Research field (6):
Genomics
, Applied molecular and cellular biology
, Chemical biology
, Home economics, lifestyle science
, Food sciences
, Functional biochemistry
2016 - 2018 Development of metabolic imaging using DNP-MRI and endogenous molecule as a probe
2015 - 2016 Spatially Resolved Metabolic Distribution for Unraveling the physiological Change and Response in Tomato Fruit by Spatially-resolved Metabolomics
2014 - 2016 Creation of Innovative Methodology for Analyzing in vivo Ambiguous Bioactivity of Anti-oxidative Substance to Support the Development of Health and Longevity-promoting Foods
2014 - 2015 Development of imaging technique for simultaneously visualizing dynamics of multiple dietary factors
2012 - 2014 Molecular design, synthesis, and molecular mechanism of MALDI-MS matrices
2010 - 2014 Elucidation of Sensory Systems for Food Factors in View of Molecular Epidemiology and Chemical Biology
2012 - 2013 高品質な食品の機能的デザインを支援する多次元情報統合化技術の開発
2012 - 2013 機能性食品成分の超簡便・超高感度センシング技術の開発
2013 - 2013 機能性食品成分の超簡便・超高感度センシング技術の開発
2012 - 2013 High-resolution analysis of bioresponse of functional food factor on the basis of metabolomics
2011 - 2013 Innovative multi-molecular imaging strategy toward comprehensive understanding of food factor signaling response contributed to the health promotion
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana. Regulatory effect of Epigallocatechin-3-O-gallate on circular RNA expression in mouse liver: Regulatory effect of EGCG on circRNA. The Journal of Nutritional Biochemistry. 2023. 109506-109506
Jaehoon Bae, Motofumi Kumazoe, Su-Jin Park, Yoshinori Fujimura, Hirofumi Tachibana. The anti-cancer effect of epigallocatechin-3-O-gallate against multiple myeloma cells is potentiated by 5,7-dimethoxyflavone. FEBS Open Bio. 2023
Mai Yamashita, Motofumi Kumazoe, Hiroaki Onda, Shun Hiroi, Yu Shimada, Yoshinori Fujimura, Hirofumi Tachibana. PPAR/PDK4 pathway is involved in the anticancer effects of cGMP in pancreatic cancer. Biochemical and Biophysical Research Communications. 2023. 672. 154-160
宮脇早希, 村田希, 村田希, 丸亀裕貴, 藤村由紀, 立花宏文. The effects of green tea polyphenol EGCG are mediated by extracellular vesicles derived from hepatocytes. 日本農芸化学会大会講演要旨集(Web). 2022. 2022
Metabolic profiling for the bioactivity evaluation of green tea and the selection of bioactivity-related chemical combinations.
(The 9th International Conference on Polyphenols and Health (ICPH2019) 2019)