Onodera Osamu

2016 - 2019 Strategies for overcoming vascular dementia focusing on dynamic functions of cerebral small vessels.

2015 - 2019 Brain Protein Aging and Dementia Control(International Research Activities Supporting Program)

2014 - 2019 Mechanism of protein aging from the point of turbulence of nucleic acid metabolism or its exclusion mechanism.

2017 - 2019 TGF-βシグナルを標的にしたCARASILの新規治療シーズの探索

2017 - 2019 ゲノム編集を用いた優性遺伝性中枢神経疾患の治療方法の開発

2017 - 2019 ポリグルタミン病に対する蛋白質凝集阻害薬の開発(大阪大学B-49)

2016 - 2018 重合体形成阻害を標的としたポリグルタミン病の新規治療法開発

2016 - 2018 Elucidation of the significance of MAPT polymorphism associated with sporadic tauopathies by using genome editing method.

2015 - 2018 Crosstalk between stress granules and autophagy in protein degradation

2014 - 2017 Amyotrophic Lateral Sclerosis and TDP-43: Elucidation of molecular neuropathology in terms of spread from its beginning

2016 - 2017 成人発症白質脳症の医療基盤に関する調査研究班

2014 - 2016 Heterogeneity of TDP-43 pathology and clinicopathologic correlations in sporadic amyotrophic lateral sclerosis

2013 - 2016 Establishment of TDP-43 C-terminal deficient mice using zinc finger nuclease and application to the model for amyotrophic lateral sclerosis

2013 - 2016 Approach to cerebral small vessel disease: lesson from CARASIL.

2013 - 2016 Identification of splicing factors that bind to expanded GGGGCC repeat and TDP-43 mRNA

2013 - 2016 Autoreguation of TDP-43 in ALS

2013 - 2016 Developing new therapeutic drugs that inhibit oligomer formation of polyglutamine disease proteins based on the hypothesis of oligomer toxicity in polyglutamine diseases

2013 - 2015 U12依存性スプライシングとALSサーキットパソロジー

2015 - 2015 新規臨床評価方法によるフォールディング病の化学シャペロンでの病態抑制効果の検討

2011 - 2014 ALS and TDP-43: Dose the splicing failure underlie the pathogenesis of ALS?

2013 - 2013 遺伝性脳小血管病およびその類縁疾患の診断基準の確立と治療法の研究

2012 - 2013 遺伝性脳小血管病およびその類縁疾患の診断基準の確立と治療法の研究

2010 - 2013 Molecular pathogenesis of cerebral small vessel disease.

2011 - 2012 細胞内膜構造に注目した運動神経病の画期的な治療法の開発

2011 - 2012 An immunohistochemical study on nuclear bodies in neurodegenerativediseases with abnormal protein aggregates

2010 - 2012 細胞内膜構造に注目した運動神経病の画期的な治療法の開発

2010 - 2012 Mathematic statistical analyses of relationship between severity of neurological symptom and MRI measurements of white matter injury

2010 - 2012 Molecular pathogenesis of ALS: approach from TDP-43 function.

2010 - 2012 Analysis of TDP-43 functions and modeling for ALS using conditional knockout mice

2011 - 2011 遺伝性脳小血管病の病態機序の解明と治療法の開発

2010 - 2011 遺伝性脳小血管病の病態機序の解明と治療法の開発

2010 - 2011 Identification for serum biomarker for ALS associated with the function of TDP-43

2010 - 2011 天然変性タンパク質の機能解析によるALSの病態機序の解明

2008 - 2010 L-plastin ; the possibility as a surrogate marker of polyglutamine diseases.

2008 - 2010 Amyotrophic lateral sclerosis and TDP-43 : elucidation of the entire neuropathological picture and molecular pathomechanism

2009 - 2009 遺伝性脳小血管病の病態機序の解明と治療法の開発

2008 - 2009 核内小体機能不全による非翻訳リボ核酸の異常による運動神経細胞死の研究

2007 - 2009 Impairment of quality control system for nucleic acids and neurodegenerative disorders.

2005 - 2009 Elucidation of molecular mechanisms of neurological diseases based on genome analysis

2007 - 2008 The spectrum of pathological involvement in Japanese multiple system atrophy

2005 - 2007 Atherapeutic approach to polyglutamine diseases by the activation of cellularproteolyticpathways

2004 - 2005 内在性相補鎖RNAによる遺伝子発現調節機構に注目したシヌクレイン関連蛋白の解析

2004 - 2005 New polyglutamine diseases : from the neuropathologies to the identification of genes responsible for the diseases

2003 - 2004 Transcriptional disturbance and Neurodegeneration.

2000 - 2004 Molecular mechanisms of neurodegeneration

2002 - 2003 Identified the causative gene for EAOH end elucidation the molecular mechanisms of neurodegeneration in EAOH

2001 - 2002 Research for the role of dystrophic neurites in neuronal cell dysfunction of Polyglutamine disease

2000 - 2001 Elucidation of molecular mechanisms of neurodegenerative diseases caused by expansion of CAG repeats

1999 - 2000 ポリグルタミン病における凝集体と神経細胞死の関連の解明と凝集体阻害剤の探求

Neurodegenerative diseases