Arai Shigeru

アライシゲル | Arai Shigeru

Affiliation and department：
Job title： associate professor

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (6)：複素環化学 , natural product synthesis , 不斉合成 , 有機合成化学 , Asymmetric Synthesis , Synthetic Organic Chemistry

Research theme for competitive and other funds (22)：

2022 - 2025 複雑複素環を有するアルカロイドの網羅的合成と創薬展開
2020 - 2021 コプシアアルカロイドをモチーフとする創薬有機化学
2017 - 2020 Development of transition metal-catalysis enabling selective functionalization and carbon-skeleton construction
2017 - 2018 多置換ベンゼンを網羅的かつ迅速に供給する触媒反応の探索
2013 - 2016 Development of Unprecedented Catalytic Carbocyanation

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Papers (87)：

Shinji Harada, Shihori Sekino, Marisa Inaba, Ayumi Okita, Tetsuhiro Nemoto, Shigeru Arai, Hitomi Ohmagari, Miki Hasegawa, Atsushi Nishida. Synthesizing Chiral Hydrocarbazoles with a Tetrasubstituted Carbon Using Holmium-Catalyzed Enantioselective [4 + 2] Cycloaddition: Mechanistic Insights from Luminescence and DFT Studies. The Journal of Organic Chemistry. 2024
Nanaka Ishihara, Shinji Harada, Masaya Nakajima, Shigeru Arai. Isatogenols as Precursors for the Synthesis of Fully Substituted Indolines through Regio- and Stereoselective [3 + 2] Cycloaddition Using Various Olefins. Organic Letters. 2024
Natsuki Ito, Shigeru Arai, Atsushi Nishida. Construction of C2-C3 Contiguous Stereogenic Centers in Indoline Derivatives by 1,3-Dipolar Cycloaddition. Asian Journal of Organic Chemistry. 2024
Ryoka Sakai, Nanaka Ishihara, Shinji Harada, Shigeru Arai. B(C6F5)3-catalyzed regio- and stereoselective cyanation of isatogens and their derivatives. Tetrahedron Letters. 2024
Shigeru Arai, Koichi Nakazawa, Xiao-Fei Yang, Masaya Nakajima, Shinji Harada, Atsushi Nishida. Nickel-catalysed regio- and stereoselective hydrocyanation of alkynoates and its mechanistic insights proposed by DFT calculations. Organic & Biomolecular Chemistry. 2024

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MISC (14)：

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Lectures and oral presentations (19)：

Synthesis of Nitrogen Heterocycles under Nickel Catalysis: Reaction Development and Its Application
(2019)
Nitrogen heterocycles: design, synthesis and applications
(2018)
アレンの特性を利用する複素環合成
(第47回複素環化学討論会(高知) 2017)
Allenes for versatile chemical transformations
(2017)
Total Synthesis of Kopsia Alkaloids
(2017)

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Professional career (1)：

Committee career (3)：

Awards (3)：

Association Membership(s) (2)：

有機合成化学協会 , 日本薬学会

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