Rchr

J-GLOBAL ID：200901074259609269 Update date: Nov. 14, 2024

Izawa Takashi

イザワタカシ | Izawa Takashi

Affiliation and department：
Job title： Associate Professor
Homepage URL (2)： https://nrid.nii.ac.jp/ja/nrid/1000030380017/ , https://nrid.nii.ac.jp/en/nrid/1000030380017/

Research field (1)： Developmental dentistry

Research keywords (7)： Rare Disease , Rheumatoid Arthritis , coupling factor , osteoclast , Orthodontics , 骨免疫学 , Osteoimmunology

Research theme for competitive and other funds (28)：

2022 - 2026 Mechanism of epigenetic regulation about bone remodeling in the ortho gnathic congenital diseases
2022 - 2025 Filamin A mediated epithelial-mesenchymal transition during embryonic palate development
2022 - 2025 Analysis of dysregulated bone healing mechanisms via aryl hydrocarbon receptor by smoking and its regulation
2021 - 2024 Challenge to analyze the regulatory mechanism of palatal wound healing via dioxin receptor by smoking
2021 - 2022 Analysis of bone destruction mechanisms via RANKL and AhR signal crosstalk in osteoclasts

2018 - 2022 Epigenetic analysis of bone metabolism in rare diseases

2018 - 2022 Epigenetic analysis of new bone remodeling mechanism in the dentofacial region.

2017 - 2020 Analysis of epigenetic molecules in the osteoclast differentiation and treatment strategy for osteoporosis

2017 - 2020 Analysis of bone resorptive mechanism under osteoporosis via activated dioxin receptor by smoking

2018 - 2019 Analysis of bone metastatic tumor and bone destruction via insulin binding protein using in vivo imaging

2017 - 2019 Challenge to control the palatal scar formation and to analyze the regulatory mechanizm of metabolic reprogramming via hypoxia inducible genes

2018 - 2019 Bone and mineral regulatory mechanism in the osteoporosis and rheumatoid arthritis and its epigenetic analysis

2017 - 2018 Role of epigenetic molecules in osteoclast differentiation and treatment remedy for osteoporosis

2017 - 2018 Exploitation for diagnosis, treatment, and prevention method on osteoporosis with high risk for care targeting on epigenetic molecules

2018 - 2018 Treatment strategy for osteoporosis and the mechanism of bone metabolism and osteoclast differentiation by analyzing the epigenetic regulatory genes

2017 - 2018 Acceleration of wound healing and repression of wound scar formation by targeting about hypoxia inducible gene HIF1-α

2016 - 2017 Analysis of bone metabolism via signal crosstalk between AhR and RANKL

2016 - 2017 Analysis of bone metabolism by dioxin receptor AhR

2015 - 2017 Challenge to analyze the regulatory mechanism of bone metabolism by dioxin receptor AhR

2013 - 2016 Analysis of bone and cartilage destruction mechanism via RANKL/Fas signaling in rheumatoid arthritis

2008 - 2010 Functional analysis of periostin -anti-apoptotic action of periostin in osteoblasts and periodontal ligament cells

2008 - 2009 Molecular mechanism of TMJ-RA bone and cartilage destruction in the field of osteoimmunology

2008 - 2009 Regulation of bone and cartilage destruction via RANKL/Fassignaling crosstalk in temporomandibular joint.

2007 - 2009 Development of a novel zinc releasing cement by conversions of zinc phosphate into zinc calcium phosphate

2007 - 2008 Analysis of cytoskeieton regulation system by Rho family protein RhoE in periodontal ligament cells

2006 - 2008 Basic study for developing new therapies and its practical use for craniofacial anomalies

2006 - 2007 Analysis of bone destruction mechanism due to TMJ-RA via RANKL signaling

2005 - 2006 RNAi

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Papers (68)：

Kana Kono, Takashi Murakami, Saori Tanizaki, Noriaki Kawanabe, Atsuro Fujisawa, Masahiro Nakamura, Mitsuhiro Hoshijima, Takashi Izawa, Hiroshi Kamioka. Comprehensive clinical evaluation of indirect and direct bonding techniques in orthodontic treatment: a single-centre, open-label, quasi-randomized controlled clinical trial. European Journal of Orthodontics. 2024. 46. 6. cjae036
Janvier Habumugisha, Sumire Ida, Masahiro Nakamura, Kana Kono, Kenta Uchida, Takumi Moriya, Megumi Konko, Satoru Hayano, Takashi Izawa, Hiroshi Kamioka. Clinical Prediction Models for Upper Airway Volume Based on Soft Palate and Airway Lumen Dimensions in Adults With Varying Vertical Skeletal Patterns. International Dental Journal. 2024
Habumugisha J, Nakamura M, Kono K, Uchida K, Konko M, Izawa T, Kamioka H. Novel prediction models for pharyngeal-airway volume based on the cranial-base and midsagittal cross-sectional area of the airway in the pharyngeal region: a cephalometric and magnetic resonance imaging study. Orthodontics and Craniofacial Research. 2024. 27. 3. 394-402
中西泰之, 植田紘貴, 星島光博, 井澤俊, 上岡寛. NSAIDs系鎮痛薬の常用による歯の移動の遅延を認めた上下顎前突症例の一治験例. 日本矯正歯科学会大会プログラム・抄録集. 2022. 81回. 229-229
Islamy Rahma Hutami, Takashi Izawa, Tsendsuren Khurel-Ochir, Takuma Sakamaki, Akihiko Iwasa, Shuhei Tomita, Eiji Tanaka. HIF-1α controls palatal wound healing by regulating macrophage motility via S1P/S1P ₁ signaling axis. Oral Diseases. 2022. 28. 4. 1157-1169

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MISC (23)：

Yusaku Hamada, Takashi Izawa, Yuri Yoshikawa, Gohji Kozaki, Hiroshi Kamioka. Mechanisms of osteoclast differentiation and fracture healing mediated by IGFBP signaling. Journal of Japanese Society for Bone Morphometry. 2023. 33. 2. 48-49
Yuri Yoshikawa, Takashi Izawa, Yusaku Hamada, Gohji Kozaki, Yuki Namba, Hiroshi Kamioka. Analysis of osteoclast differentiation and bone healing mechanism via aryl hydrocarbon receptor. Journal of Japanese Society for Bone Morphometry. 2023. 33. 2. 46-47
Takashi Izawa. Crosstalk between RANKL and AhR signaling regulates TMJ-RA. 2023. 38. 68-73
井澤俊, 吉川友理, 浜田勇作, 上岡寛. 内分泌撹乱物質AhRリガンドB[a]PはCyp1a1シグナルを介して破骨細胞分化および骨代謝を制御する. 第41回日本骨形態計測学会記録集特別企画〜医用画像から新しい骨形態計測への橋渡しを担うAI〜. 2022. 78-79
IZAWA Takashi. Analysis of molecular mechanism about epigenetic gene related to osteoclast differentiation and treatment strategy for osteoporosis. Sumitomo electronic group. 2019. 15-20

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Lectures and oral presentations (86)：

内因性AhRリガンドKynurenineを介した破骨細胞分化機構の解明
(第83回日本矯正歯科学会学術大会 2024)
IGF結合蛋白シグナルとRANKLシグナルの相互作用による破骨細胞分化・活性および骨折治癒機構の解明
(第83回日本矯正歯科学会学術大会 2024)
Effect of human long noncoding RNA on osteoclast deifferentiation
(The 83rd Annual Meeting of the Japanese Orthodontic Society 2024)
Signaling crosstalk between IGFBP and IGF-I signaling axis regulate osteoclast differentiation.
(ASBMR 2024 annual meeting 2024)
AhR ligands regulates subchondral bone remodeling via osteoclast differentiation.
(Korean Division of the International Association for Dental Research (KADR-JADR Joint Symposium) 2024)

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Works (5)：

内分泌撹乱物質AhRリガンドであるB[a]PおよびFICZはAhR/Cyp1a1シグナル伝達経路を介して破骨細胞分化および骨代謝を制御する
日本骨代謝学会 first author記事吉川友理, 井澤俊, 上岡寛 2021 - 現在
The nuclear receptor AhR controls bone homeostasis by regulating osteoclast differentiation via the RANK/c-Fos signaling axis.
JSBMR, first author, Izawa Takashi 2017 -
Rebamipide Attenuates Mandibular Condylar Degeneration in a Murine Model of TMJ-OA by Mediating a Chondroprotective Effect and by Downregulating RANKL-mediated Osteoclastogenesis.
JSBMR, first author, Izawa Takashi
Smad3 Deficiency Leads to Mandibular Condyle Degradation via the Sphingosine 1-Phosphate (S1P)/S1P3 Signaling Axis.
JSBMR, first author, Izawa Takashi
ASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis.
JSBMR, first author, Izawa Takashi

Education (2)：

- 2004 The University of Tokushima
- 2000 The University of Tokushima Faculty of Dentistry School of Dentistry

Professional career (1)：

Ph.D. (The University of Tokushima)

Work history (6)：

2021/09 - 現在 Okayama University Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Associate Professor
2019/10 - 2021/08 Okayama University Hospital, Orthodontics lecturer
2015/04 - 2019/09 Tokushima University Graduate School, Institute of Biomedical Sciences Department of Orthodontics and Dentofacial Orthopedics Assistant Professor
2012/10 - 2015/03 University of Tokushima Graduate School, Institute for Health Bioscience Department of Orthodontics and Dentofacial Orthopedics Assistant Professor
2009/10 - 2012/09 Washington University in St. Louis, School of Medicine Department of Pathology and Immunology Postdoc Research Associate

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Committee career (12)：

2024/01 - 現在 Chu-Shikoku Orthodontic Society Sub President
2022/04 - 現在日本矯正歯科学会代議員
2022/01 - 現在 Chu-shikoku orthodontic society Council
2021/08 - 現在岡山歯学会評議員
2021/11 - 2022/03 令和3年度岡山大学未来懇談会参加メンバー

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Awards (35)：

2024/10 - Japanese Orthodontic Society Plenary presentation award
2023/07 - Japanese Society for Bone Morphometry Plenary award
2023/06 - Japanese Society for Bone Morphometry plenary young investigator ward
2023/05 - Japanese Stomatological Society rising scientist award
2023/02 - Plenary presentation award

2022/10 - JOS plenary investigator award

2022/10 - Japanese Orthodontic Society 81th JOS plenary poster award Analysis of osteoclast differentiation and bone healing via aryl hydrocarbon receptor.

2022/07 - Japanese Society for Bone Morphometry young investigator award

2021/11 - Japanese Orthodontic Society (JOS) Plenary poster award, the 80th annual meeting of JOS The AhR endogenous ligand FICZ regulates bone homeostasis by regulating osteoclast differentiation via AhR/Cyp1a1 signaling

2021/10 - Ryobi Memorial foundation Ryobi Memorial foundation

2021/07 - Japanese Society for Bone Morphometry young investigator award

2019/08 - Japanese Society for Bone and Mineral Research ASBMR 2019 Travel Award

2019/04 - Smoking Research Foundation Young Investigator Grant (Year 3)

2019/02 - ASCO, Assocation of Orthodontics (Singapore) Congress Poster competition research winner : HIF1 alpha regulates the palatal wound healing via M1/M2 macrophage reprogramming

2019/02 - Tokushima University and Taiho Pharmaceutical company basic research promotion Cancer related basic research Principal Investigator

2018/11 - Japanese Orthodontic Society The 77th JOS plenary poster award

2018/08 - Tokushima University Research Clusters of Tokushima University 2018 selected cluster research grant (Principal Investigator)

2018/07 - The Japanese Society for Bone and Mineral Research 2018 JSBMR Rising Stars Grant

2018/04 - Smoking Research Foundation Young Investigator Grant (Year 2)

2017/11 - Sumitomo electric group

2017/11 - Mitsui Sumitomo Insurance Welfare Foundation

2017/11 - The Mochida Memorial Foundation for Medical and Pharmaceutical Research

2017/11 - Takeda Science Foundation Takeda Science Foundation

2017/10 - Japanese Orthodontic Society 76th JOS plenary poster award (Academic exhibition)

2017/07 - Smoking Research Foundation Young Investigator Grant (Year 1/3)

2017/03 - The Nakatomi Foundation

2016/12 - SUZUKEN MEMORIAL FOUNDATION

2016/11 - Japanese Orthodontic Society The 75th JOS plenary poster award

2016/10 - The Ichiro Kanehara Foundation for the Promotion of Medical Science & Medical Care The Ichiro Kanehara Foundation for the Promotion of Medical Science & Medical Care

2016/08 - Tokushima University School of Dentistry 2016 Plenary Research Award of Tokushima University School of Dentistry

2015/11 - Japanese Orthodontic Society 74th JOS plenary poster award (corresponding author)

2014/10 - Japanese Orthodontic Society 73th JOS plenary poster award (corresponding author)

2009 - Japanese Orthodontic Society 68th JOS plenary poster award (corresponding author)

2008 - Japanese Orthodontic Society 67th JOS plenary poster award (first author, corresponding author)

2007/11 - American Society for Bone and Mineral Research ASBMR Young Investigator Travel Grant

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Association Membership(s) (16)：

Japanese Society for Bone Morphometry , Okayama Dental Society , 日本矯正歯科学会 , Shikoku Dental Research Association , JAPANESE STOMATOLOGICAL SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , JAPANESE ASSOCIATION FOR ORAL BIOLOGY , AMERICAN SOCIETY FOR BONE AND MINERAL RESEARCH , JAPANESE SOCIETY FOR BONE AND MINERAL RESEARCH , 日本口蓋裂学会 , 日本顎変形症学会 , 日本免疫学会 , 中・四国矯正歯科学会 , 日本顎関節学会 , Japanese Society for Immunology , Japanese Orthodontic Society

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