2015 - 2018 Functional roles of the cancer stem cell marker EpCAM in cancer bone metastasis
2015 - 2018 Functional roles of RhoT1 on repair of periodontal tissue
2013 - 2016 Development of alveolar bone turnover control method based on Wnt5a
2012 - 2015 Regulations of bone metabolism by bovine- and neutrophil-derived lactoferrin
2012 - 2015 Functional analysis of Osterix in immature odontoblasts for cell differentiation
2011 - 2013 The mechanisms of bone-selective cancer metastases based on the pre-metastatic bone niche hypothesis
2010 - 2012 Development of a novel bone induction method for dental implant based on the mechanism of fracture healing
2009 - 2012 Roles of cancer stem cells in the development and progression of cancer metastasis to bone
2009 - 2011 Analysis of roles of Wnt5a in alveolar bone remodeling, and their application for orthodontic tooth movement.
2008 - 2010 Microenvironment of stem cells in bone formation
2008 - 2009 造血幹細胞ニッチを介した癌の骨転移成立機構の解明
2005 - 2009 Cross talk between bone microenvironment and metastatic cancer cell
2006 - 2007 Roles of Hypoxia and the Trantscription Factor Hypoxia-Inducible Factor-lalpha(HIF-lalpha) in the Development and Progression of Bone Metastases of Breast Cancer
2005 - 2007 Investigation of molecular mechanisms of Sox9 transcriptional factory during enchandral ossification
2003 - 2006 Investigation of relationship between Osterix and Cbfal during BMP2-induced osteoblast differentiation
2004 - 2005 乳癌の骨転移におけるシクロオキシゲナーゼ-2の関与
2000 - 2004 c-Srcリン酸化を介する転写因子NF-κBの活性化と骨吸収の制御
2002 - 2003 乳癌の骨転移におけるカドヘリン-11の関与
2001 - 2002 破骨細胞の骨吸収エネルギー産生におけるナトリウム依存性リン輸送体の役割
2001 - 2002 Regulation of Cbfa1 and IHH expression by retinoid signaling during encondral ossification
2000 - 2002 The Regulation of osteobiastogenesis and adipogenesis by BMP2
2000 - 2001 癌の骨転移におけるIGF-1細胞内シグナルの関与
癌の骨転移に関する分子細胞生物学的研究
Study on Molecular and Cellular Mechanism of Bone Metastasis
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Papers (69)：
Toru Hiraga, Daisuke Nishida, Kanji Horibe. Primary tumor-induced immunity suppresses bone metastases of breast cancer in syngeneic immunocompetent mouse models. Bone. 2024. 178. 116944-116944
Toru Hiraga, Kanji Horibe, Masanori Koide, Teruhito Yamashita, Yasuhiro Kobayashi. Sclerostin blockade promotes bone metastases of Wnt-responsive breast cancer cells. Cancer science. 2023. 114. 6. 2460-2470
何 治鋒, 溝口 利英, 平賀 徹, 中道 裕子, 山下 照仁, 小出 雅則, 宇田川 信之, 小林 泰浩. マクロファージはLepR陽性細胞を活性化し骨再生を促進する(Macrophages promote bone regeneration through the activation of LepR(+) cells). Journal of Oral Biosciences Supplement. 2022. 2022. 166-166
Ayako Yokoyama, Tomoka Hasegawa, Toru Hiraga, Tamaki Yamada, Yimin, Hiromi Hongo, Tomomaya Yamamoto, Miki Abe, Taiji Yoshida, Yasuo Imanishi, et al. Altered immunolocalization of FGF23 in murine femora metastasized with human breast carcinoma MDA-MB-231 cells. Journal of Bone and Mineral Metabolism. 2021. 39. 5. 810-823
Toru Hiraga, Susumu Ito, Toshihide Mizoguchi. Opposing Effects of Granulocyte Colony-Stimulating Factor on the Initiation and Progression of Breast Cancer Bone Metastases. Molecular cancer research : MCR. 2021
何治鋒, 平賀徹, 石莉楠, 李若萱, 中道裕子, 中道裕子, 山下照仁, 山下照仁, 小出雅則, 小出雅則, et al. Macrophages promote bone regeneration through the activation of LepR(+)cells. 松本歯学. 2021. 47. 2
Toru Hiraga, Hiroaki Nakamura. Functional Comparison between CD44s and CD44v8-10 in Cancer Metastasis to Bone. JOURNAL OF BONE AND MINERAL RESEARCH. 2017. 32. S312-S312
Bone metastases-morphology.
Cancer and the skeleton 2000
Bone metastases-morphology.
Cancer and the skeleton 2000
Professional career (1)：
Ph.D. (Niigata University)
Work history (2)：
1997 - 1999 Research Fellow, University of Texas Health Science Center at San Antonio
1997 - 1999 Japan Society for the Promotion of Science, Research Fellow
Association Membership(s) (9)：
JAPANESE ASSOCIATION FOR ORAL BIOLOGY
, 日本癌学会
, 日本骨代謝学会
, 米国癌学会(American Association for Cancer Research)
, 米国骨代謝学会(American Society for Bone and Mineral Research)
, Japanese Society for Bone and Mineral Research
, Japanese Cancer Association
, American Society for Bone and Mineral Research
, American Association for Cancer Research
