Research field (4)：
Morphology, anatomy
, Ecology and environmental science
, Zoological sciences
, Environmental effects of chemicals
Research theme for competitive and other funds (32)：
2023 - 2027 Creation of a platform for the evaluation of signal toxicity, starting with the development of methods for the detection and diagnosis of brain function disruption.
2024 - 2025 Elucidation of mechanisms of transgenerational effects of developmental neurotoxicity - Developmental program and epigenomic toxicity of pesticides
2022 - 2025 Construction and practice of MITA system for more sensitive and efficient toxicity testing
2022 - 2025 Elucidation of mechanisms of transgenerational effects of developmental neurotoxicity - Developmental program and epigenomic toxicity of pesticides
2021 - 2024 Developmental neurotoxicity of pesticides based on the transgenerational inheritance and localized neural progenitor and glial cells activity
2019 - 2022 Development and practice of "adaptive risk assessment based on biological monitoring" of insecticide
2018 - 2022 Evaluation of Chemical Susceptibility Diversity Using the mlAOP Concept and Its Application to Elucidation of Pesticide Poisoning
2017 - 2020 Control of cell differentiation and proliferation by ultrasound: elucidation of the role of epigenome
2017 - 2020 The epigenetic status of Y chromosome in mammalian undifferentiated gonad
2016 - 2019 Elucidation of the molecular basis of sex difference and sex-specific epigenome regulation and maintenance mechanism in mammalian gonads
2014 - 2018 The Establishment of Endogenous Rural development Model by Expressing a Locality: An Actor-network approach
2014 - 2017 Relationships between the regulation mechanisms of sex differentiation and the epigenetic status in the developing gonad
2012 - 2016 Verification of relationships between dysfunction of the cell stress-protection system by exposures to multiple environmental chemicals and diseases
2012 - 2015 Tissue-dependent epigenetic regulation in the establishment of gonadal sex differences and its failure mechanisms
2009 - 2011 Molecular basis of epigenetics on the mechanisms of sex determination and its failure
2007 - 2008 The regulation mechanism of neural differentiation by AhR under hazardous environment
2007 - 2008 Effects of endocrine disruptor on reproductive function and epigenetic regulation
2006 - 2008 Evaluation of endocrine disruption action in wildlife, using Japanese field mice, Apodemus speciosus as a bio-indicator of Dioxins contamination
2004 - 2007 Analysis of the role of StAR binding protein (SBP) in the steroid hormone production
2005 - 2006 Molecular cytogenetic mechanisms of sex determination and differentiation in sexual dysgenesis
2003 - 2005 Isolation of Inhibin Receptor and Siginal Transuduction In TGF-β Superfamily
2003 - 2005 Elucidation of mechanisms on the sex differentiation gene family and its mutual regulation
2002 - 2004 Studies on the Identification and Signaling of Inhibin Receptors
2002 - 2003 Molecular toxicogenetic study on the differentiation of the next generation reproductive system by endocrine disruptors
2000 - 2003 Molecular analysis of steroidogenesis in the field of obstetrics and gynecology
2000 - 2001 Effects of fetal and neonatal exposure of male mice to diethylstilbestrol as endocrine disrupter on the reproductive and neuroendocrine system
1998 - 1999 Study on the sex differentiation relation genes and their mutual regulation
1998 - 1998 卵巣癌の女子発家系に関する臨床的・分子生物学的研究
1996 - 1997 Study on the Mechanisms of Initiation of Periventricular Leukomalacia Utilizing Chronic In Utero Preparation in the Preterm Fetal Sheep.
1996 - 1997 Molecular genetic study on sex determination, differentiation and sexual differentiation anomaly.
1988 - 1989 子宮内膜増殖及び分化機構における分子生物学的研究
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Papers (219)：
Anri Hirai, Chitoku Toda, Yared Beyene Yohannes, Nimako Collins, Mai Tamba, Kei Nomiyama, Akifumi Eguchi, Nobuhiko Hoshi, Tetsushi Hirano, Shouta M M Nakayama, et al. Role of brain monoamines in acetamiprid-induced anxiety-like behavior. Toxicology. 2024. 153839-153839
Shiori Kato, Toshifumi Yokoyama, Taisei Fujikawa, Yusuke Kirizuki, Youhei Mantani, Takanori Miki, Nobuhiko Hoshi. Establishment of an organ culture system to maintain the structure of mouse Müllerian ducts during development. The Journal of veterinary medical science. 2024. 86. 3. 300-307
Shota Murase, Youhei Mantani, Nobuhiko Ohno, Asaka Shimada, Satoki Nakanishi, Rinako Morishita, Toshifumi Yokoyama, Nobuhiko Hoshi. Regional differences in the ultrastructure of mucosal macrophages in the rat large intestine. Cell and tissue research. 2024
Tetsushi Hirano, Shuji Ohno, Yoshinori Ikenaka, Kanoko Onaru, Shizuka Kubo, Yuka Miyata, Mizuki Maeda, Youhei Mantani, Toshifumi Yokoyama, Collins Nimako, et al. Quantification of the tissue distribution and accumulation of the neonicotinoid pesticide clothianidin and its metabolites in maternal and fetal mice. Toxicology and applied pharmacology. 2024. 116847-116847
Yukako Hara, Asuka Shoda, Sakura Yonoichi, Yuya Ishida, Midori Murata, Mako Kimura, Makiko Ito, Sarika Nunobiki, Ayano Yoshimoto, Youhei Mantani, et al. No-observed-adverse-effect-level (NOAEL) clothianidin, a neonicotinoid pesticide, impairs hippocampal memory and motor learning associated with alteration of gene expression in cerebellum. The Journal of veterinary medical science. 2024
平野哲史, 池中良徳, 星信彦, 田渕圭章. Combined neurotoxic effects of multiple chemicals evaluated by common key events in AOP for neurotoxicity. 環境化学討論会要旨集(CD-ROM). 2022. 30th
HIRANO Tetsushi, IKENAKA Yoshinori, HOSHI Nobuhiko, TABUCHI Yoshiaki. Adverse outcome pathway (AOP)-based approach for assessing the combined neurotoxic effects of multiple pesticides. Annual Meeting of the Japanese Society of Toxicology. 2022. 49.1. P-4E
Adverse effects of pesticides on regional biodiversity and their mechanisms. In: Risks and Regulation of New Technologies
Springer 2021 ISBN:9789811586880
Serial Block face走査型電子顕微鏡を用いたラット回腸粘膜における単核食細胞系列の細胞の三次元的観察
(第124回日本解剖学会総会全国学術集会 2019)
Fabrication of a novel culture dish adapter with a small recess structure for flow control in a closed environment.
(International Conference on PharmScience Research & Development 2019 2019)
Adverse effects on cognitive-emotional behavior and immune system function in experimental animals administered a NOAEL-dose of neonicotinoids.
(Chemical Hazard Symposium in Hokkaido 2019)
