MASAHIKO KURABAYASHI

2017 - 2020 Clarification of molecular mechanisms and establishment of appropriate therapies for atypical inherited arrhythmia syndromes

2016 - 2019 Temporal spatial analysis and physiological significance of ATP variability in myocardial infarction by ATP-visualized mice

2016 - 2019 Regulation of vascular smooth muscle cell differentiation by fatty acid composition

2015 - 2018 Analysis for alteration of fatty acid fraction in COPD and idiopathic pulmonary fibrosis

2015 - 2018 The role of PIAS1/SUMO1 on pulmonary hypertension

2016 - 2018 Mechanism of pulmonary fibrosis induced by deranged fatty acid composition

2014 - 2017 A energy shift from fatty acid to glucose is detrimental to pressure-overloaded heart

2014 - 2017 An examination of mutation-specific precipitation factors for ventricular tachyarrhythmias in concealed inherited arrhythmia syndromes

2014 - 2017 Study on Machine Learning of Health Big Data Based on Cloud Computing

2013 - 2016 Pathophysiological significance of fatty acid composition and catalytic enzyme in pulmonary diseases.

2013 - 2016 Cell Type-specific Role of TGFb Signaling in Cardiac Remodeling and Myocardial Energy Metabolism

2012 - 2015 The role of Notch1-TGFbeta-PIAS1 on pulmonary hypertension

2012 - 2015 Molecular mechanisms of the association between .t2DM and Tskotudo

2011 - 2013 Genetic background of ventricular tachyarrhythmias associated with acute myocardial ischemia

2011 - 2013 駆出率保持性心不全発症をもたらす心血管系因子の解明と治療法への応用

2011 - 2013 Exploration of the optimal biomarkers reflecting each stage of atherosclerotic progression in patients with diabetes mellitus

2011 - 2013 Cluster Analysis of Characteristics in the Nature of Personal Health with Healthcare-Data-Mining

2012 - 2012 脳エネルギー代謝と行動の制御における毛細血管内皮細胞PPARガンマの役割の解明

2010 - 2012 Role of interstitial sodium accumulation on inflammatory cytokines and lymphcapillary reconstruction in salt-sensitive hypertension.

2008 - 2010 Investigation of molecular mechanism in the development of chronic obstructive pulmonary disease using klotho mutant mice.

2008 - 2010 NOTCH-FABP PATHWAY REGULATES TRANS-ENDOTHELIAL FATTY ACID TRANSPORT IN HEART

2008 - 2010 Study on Development of Support System for Healthcare Against Metabolic-Syndrome

2008 - 2010 Molecular mechanism of vascular calcification in chronic kidney disease

2007 - 2008 Clarification of molecular mechanism regulating differentiation of peripheral blood mononuclear cell into vascular smooth muscle cell and development of new strategy for clinical application

2007 - 2007 結合組織増殖因子による心臓線維化・拡張不全発症機序の解明と診断法、治療法の開発

2006 - 2007 Investigation of molecular mechanism in the development of pulmonary emphysema and susceptibility to cigarette smoke-induced lung injury using transgenic animal models

2006 - 2007 Clarification of vascular smooth muscle cell differentiation by Notch signaling

2006 - 2007 Mechanisms of cardiac dysfunction in metabolic syndrome

2006 - 2007 Molecular Mechanism of Vascular Calcification

2005 - 2006 Role of Angiotension and CD36 Expression in Multiple Risk Factors for Atherosclerosis

2005 - 2006 Establishment of novel therapeutic strategy for heart failure by modulating the function of cardiac contractile and relaxation proteins

2005 - 2006 動脈硬化におけるNotch-HERP経路の役割の解明と新規治療法の開発

2004 - 2005 Investigation of molecular mechanism in the development of chronic obstructive pulmonary disease (COPD) and susceptibility to cigarette smoke-induced lung injury using transgenic animal models.

2004 - 2005 Mechanisms of leptin receptor isoforms expression in heart diseases

2004 - 2005 Molecular Mechanisms of Vasa Vasorum Angiogenesis and Dysregulation of Vascular Smooth Muscle Cell Differentiation

2003 - 2004 血管内皮細胞におけるTNFα関連アポトーシス誘導因子TRALの機能の解明

2003 - 2004 Analysis of Inducers of Transformation From Monocytes to Macrophages and Their Application for vascular Protection Therapy

2003 - 2004 Development of novel therapeutic strategy for heart failure by improving Ca2+ transport function of sarcoplasmic reticulum

2002 - 2003 Hereditary Abnormalities of Multiple Risk Factors for Atherosclerosis ; Role of Endothelial Dysfunction and Aortic CD36 Expression in Diabetic Hyperlipidemic Rats

2002 - 2003 Regulation of the tumor necrosis factor-α promoter in the development of heart failure

2002 - 2003 Investigation of molecular mechanism in the development of chronic obstructive pulmonary disease (COPD) using transgenic animal models.

2002 - 2003 Functional Analysis of p53-Regulatory Protein CARP in Atherosclerosis

2001 - 2003 転写因子レベルでの血管狭窄病変の機序解明と遺伝子導入によるその治療戦略

2001 - 2002 マクロファージにおけるPPARγを介する動脈硬化関連遺伝子の発現抑制機構の解明

2001 - 2002 Development of novel heart failure therapy by using gene transfer into cardiac myocytes

2001 - 2002 Investigation of molecular mechanism in the development of lung and pulmonary emphysema in the aging mouse model "klotho" .

2000 - 2001 SUPPRESSION OF TUMOR GROWTH BY ANTIANGIOGENIC AGENT AND INDUCTION TO TUMOR DORMANCY IN BREAST CANCER

1999 - 2001 The role of Klotho in allograft vascular disease

2000 - 2000 血管壁細胞における代血管特異的因子CARPの機能解析

1999 - 2000 Transcriptional regulation of the SERCA2 gene during the development of heart failure

1999 - 2000 Klotho gene product may have a role to regulate VEGF and p21 and tightly linked to the endothelial function to release NO

1999 - 2000 Transcriptional Regulation of the cardiovaocular genes in respone to stress

1999 - 1999 成体における血管前駆細胞の固定と血管病態での役割の検討

1998 - 1999 Klotho欠損マウスにおける心筋細胞の分化異常に関する研究

1998 - 1999 転写因子による血管新生とその抑制の分子機構の解明

1997 - 1998 Molecular Mechanisms of Genetic Response of Myocardial Cells to Cytotoxic Stress

1997 - 1998 Physiological function of ageing suppression gene klotho and its role in development of adult disease

1997 - 1998 Molecular mechanisms of vascular aging : analysis of a newly developed aging mouse

1997 - 1997 血管平滑筋細胞における転写因子Idの機能と発現調節機序

1996 - 1997 Development of Strategy of Molecular Cloning of Cardiac-Specific-Gene by use of Adriamycin

1987 - 1989 Molecular analysis of the pathophysiology of heart disease