Ohta Tomohiko

オオタトモヒコ | Ohta Tomohiko

Affiliation and department：
Homepage URL (1)： http://www.marianna-u.ac.jp/t-oncology/

Research field (3)： General surgery, pediatric surgery , Cell biology , Molecular biology

Research keywords (5)：ユビキチン , DNA修復 , BRCA1 , 乳癌 , 腫瘍学

Research theme for competitive and other funds (24)：

2023 - 2026 乳がんのDNA損傷修復とcGAS-STING経路を制御するシグナル伝達系の解析
2020 - 2023 乳がんにおける内分泌療法耐性獲得メカニズムの解析
2018 - 2020 高リスクER陽性乳がんの内分泌療法耐性機序解明に基づく診断法と薬物療法の開発
2017 - 2020 乳癌・卵巣癌治療の分子基盤としてのグアニン4重鎖解除機構の解析
2016 - 2018 A study of mechanism underlying carcinogenesis promoted by estrogen receptor in BRCA1 deficient cells

2014 - 2017 難治性乳癌のER非依存性病態の解明に基づく新規治療法の開発基盤研究

2014 - 2017 Functional analysis of BRCA1 as the molecular basis of breast cancer therapy

2012 - 2017 Regulation of DNA repair machinery by K6- and K63-linked polyubiquitin chains

2014 - 2016 Unravelling the mechanism of ovarian carcinogenesis caused by BRCA1 depletion and estrogen action

2012 - 2014 難治性乳癌の克服に向けた画期的治療法の開発基盤推進研究

2011 - 2014 Research on the breast cancer chemotherapy targeting synthetic lethality caused by the factors in the DNA damage repair pathways.

2011 - 2012 DNA相同組替え修復機構におけるBRCA1ユビキチンリガーゼ活性の役割

2009 - 2011 BRCA1ユビキチンリガーゼによるDNA損傷応答

2008 - 2011 Analyses of DNA damage response to neoadjuvant chemotherapy in basal-like breast cancer

2008 - 2010 HERC2によるS期およびG2/M期チェックポイント制御機構の解析

2007 - 2009 BRCA1ユビキチンリガーゼによる乳癌抑制機構の解析

2006 - 2008 Study of DNA repair mechanisms that affect chemosensitivity of breast cancer

2004 - 2006 Mechanisms that regulate chromosomal stability through the ubiquitin lipase activity of BRCA1

2004 - 2006 細胞周期におけるBRCA1-BARD1ユビキチンリガーゼ活性の調節機構

2002 - 2004 ユビキチンリガーゼBRCA1-BARD1によるDNA修復および転写の制御

2001 - 2002 BRCA1-BARD1ヘテロダイマーユビキチンリガーゼによる細胞周期制御

2000 - 2002 Elucidation of substrates and analysis of the function of BRCA 1 ubiquitin ligase

1996 - 1997 静止期癌細胞の細胞周期導入時においてG1/Sに先行する未知のG0/G1 event

1995 - 1996 癌細胞におけるLRP蛋白細胞外ドメインの糖鎖形成不全と細胞増殖抑制との関係

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Papers (70)：

Nakagawa S, *Miyashita M, Maeda I, Goda A, Tada H, Amari M, Kojima Y, Tsugawa K, Ohi Y, Sagara Y, et al. Potential role of Fbxo22 in resistance to endocrine therapy in breast cancer with invasive lobular carcinoma. Breast Cancer Res Treat. 2024. 204. 453-463
Nihira NT, Ohta T, *Liu Z, *Dai X. Editorial: Community series in post-translational modifications of proteins in cancer immunity and immunotherapy, volume II. Front. Immunol. 2023. 14. 1289016
Mori T, Okamoto Y, Mu A, Ide Y, Yoshimura A, Senda N, Kawata YI, Kawashima M, Kitao H, Tokunaga E, et al. Lack of impact of the ALDH2 rs671 variant on breast cancer development in Japanese BRCA1/2-mutation carriers. Cancer Med. 2022. 12. 6. 6594-6602
Zhu J, Wu W, Togashi Y, Nihira NT, Johmura Y, Zhu D, Nakanishi M, Miyoshi Y, *Ohta T. Alteration of Trop-2 expression in breast cancer cells by clinically used therapeutic agents and acquired tamoxifen resistance. Breast Cancer. 2022. 29. 1076-1087
Tencer AH, Liu J, Zhu J, Burkholder NT, Zhang Y, Wu W, Strahl BD, Ohta T, *Kutateladze TG. The ZZ domain of HERC2 is a receptor of arginylated substrates. Sci Rep. 2022. 12. 6063

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MISC (31)：

太田智彦. 遺伝性乳癌に対する遺伝子修復不全標的治療. 乳癌診療 state of the art - 科学に基づく最新診療. 2022. 26-30
Ohta T, Wu W. Molecular Basis of BRCA1 and BRCA2: Homologous Recombination Deficiency and Tissue-Specific Carcinogenesis. Hereditary Breast and Ovarian Cancer(著書). 2021. 15-29
Mingzhang Zhu, Wenwen Wu, Tomohiko Ohta. Failure of homologous recombination DNA repair as a target for cancer therapy. Journal of Molecular Targeted Therapy for Cancer. 2019. 17. 1. 69-76
Mingzhang Zhu, Tomohiko Ohta. Ubiquitin and homologous recombination DNA repair. Medical Science Digest. 2019. 45. 4. 29-32
頼勇強, 太田智彦. 臨床医のための乳腺基礎医学「乳癌におけるDNA損傷と修復不全」. CANCER BOARD of the BREAST. 2018. 4. 1. 20-24

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Education (1)：

1985 - St.Marianna University School of Medicine Faculty of Medicine Depertment of Medicine

Work history (14)：

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Committee career (11)：

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Awards (3)：

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