Noguchi Kazuma

ノグチカズマ | Noguchi Kazuma

Affiliation and department：
Job title： Professor

Research field (1)： Surgical dentistry

Research keywords (2)：臨床腫瘍学 , clinical oncology

Research theme for competitive and other funds (30)：

2022 - 2025 口腔扁平上皮癌の浸潤・転移におけるL1CAM発現の解析およびその影響
2022 - 2025 Research for the biomarker of invasionand metastasis of oral cancer with partial EMT
2021 - 2024 口腔扁平上皮癌におけるL1CAM発現の解析およびその影響
2019 - 2023 Analysis of fusion gene of salivary gland carcinogenesis and explore the molecular target agents
2018 - 2021 Inhibition of lymphatic metastasis in oral squamous cell carcinoma with the new anti-lymphangiogenic factor

2016 - 2019 Mechanism of acquired resistance and genome evolution treated with anti-cancer drug against oral cancer

2019 - 2019 頭頸部領域における線量吸収の少ない放射線治療用口腔装置の開発応用

2015 - 2018 Development of new molecular target chemotherapy using in vitro oral carcinogenesis model

2015 - 2018 Analysis of Gorlin syndrome derived benign or malignant tumor

2015 - 2018 Inibition of lymphangiogenesis in oral squamous cell carcinoma

2014 - 2016 Analysis of acquired resistance mechanism to cisplatin in human oral squamous cell carcinoma

2013 - 2016 Investigation of microRNA as a biomarker in recurrence and metastasis of oral cancer

2013 - 2016 Chemotherateutic strategy for recurrence of oral cancer inhibiting Hedgehog signaling

2012 - 2015 Analysis of Hedgehog signaling using Gorlin syndrome derived cells

2010 - 2012 Molecular analysis of oral carcinogenesis with in vitro multistepcarcinogenesis model

2010 - 2012 A study on interaction of cancer stem cells and microenvironment (niche)and stromal fibroblasts (CAF)

2009 - 2011 Isolation and identification of oral cancer stem cells and development of specific therapy for cancer stem cells

2007 - 2009 Establishment of immortalized normal salivary glands epithelial cells and regeneration of salivary gland for post-irradiation

2006 - 2008 Analysis of mechanisms of oral cancer metastasis via chemokine signals and molecular target therapy for inhibition of metastasis

2004 - 2006 腺様嚢胞癌における特異的な肺転移メカニズムの解明

2001 - 2002 上顎洞原発小細胞癌培養細胞株における生物学的特性と分化誘導の検討

2000 - 2002 Establishment of human adenoid cystic carcinoma cell lines with high lung metastasis and analysis of lung metastasis mechanism.

2000 - 2002 Expression of cyclooxygenase (COX)-2 in head and neck cancer and inhibitory effect of COX-2 inhibitors on tumor growth

1999 - 2000 ヒト口腔癌に対する血管新生阻害剤と放射線併用療法による抗腫瘍効果の検討

細胞の不死化を応用した病態モデルの作成

口腔がんにおける発がん機序の解析

口腔癌および唾液腺癌の転移機序の解析

differentiation of Small cell carcinoma.

Analysis of metastasis in oral and salivary gland cancer

Biological features of small cell carcinoma derived from human maxillary sins

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Papers (85)：

Yuji Omori, Kazuma Noguchi, Mizuha Kitamura, Yuna Makihara, Takayuki Omae, Soutaro Hanawa, Kyohei Yoshikawa, Kazuki Takaoka, Hiromitsu Kishimoto. Bacterial Lipopolysaccharide Induces PD-L1 Expression and an Invasive Phenotype of Oral Squamous Cell Carcinoma Cells. Cancers. 2024. 16. 2
Kuniyasu Moridera, Kazuhiro Kitajima, Kyohei Yoshikawa, Kazuki Takaoka, Tatsuya Tsuchitani, Kazuma Noguchi, Hiromitsu Kishimoto, Koichiro Yamakado. Usefulness of quantitative bone SPECT/CT for evaluating medication-related osteonecrosis of the jaw treatment response. Japanese journal of radiology. 2023. 41. 7. 760-767
Hanako Araki-Maeda, Mutsuki Kawabe, Yuji Omori, Koji Yamanegi, Kazunari Yoshida, Kyohei Yoshikawa, Kazuki Takaoka, Kazuma Noguchi, Yoshiro Nakano, Hiromitsu Kishimoto. Establishment of an oral squamous cell carcinoma cell line expressing vascular endothelial growth factor a and its two receptors. Journal of dental sciences. 2022. 17. 4. 1471-1479
Kuniyasu Moridera, Kazuhiro Kitajima, Kyohei Yoshikawa, Kazuki Takaoka, Tatsuya Tsuchitani, Kazuma Noguchi, Hiromitsu Kishimoto, Koichiro Yamakado. Usefulness of quantitative bone SPECT/CT for medication-related osteonecrosis of the jaw in clinical settings. Japanese journal of radiology. 2022. 40. 5. 492-499
Kazuma Noguchi, Shuji Kanda, Kazunari Yoshida, Yusuke Funaoka, Koji Yamanegi, Kyohei Yoshikawa, Kazuki Takaoka, Hiromitsu Kishimoto, Yoshiro Nakano. Establishment of a patient-derived mucoepidermoid carcinoma cell line with the CRTC1-MAML2 fusion gene. Molecular and clinical oncology. 2022. 16. 3. 75-75

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MISC (47)：

芝辻豪士, 野口一馬, 山根木康嗣, 岸本裕充, 足立了平. 多数歯の根吸収を伴った腺腫様歯原性腫瘍の1例. 日本口腔科学会雑誌. 2017. 66. 2. 137-137
Michiyo Yamamura, Kazuma Noguchi, Yoshiro Nakano, Emi Segawa, Yusuke Zushi, Kazuki Takaoka, Hiromitsu Kishimoto, Tomoko Hashimoto-Tamaoki, Masahiro Urade. Functional analysis of Zyxin in cell migration and invasive potential of oral squamous cell carcinoma cells (vol 42, pg 873, 2013). INTERNATIONAL JOURNAL OF ONCOLOGY. 2016. 49. 5. 2188-2188
長谷川陽子, 白水雅子, 松本美紀, 田路知香子, 竹野々暁子, 坪内英之, 山内義之, 川邊睦記, 野口一馬, 岸本裕充. ダウン症候群患者の歯の動揺に対して上下顎バイトプレートを使用した1症例. 障害者歯科. 2016. 37. 3. 336-336
岸本裕充, 長谷川陽子, 高岡一樹, 野口一馬. 食べられる口を CREATEするためのオーラルマネジメント. 日本静脈経腸栄養学会雑誌. 2016. 31. 2. 687-692(J-STAGE)
藤原正識, 高岡一樹, 野口一馬, 長谷川陽子, 門井謙典, 岸本裕充. 遷延性意識障害患者に対し全顎的重度歯周炎のため多数歯抜歯を施行した1例. 障害者歯科. 2015. 36. 3. 459-459

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Professional career (1)：

医学博士 (兵庫医科大学)

Awards (1)：

2001 - (社)日本口腔外科学会総会優秀ポスター賞

Association Membership(s) (5)：

日本口腔外科学会 , 日本口腔科学会 , 日本頭頚部腫瘍学会 , 日本癌学会 , International Society of Oral and Maxillofacial Surgery

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