko, N. Motoi, J. Takizawa, R. Tazawa, K. Nakagaki, K. Akagawa, B. Trapnell, K. Nakata. Mechanisms For Excessive Production Of GM-CSF Autoantibody In Autoimmune Pulmonary Alveolar Proteinosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2010. 181
Akagawa, K.S., Takasuka, N., and Tokunaga, T.: LPS response in macrophages: pre-translational suppression of tumor necrosis factor expression by LPS.
Cellular and molecular aspecs of endotoxin reactions.(ed. by A. Nowotony, J.J. Spitzer, E.J. Ziegler) 1990
Akagawa, K.S., Kamoshita, K., Tomita, T., Yasuda, T., and Tokunaga, T.:Regulatory mechanism of expression of LPS binding site(s) and signaling events by LPS in macrophages.
ENDOTOXIN (ed. by H. Friedman, T.W. Klein, M. Nakano and A. Nowotny) 1990
Tokunaga, T., and Akagawa, K.S. : Refractory response of mouse lung macrophages to LPS. In "Mononuclear Phagocytes.
Characteristics, Physiology, and Function" (R. van Furth. ed.) Martinus Nijhoff Publlishers. Bosston, Dordrecht. Lancester. 1985
Tokunaga, T., and Akagawa, K.S.: Appearance of a cell surface antigen associated with the differentiation of mouse macrophages.
In メSELF-DEFENCE MECHANISMS, ROLE OF MACROPHAGESモ (Mizuno, D, Cohn, Z.A., Takeya, K, and Ishida, N. ed) University of Tokyo Press, Elsevier Biomedical. 1982
