Rchr
J-GLOBAL ID:200901075444717708   Update date: Nov. 05, 2024

Yokokawa Ryuji

ヨコカワ リュウジ | Yokokawa Ryuji
Affiliation and department:
Homepage URL  (2): https://www.mbsys.me.kyoto-u.ac.jp/https://www.mbsys.me.kyoto-u.ac.jp/en/
Research field  (5): Mechanics and mechatronics ,  Robotics and intelligent systems ,  Nanobioscience ,  Nano/micro-systems ,  Nanomaterials
Research keywords  (12): Microphysiological Systems (MPS) ,  マイクロ・ナノデバイス ,  On-chip vascular network ,  Microfluidic device ,  hiPSCs ,  モータタンパク質 ,  Organoid ,  細胞・組織 ,  自己組織化 ,  生体機能利用 ,  Micro Total Analysis Systems (MicroTAS) ,  BioMEMS
Research theme for competitive and other funds  (38):
  • 2024 - 2027 オンチップ血管網のリモデリングと安定化の理解による培養長期化と組織培養への応用
  • 2021 - 2027 仮想人体モデルを活用した感染症創薬モダリティの洗練と創成
  • 2022 - 2025 DEVELOPMENT AND EVALUATION OF A PERFUSABLE VASCULARIZED IVER SPHEROID MODEL
  • 2022 - 2025 High functionality of kidney microphysiological sytems(MPS) using human iPSCs and its application to disease models
  • 2022 - 2025 マイクロ流体デバイスを用いた脳卒中チップの作製と患者由来組織を用いた検証
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Papers (193):
  • Cheng Ma, Ramin Banan Sadeghian, Ryosuke Negoro, Kazuya Fujimoto, Toshikazu Araoka, Naoki Ishiguro, Minoru Takasato, Ryuji Yokokawa. Efficient proximal tubule-on-chip model from hiPSC-derived kidney organoids for functional analysis of renal transporters. iScience. 2024
  • Surachada Chuaychob, Ruyin Lyu, Miwa Tanaka, Ayumi Haginiwa, Atsuya Kitada, Takuro Nakamura, Ryuji Yokokawa. Mimicking angiogenic microenvironment of alveolar soft-part sarcoma in a microfluidic coculture vasculature chip. Proceedings of the National Academy of Sciences. 2024
  • Maneesha Shaji, Atsushi Tamada, Kazuya Fujimoto, Keiko Muguruma, Stanislav L Karsten, Ryuji Yokokawa. Deciphering potential vascularization factors of on-chip co-cultured hiPSC-derived cerebral organoids. Lab on a chip. 2024
  • Kazuya Fujimoto, Yoshikazu Kameda, Yuta Nagano, Sayaka Deguchi, Takuya Yamamoto, Rafal P Krol, Peter Gee, Yasufumi Matsumura, Toru Okamoto, Miki Nagao, et al. SARS-CoV-2-induced disruption of a vascular bed in a microphysiological system caused by type-I interferon from bronchial organoids. Lab on a chip. 2024
  • Yuji Takata, Ramin Banan Sadeghian, Kazuya Fujimoto, Ryuji Yokokawa. Online monitoring of epithelial barrier kinetics and cell detachment during cisplatin-induced toxicity of renal proximal tubule cells. The Analyst. 2024. 149. 13. 3596-3606
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MISC (121):
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Patents (12):
  • 近位尿細管生体模倣システム
  • マイクロ流体デバイス
  • 生体模倣システム
  • 生体模倣システム
  • マイクロ流体デバイス、及びマイクロ流体デバイスの使用法
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Books (1):
  • Technology and Development Trends of Organ(s)-on-a-Chip
    CMC Publishing Co., LTD. 2018
Lectures and oral presentations  (531):
  • 三次元血管網技術を基盤とするMicrophysiological systems (MPS)の開発
    (第40回日本DDS学会 2024)
  • Parallel Cultivation and Evaluation of Multiple Vascularized Tumor Spheroids Using a Microfluidic Device.
    (3rd Microphysiological Systems Wold Summit 2024)
  • hiPSC-derived Human Airway and Alveolus On-chip Models: Decoding Dynamic Immune Response to SARS-CoV-2 in Lungs.
    (3rd Microphysiological Systems Wold Summit 2024)
  • マイクロ流体デバイスを用いた生体模倣システム (Microphysiological system (MPS)) の開発
    (第43回日本アンドロロジー学会 2024)
  • A 2D Blood-Brain Barrier (BBB) model with iPSC-derived endothelial cells for DENV infection mechanisms evaluation.
    (化学とマイクロナノシステム学会第49回研究会 2024)
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Education (4):
  • 2002 - 2005 The University of Tokyo Department of Electrical Engineering Department of Electrical Engineering
  • 2000 - 2002 Kyoto University Graduate School of Engineering Department of Mechanical Engineering
  • 2000 - 2001 University of California, Los Angeles Department of Aerospace and Mechanical Engineering
  • 1996 - 2000 Kyoto University Faculty of Engineering Undergraduate School of Engineering Science
Professional career (1):
  • Ph.D. (The University of Tokyo)
Work history (10):
  • 2019/09 - 現在 Kyoto University Graduate School of Engineering Department of Micro Engineering Professor
  • 2011/11 - 2019/08 Kyoto University Graduate School of Engineering Department of Micro Engineering Associate Professor
  • 2018/04/01 - RIKEN Center for Biosystems Dynamics Research (BDR) Visiting Researcher
  • 2017/08/01 - Center for Developmental Biology, Riken Visiting Researcher
  • 2008/10 - 2014/03 Japan Science and Technology Agency (JST) Precursory Research for Embryonic Science and Technology (PRESTO) Researcher
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Committee career (54):
  • 2021/04 - 現在 日本学術振興会 産学協力委員会R031ハイブリッド量子ナノ技術委員会 バイオ分野委員
  • 2018/06 - 現在 科学技術振興機構(JST) 戦略的創造研究推進事業(CREST)「ゲノムスケールのDNA設計・合成による細胞制御技術の創出」領域アドバイザー
  • 2021/06 - 2022/03 日本医療研究開発機構(AMED) 課題評価委員
  • 2018/07/01 - 2020/03/31 The Institute of Electrical Engineers of Japan (IEEJ) -
  • 2018/04/01 - 2020/03/31 The Institute of Electrical Engineers of Japan (IEEJ) -
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Awards (32):
  • 2022/12 - 日本分子生物学会 MBSJ Science Pitch Award Deciphering the early angiogenic factors for in vitro vascularization of hiPSC-derived brain organoids
  • 2022/11 - 電気学会 センサ・マイクロマシン部門 第39回「センサ・マイクロマシンと応用システム」シンポジウム 奨励賞 気管支オルガノイドへのSARS-CoV-2感染が血管内皮細胞に引き起こすアクチンフィラメントの配向性変化
  • 2022/11 - 電気学会 センサ・マイクロマシン部門 第39回「センサ・マイクロマシンと応用システム」シンポジウム 優秀ポスター賞 Flow-induced Ca2+ signaling in proximal tubule cells extracted from kidney organoids on a microphysiological system
  • 2022/11 - 化学とマイクロ・ナノシステム学会 化学とマイクロ・ナノシステム学会第46回研究会(CHEMINAS46) 優秀発表賞 マイクロ流体デバイスを用いた胞巣状軟部肉腫と転座型腎細胞がんの血管新生誘導能の比較
  • 2022/11 - Future Technologies Future Technologiesフォトコンテスト 最多得票賞 院生の朝
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Association Membership(s) (5):
The Institute of Electrical Engineers of Japan ,  The Society for Chemistry and Micro-Nano Systems ,  The Japan Society of Mechanical Engineers ,  The Institute of Electrical and Electronics Engineers (IEEE) ,  Biophysical Society
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