Rchr
J-GLOBAL ID：200901076137303650   Update date: Oct. 15, 2024

Tsuchiya Yoshiki

ツチヤ ヨシキ | Tsuchiya Yoshiki
Affiliation and department：
Kyoto Prefectural University of Medicine

About Kyoto Prefectural University of Medicine


Research field  (5)： Physiology ,  Clinical pharmacy ,  Systems genomics ,  Cell biology ,  Molecular biology
Research keywords  (14)： 転写制御 ,  時計遺伝子 ,  リン酸化 ,  翻訳後修飾 ,  ゲノム編集 ,  サーカディアンリズム ,  転写因子 ,  体内時計 ,  温度補償性 ,  概日リズム ,  細胞内シグナル伝達 ,  ストレス応答 ,  intracellular signal transduction ,  stress response
Research theme for competitive and other funds  (13)：
  • 2018 - 2021 Function of REV-ERBa/b in regulation of cellular circadian physiology
  • 2016 - 2019 Understanding of the mechanism underlying gene expression rhythms using a gene circuit model with engineered Cas9 transcription factors
  • 2015 - 2018 Identification of temperature compensation mechanisms in the mammalian circadian clock
  • 2012 - 2014 Epigenetic regulation of circadian clock development during ES cell differentiation
  • 2010 - 2011 Advanced investigation of molecular regulation of lipid metabolism by the transcription factor Nrf1
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Papers (40)：
  • Nobuya Koike, Yasuhiro Umemura, Hitoshi Inokawa, Isao Tokuda, Yoshiki Tsuchiya, Yuh Sasawaki, Atsushi Umemura, Naoko Masuzawa, Kazuya Yabumoto, Takashi Seya, et al. Inter-individual variations in circadian misalignment-induced NAFLD pathophysiology in mice. iScience. 2024. 27. 2. 108934-108934
  • Hiroko Nakai, Yoshiki Tsuchiya, Nobuya Koike, Taiki Asano, Morio Ueno, Yasuhiro Umemura, Yuh Sasawaki, Ryutaro Ono, Junji Hamuro, Chie Sotozono, et al. Comprehensive Analysis Identified the Circadian Clock and Global Circadian Gene Expression in Human Corneal Endothelial Cells. Investigative ophthalmology & visual science. 2022. 63. 5. 16-16
  • 小池 宣也, 梅村 康浩, 井之川 仁, 笹脇 ゆふ, 土谷 佳樹, 八木田 和弘. 階層を超えた包括的フェノタイプ解析による概日リズム障害成立プロセスの解明. 日本生理学雑誌. 2022. 84. 1. 30-30
  • Yasuhiro Umemura, Nobuya Koike, Yoshiki Tsuchiya, Hitomi Watanabe, Gen Kondoh, Ryoichiro Kageyama, Kazuhiro Yagita. Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 1
  • Ryutaro Ono, Makoto Abe, Nobuya Koike, Hitoshi Inokawa, Yoshiki Tsuchiya, Yasuhiro Umemura, Yuh Sasawaki, Toshiro Yamamoto, Satoshi Wakisaka, Narisato Kanamura, et al. Quantitative morphometric analysis of molar teeth and alveolar bone using micro-computed tomography in aged mice. Journal of oral biosciences. 2021. 63. 3. 265-270
ｍore...
MISC (25)：
  • 小池宣也, 梅村康浩, 井之川仁, 井之川仁, 笹脇ゆふ, 土谷佳樹, 八木田和弘. 階層を超えた包括的フェノタイプ解析による概日リズム障害成立プロセスの解明. 日本生理学雑誌(Web). 2022. 84. 1
  • 梅村康浩, 小池宣也, 土谷佳樹, 渡邊仁美, 近藤玄, 影山龍一郎, 影山龍一郎, 八木田和弘. 概日時計コア因子CLOCK/BMAL1による体節時計振動への干渉作用. 日本生理学雑誌(Web). 2022. 84. 1
  • 土谷 佳樹, 八木田 和弘. 【時間生物学と医療の融合-現状と将来-】体内時計のミスアライメントによる恒常性破綻. Medical Science Digest. 2021. 47. 8. 408-411
  • 小池宣也, 梅村康浩, 井之川仁, 井之川仁, 笹脇ゆふ, 土谷佳樹, 八木田和弘. Systematic phenotyping in presymptomatic state of circadian rhythm disorders. 時間生物学. 2021. 27. 2
  • 小野龍太郎, 小野龍太郎, 小池宣也, 井之川仁, 土谷佳樹, 梅村康浩, 山本俊郎, 金村成智, 八木田和弘. A New Insight of Tooth Growth~8-hour Ultradian Increments in Mouse Molar Dentin~. Journal of Oral Biosciences Supplement (Web). 2020. 2020
ｍore...
Books (1)：
  • 時間生物学事典 - 16. 温度補償性 (共著)
    朝倉書店 2008
Lectures and oral presentations  (3)：
  • Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms.
    (第34回日本分子生物学会年会 2011)
  • The role of CK2 in the regulation of the mammalian circadian rhythms.
    (6th International Conference on Protein Kinase CK2. 2010)
  • 哺乳類概日時計におけるCK2 の役割
    (第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会 2007)
Education (5)：
  • 2000 - 2005 Kyoto University Graduate School of Biostudies Division of Integrated Life Science
  • - 2005 Kyoto University Graduate School, Division of Life Science
  • - 2002 Kyoto University Graduate School, Division of Life Science
  • 1996 - 2000 Kyoto University Faculty of Science
  • - 2000 Kyoto University Faculty of Science
Professional career (2)：
  • 博士(生命科学) (京都大学)
  • 修士(生命科学) (京都大学)
Work history (4)：
  • 2012/04 - 現在 Kyoto Prefectural University of Medicine
  • 2008/04 - 2012/03 Doshisha University Faculty of Life and Medical Sciences, Department of Medical Life Systems Assistant Professor
  • 2005/04 - 2008/03 Kyoto University Graduate School of Biostudies
  • 2004/04 - 2005/03 日本学術振興会特別研究員(DC2)
Association Membership(s) (4)：
JAPANESE SOCIETY FOR CHRONOBIOLOGY ,  THE PHYSIOLOGICAL SOCIETY OF JAPAN ,  日本分子生物学会 ,  日本ゲノム編集学会
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