Rchr

J-GLOBAL ID：200901076069823887 Update date: Sep. 01, 2024

Yamanouchi Keitaro

ヤマノウチケイタロウ | Yamanouchi Keitaro

Affiliation and department：

Research field (3)： Veterinary medicine , Animal production science , Cell biology

Research keywords (2)：筋再生学 , Cell Biology

Research theme for competitive and other funds (32)：

2023 - 2027 ラットを利用した筋ジストロフィーの病態解明空白地帯の解消
2022 - 2025 Development of innovative muscular dystrophy treatment with a novel ketogenic diet
2023 - 2024 老化細胞による筋再生抑制阻害剤の探索
2021 - 2023 リピドーム解析を利用した“真”の脂肪分化誘導因子の同定
2020 - 2023 間葉系前駆細胞の老化を基軸とした炎症性筋疾患の新規病態進行機序の解明

2023 - デュシェンヌ型筋ジストロフィーに対するミオスタチンを2重に阻害するアンチセンス核酸薬の開発

2020 - 2022 Study of nuclear-cytoplasmic incompatibility for the interspecies cloning.

2019 - 2021 Challenges in reconstructing myogenesis and muscle regeneration from a comparative animal science perspective

2019 - 2021 筋ジストロフィー新規治療法の探索

2016 - 2020 Mesenchymal progenitor cells as a niche factor of muscle tissues.

2016 - 2019 筋萎縮症の新規治療法開発

2015 - 2017 An attempt to improve pathology of muscular dystrophy model rats by preventing cellular senescence.

2011 - 2016 Physiological actions and pathological relevance of growth factors in the brain

2013 - 2016 Elucidating the mechanism of fat accumulation in skeletal muscle and its pathophysiological significance.

2009 - 2014 Analysis of Sex-dependent Epigenome

2009 - 2011 多能性幹細胞特異的受容体の同定による骨格筋内脂肪蓄積機構の解明

2008 - 2011 Studies on Brain Actions of the Steroid/Growth Factor System

2007 - 2010 Regulation of mesenchymal stem cell differentiation by growth hormone

2005 - 2008 筋衛星細胞を筋細胞・脂肪細胞へ分化させる運命決定因子の同定

2005 - 2007 Interaction of steroid hormones and growth factors in maintaining brain function

2001 - 2004 Studies on the action of sex steroids in the brain

2002 - 2003 肥満モデルラットを用いた骨格筋・脂肪組織間のクロストーク機構の解明

1999 - 2001 Studies for Production of Porcine Somatic Cell Clone Animals using Molecular Genetics

1998 - 2000 Studies on development of transgenic animals for use the in medical science.

1997 - 1998 哺乳類骨格筋の再生機構に関する分子細胞生物学的研究

1996 - 1998 Basic studies on production and application of transgenic animals in ruminants

1995 - 1997 反芻類家畜における形質転換動物作出技術の開発に関する研究

1996 - 1996 哺乳類胎盤形成における内膜組織浸潤の調節機構

1995 - 1996 Cloning and application of the genes regulating fecundity in mammals

1995 - 1996 Studies on Regulation of Macrophages Function during Nidation-Molecular and Cell Biological Studies-)

STUDIES ON DEVELOPMENT AND REGENERATION OF SKELETAL MUSCLES.

STUDIES ON SKELETAL MUSCLE REGENERATION OF MAMMALS

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Papers (150)：

Keitaro Yamanouchi, Shizuka Kato, Yukie Tanaka, Masanari Ikeda, Yukina Oshimo, Takanori Shiga, Kei Hatamoto, James Chambers, Takuya Imamura, Ryuji Hiramatsu, et al. Identification and characterization of dystrophin-locus-derived testis-specific protein: a testis-specific gene within the intronic region of the rat dystrophin gene. The Journal of reproduction and development. 2024
Ryota Tochinai, Koichi Kimura, Takeru Saika, Wataru Fujii, Hiroyuki Morita, Koki Nakanishi, Yoshiharu Tsuru, Shin-Ichi Sekizawa, Keitaro Yamanouchi, Masayoshi Kuwahara. Ivabradine ameliorates cardiomyopathy progression in a Duchenne muscular dystrophy model rat. Experimental animals. 2023
Yu-Wei Chang, Taichi Hatakeyama, Chia-Wei Sun, Masugi Nishihara, Keitaro Yamanouchi, Takashi Matsuwaki. Characterization of pathogenic factors for premenstrual dysphoric disorder using machine learning algorithms in rats. Molecular and cellular endocrinology. 2023. 576. 112008-112008
Masae Sato, Megumi Goto, Keitaro Yamanouchi, Hidetoshi Sakurai. A new immunodeficient Duchenne muscular dystrophy rat model to evaluate engraftment after human cell transplantation. Frontiers in physiology. 2023. 14. 1094359-1094359
Yuri Fujikura, Keitaro Yamanouchi, Hidetoshi Sugihara, Masaki Hatakeyama, Tomoki Abe, Satoru Ato, Katsutaka Oishi. Ketogenic diet containing medium-chain triglyceride ameliorates transcriptome disruption in skeletal muscles of rat models of duchenne muscular dystrophy. Biochemistry and biophysics reports. 2022. 32. 101378-101378

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MISC (51)：

合田祐貴, 西宏起, 山中大介, 山内啓太郎, 勝俣昌也, 片岡直行, 伯野史彦, 高橋伸一郎. 血中アミノ酸の低リジン高スレオニン状態は,骨格筋への脂質の蓄積を誘導する. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
Fumihiko Hakuno, Yuki Goda, Hiroki Nishi, Mikako Kumano, Daisuke Yamanaka, Keitaro Yamanouchi, Masaya Katsumata, Hisanori Kato, Masugi Nishihara, Shin-Ichiro Takahashi. LYSINE DEFICIENCY SIGNAL SELECTIVELY INDUCES LIPID ACCUMULATION IN MUSCLE AND ADIPOSE TISSUES OF RATS. ANNALS OF NUTRITION AND METABOLISM. 2017. 71. 447-447
田中良法, チェンバーズ・ジェームズ, 松脇貴志, 山内啓太郎, 西原真杉. プログラニュリン遺伝子欠如に特徴的な脳の病理におけるリソソーム機能不全の関与. Dementia Japan. 2014. 28. 4. 473-473
Role of non-structural protein of the extracellular matrix, SPARC, in sarcopenia. 2013. 64. 2. 132-138
Zeshan Ahmed, Hong Sheng, Ya-Fei Xu, Wen-Lang Lin, Amy E. Innes, Jennifer Gass, Xin Yu, Charles A. Wuertzer, Harold Hou, Shuichi Chiba, et al. Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging (vol 177, pg 311, 2010). AMERICAN JOURNAL OF PATHOLOGY. 2010. 177. 4. 2146-2146

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Lectures and oral presentations (35)：

Establishment of New Rat Model for Skeletal Muscle Research
(33rd PALAS Annual Scientific Conference 2024)
From Veterinary Medicine to Human Medicine: The Rat is Back
(NTU x UTokyo Joint Conference 2023)
ラットにおける遺伝子改変を利用した骨格筋再生の研究
(岡山理科大学獣医学部セミナー 2023)
ラットを用いた新たな筋再生学
(第468回北里大学獣医学科セミナー<Cutting Edge> 2022)
細胞老化は炎症性筋疾患の治療標的となりうる
(第20回日本再生医療学会総会シンポジウム「細胞・組織・個体老化と再生医療」 2021)

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Education (3)：

1991 - 1995 The University of Tokyo
1987 - 1991 The University of Tokyo
1985 - 1987 The University of Tokyo College of Arts and Sciences

Professional career (1)：

(BLANK) (The University of Tokyo)

Work history (5)：

2022/04 - 現在 The University of Tokyo Laboratory of Veterinary Physiology, Graduate School of Agricultural and Life Sciences Professor
2001/04 - 現在 The University of Tokyo Graduate School of Agricultural and Life Sciences
2000 - 2001 University of Arizona Muscle Biology Group, Nutritional Science Department Research Fellow
1995 - 2001 The University of Tokyo Graduate School of Agricultural and Life Sciences
1992 - 1994 University of Pittsburgh

Committee career (40)：

2023 - 現在日本獣医学会機関誌編集委員長
2022 - 現在日本畜産学会創立100周年記念事業実行委員会委員長
2021 - 現在農林水産省ゲノム編集の利用により得られた生物に関する生物多様性影響等検討会委員
2021 - 現在農林水産省カルタヘナ法・拡散防止措置確認会議動物検討会委員
2021 - 現在日本畜産学会副理事長

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Awards (2)：

2017 - 日本獣医学会日本獣医学会賞(第119号) 哺乳類骨格筋の発達と再生に関する研究
2015 - 伊藤記念財団第1回伊藤記念財団賞骨格筋前駆細胞群の分化制御機構解明を通じた高付価値食肉生産のための知的基盤の確立

Association Membership(s) (7)：

日本神経内分泌学会 , 日本筋学会 , THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE , 日本生殖内分泌学会 , 日本繁殖生物学会 , 日本獣医学会 , 日本畜産学会

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