2017 - 2022 Functional analysis of genes responsible for neurological diseases using a method for introducing conditional mutations in a single generation
2018 - 2021 Mechanisms of cancer metabolism and drug resistance regulated by S1P in triple negative breast cancer
2017 - 2019 Development of a comprehensive tag-insertion method that enables dynamic in vivo analysis
2016 - 2019 Development of a new generation method of transgenic common marmoset, a potential resource for various researches
2016 - 2019 Clinical significance of sphingosine-1-phosphate and sphingosine kinase 1 in lymphatic spread of esophageal cancer
2016 - 2018 Physiological role of the 5HT1AR in the regulation of sleep/wakefulness states
2014 - 2017 Functional analysis of the role of hippocampal CA2 region in social behaviour and memory.
2014 - 2016 Development of applicable methods for one-step generation of genetically modified mammals specialized in brain function analysis
2012 - 2016 Development of new methods for a gene-manipulated rat for the analysis of human brain function
2012 - 2014 Functional analysis of the role of hippocampal CA2 region in memory by conditional targeting
2010 - 2012 Molecular pathogenesis of ALS: approach from TDP-43 function.
2009 - 2011 Glutamate receptor dynamism in the brain functions and diseases
2009 - 2010 Analysis of the molecular mechanism regulating synaptic functions in the mouse cerebellar cortex using a system for conditional knockout in the cells constituting synapses.
2007 - 2008 Development of systematic gene manipulating techniques for analysis of synaptic proteins on the C57BL/6 strain
2005 - 2007 Molecular mechanism of the synaptic targeting and activity regulation of glutamate receptors
2003 - 2004 遺伝子組換え法を用いた神経回路形成・調節機序の分子解析
2001 - 2003 Molecular analysis of higher brain functions using conditional gene targeting
2001 - 2002 神経回路の形成、維持、変化における細胞接着分子の役割
2001 - 2001 時間空間特異的な遺伝子発現制御系を用いた記憶・学習の分子機構の解明
1998 - 2000 コンディショナルジーンターゲティングを用いたシナプス結合形成の分子機構解析
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Papers (167)：
Hiroaki Taketsuru, Runa Hirayama, Ena Nakatsukasa, Rie Natsume, Keizo Takao, Manabu Abe, Kenji Sakimura. Generation of rat offspring from ovarian oocytes by xenotransplantation. Scientific reports. 2024. 14. 1. 20109-20109
Yung Ting Hsiao, Yohko Yoshida, Shujiro Okuda, Manabu Abe, Seiya Mizuno, Satoru Takahashi, Hironori Nakagami, Ryuichi Morishita, Kenya Kamimura, Shuji Terai, et al. PCPE-1, a brown adipose tissue-derived cytokine, promotes obesity-induced liver fibrosis. The EMBO journal. 2024
Hisako Nakayama, Taisuke Miyazaki, Manabu Abe, Maya Yamazaki, Yoshinobu Kawamura, Myeongjeong Choo, Kohtarou Konno, Shinya Kawata, Naofumi Uesaka, Kouichi Hashimoto, et al. Direct and indirect pathways for heterosynaptic interaction underlying developmental synapse elimination in the mouse cerebellum. Communications biology. 2024. 7. 1. 806-806
Izumi Iida, Kohtarou Konno, Rie Natsume, Manabu Abe, Masahiko Watanabe, Kenji Sakimura, Miho Terunuma. Behavioral analysis of kainate receptor KO mice and the role of GluK3 subunit in anxiety. Scientific reports. 2024. 14. 1. 4521-4521
