Hashii Minako

ハシイミナコ | Hashii Minako

Affiliation and department：

Research field (2)： Clinical pharmacy , Physiology

Research keywords (7)： intracellular Ca(2+) signaling , CD38 , cADPリボース , ラスがん遺伝子 , Ras , CD38 , cyclic ADP-ribose

Research theme for competitive and other funds (8)：

2010 - 2012 Activation mechanism of cyclic ADP-ribose-synthesizing enzyme CD38
2010 - 2012 Study on some proteins controling cell death in oxidative stress-induced neuronal cell death.
2007 - 2009 Neurochemical studies on molecules involved in social recognition and research on genes and therapy in autism.
2007 - 2008 Sensor mechanism of extracellular cyclic ADP-ribose
2004 - 2006 ラット新生仔脳及びCD38ノックアウトマウス脳のADPリボシルシクラーゼの精製

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Papers (61)：

Haruhiro Higashida, Minako Hashii, Yukie Tanaka, Shigeru Matsukawa, Yoshihiro Higuchi, Ryosuke Gabata, Makoto Tsubomoto, Noriko Seishima, Mitsuyo Teramachi, Taiki Kamijima, et al. CD38, CD157, and RAGE as Molecular Determinants for Social Behavior. Cells. 2019. 9. 1
Hashii, Minako, Tanaka, Yukie, Higuchi, Yoshihiro, Gabata, Ryosuke, Tsubomoto, Makoto, Iwatsuka, Noriko, Teramachi, Mitsuyo, Kamijima, Taiki, Yokoyama, Shigeru, Matsukawa, Shigeru, et al. A Ca2+-Calmodulin-Dependent Protein Kinase II Inhibitor Suppresses Cell Migration of CD38-Expressing Human Embryonic Kidney Cells: A Preliminary Report. 2018. 6. 4. 85-88
Tsuji, Takahiro, Liang, Mingkun, Lopatina, Olga, Yuhi, Teruko, Tsuji, Chiharu, Zhong, Jing, Akther, Shirin, Nishimura, Tomoko, Amina, Sarwat, Liu, Hong-Xiang, et al. TRPM2, a New Player, in Cyclic ADP-Ribose/CD38-Dependent Oxytocin Release in the Hypothalamus. 2018. 6. 5. 71-75
Jing Zhong, Sarwat Amina, Mingkun Liang, Shirin Akther, Teruko Yuhi, Tomoko Nishimura, Chiharu Tsuji, Takahiro Tsuji, Hong-Xiang Liu, Minako Hashii, et al. Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice. FRONTIERS IN NEUROSCIENCE. 2016. 10
Zhong J, Amina S, Liang M, Akther S, Yuhi T, Nishimura T, Tsuji C, Tsuji T, Liu HX, Hashii M, et al. Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice. Frontiers in neuroscience. 2016. 10. 304

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MISC (25)：

Yoshihiro Higuchi, Keiko Takaki, Ayako Furukawa, Minako Hashii, Nobuaki Shimizu. TiO2 particles induce apoptosis associated with chromosomal giant DNA fragmentation and caspase-3 activation in L1210 leukemia cells. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 220P-220P
Minako Hashii, Sarwat Amina, Olga Lopatina, Haruhiro Higashida. Role of human CD38/ADP ribosyl cyclase for cell migration. NEUROSCIENCE RESEARCH. 2010. 68. E135-E135
Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-ribose or Ca(2+) concentrations is involved in autoregulation of oxytocin secretionin the hypothalamus and posterior pituitary in male mice. 2009
Yoshihiro Higuchi, Minako Hashii, Hideii Tanii, Yuji Mizukami. Arachidonic acid promotes glutamate-induced cell death associated with necrosis by 12-lipoxygenase activation in glioma cells. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2008. 106. 254P-254P
H Higashida, S Kamiyama, JS Zhang, D Jin, M Hashii, N Sugimoto, N Shimizu. Pre- and post-synaptic roles of cyclic ADP-ribose in dopaminergic neurotransmission in rodent Caudate Putamen (1). JOURNAL OF PHARMACOLOGICAL SCIENCES. 2004. 94. 287P-287P

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Works (2)：

CD38活性化機構の解析
2007 -
activation mechanism of CD38
2007 -

Education (4)：

- 1987 Kanazawa University
- 1987 Kanazawa University Graduate School, Division of Medicine Neurology
- 1983 Kanazawa University
- 1983 Kanazawa University Kanazawa University School of Medicine

Professional career (1)：

医学博士 (金沢大学)

Work history (3)：

1995 - -: 金沢大学講師
1995 - -: Kanazawa University
Kanazawa University Institute of Medical,Pharmaceutical and Health Sciences, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine

Committee career (3)：

2002 - -: 日本神経化学会評議員
2002 - -: Japanese Society for Neurochemistry
2002 - 日本神経化学会評議員

Awards (3)：

2014 - 日本学術振興会科学研究費審査委員表彰
1994 - 内藤記念科学振興財団第26回内藤記念科学振興財団研究助成 rasトランスフォ-ム細胞などの培養細胞における、レセプタ-作動性Ca流入の電気生理学的解析
1993 - 日本女医会第14回日本女医会学術研究助成セカンドメッセンジャーレベルからみたてんかん原性の研究

Association Membership(s) (7)：

Sigma Xi , The New York Academy of Sciences , Society for Neuroscience , 日本内科学会 , 日本神経学会 , 日本生化学会 , 日本神経化学会

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