Akita Tenpei

アキタテンペイ | Akita Tenpei

Affiliation and department：
Job title： Professor

Research field (3)： Physiology , Neuropathology , Neuroscience - general

Research keywords (30)： neural development , cell migration , epilepsy , membrane excitability regulation , 細胞容積調節 , ATP , カルシウムナノドメイン , ブラジキニン , カルシウムイオン , アストログリア , 化学伝達物質 , グルタミン酸 , 国際研究者交流 , イオンチャネル , ベラルーシ , 細胞間情報伝達 , 細胞容積感受性アニオンチャネル , 活性酸素種 , 細胞膜伸展 , 蛋白-蛋白相互作用 , モーダルシフト , アニオンチャネル , ROSセンサー , 容積センサー , カチオンチャネル , メカノセンサー , 神経生理学 , 細胞生理学 , Neurophysiology , Cell Physiology

Research theme for competitive and other funds (13)：

2022 - 2025 Exploration of Therapeutic Target Molecules for Developmental and Epileptic Encephalopathies with Decreased Repetitive Firing Activity of Pyramidal Neurons
2021 - 2024 Elucidating regulatory mechanisms for neural precursor development by voltage-dependent ion channels
2017 - 2021 Exploration of the integrated physiological mechanism of membrane excitability regulation through analyses of disease-causing gene mutations
2017 - 2019 Developmental disorder model based on fetal hypothalamic GABA-Cl system disturbances
2014 - 2018 Exploring the mechanisms for neuronal migration and intercellular communication steered by ion channels in the embryonic brain

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Papers (35)：

Adya saran Sinha, Sumiya Shibata, Yasuyuki Takamatsu, Tenpei Akita, Atsuo Fukuda, Tatsuya Mima. Static magnetic field stimulation enhances shunting inhibition via a SLC26 family Cl^-channel, inducing intrinsic plasticity. The Journal of Neuroscience. 2024. e1324222024-e1324222024
Takuya Hiraide, Tenpei Akita, Kenji Uematsu, Sachiko Miyamoto, Mitsuko Nakashima, Masayuki Sasaki, Atsuo Fukuda, Mitsuhiro Kato, Hirotomo Saitsu. A novel de novo KCNB1 variant altering channel characteristics in a patient with periventricular heterotopia, abnormal corpus callosum, and mild seizure outcome. Journal of Human Genetics. 2022. 68. 1. 25-31
Adya Saran Sinha, Tianying Wang, Miho Watanabe, Yasushi Hosoi, Eisei Sohara, Tenpei Akita, Shinichi Uchida, Atsuo Fukuda. WNK3 kinase maintains neuronal excitability by reducing inwardly rectifying K+ conductance in layer V pyramidal neurons of mouse medial prefrontal cortex. Frontiers in Molecular Neuroscience. 2022. 15. 856262-856262
Hosoi Y, Akita T, Watanabe M, Ito T, Miyajima H, Fukuda A. Taurine depletion during fetal and postnatal development blunts firing responses of neocortical layer II/III pyramidal neurons. Frontiers in Molecular Neuroscience. 2022. 15. 806798-806798
Kazushi Aoto, Mitsuhiro Kato, Tenpei Akita, Mitsuko Nakashima, Hiroki Mutoh, Noriyuki Akasaka, Jun Tohyama, Yoshiko Nomura, Kyoko Hoshino, Yasuhiko Ago, et al. ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H+-ATPases is essential for brain development in humans and mice. Nature Communications. 2021. 12. 1. 2107-2107

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MISC (69)：

片山はるみ, 村松妙子, 青木好美, 長嶋英里, 金原あみ, 秋田天平, 看護学科カリキュラム委員会. 【新カリキュラム施行から1年看護基礎教育の今を探る】(Part 3)新年度から新たに取り組む科目の展望アクティブラーナーを育てる. 看護展望. 2023. 48. 4. 0412-0416
秋田天平, 青戸一司, 才津浩智, 福田敦夫. 発達性てんかん性脳症を引き起こすKv2.1 R306C変異の大脳皮質錐体神経発火活動への影響について. 日本生理学雑誌. 2022. 84. 1. 10-11
秋田天平, 福田敦夫. 胎生脳内側基底核原基の神経前駆細胞における2種類の電位依存性陽イオン電流の発見. 日本生理学雑誌. 2021. 83. 2. 18-18
秋田天平, 福田敦夫. 胎生脳内側基底核原基の神経前駆細胞における2種類の電位依存性陽イオン電流の発見. 日本生理学雑誌. 2021. 83. 2. 18-18
SINHA Adya Saran, WANG Tianying, MUTOH Hiroki, AKITA Tenpei, YANAGAWA Yuchio, KAWAI Tomoko, HATA Kenichiro, FUKUDA Atsuo. Gad1 heterozygotes subjected to prenatal stress undergo epigenetic dysregulation of genes perturbing neurodevelopment and behavior. 日本生理学雑誌(Web). 2021. 83. 2

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Books (9)：

"Regulation of neuronal cell migration and cortical development by chloride transporter activities." In Neuronal Chloride Transporters in Health and Disease
Academic Press, Elsevier 2020
「塩素チャネル」脳科学辞典 http://bsd.neuroinf.jp/wiki/塩素チャネル
日本神経科学学会 2013
Patch-clamp techniques: general remarks.
In Patch Clamp Techniques: From Beginning to Advanced Protocols, ed. Okada Y, Springer Protocols Handbooks, Springer 2012
最新パッチクランプ実験技術法「2章パッチクランプ法総論」
吉岡書店 2011
「シナプス前終末の細胞内Ca2+遊離とシナプスの可塑性」蛋白質核酸酵素
2000

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Lectures and oral presentations (2)：

Volume-sensitive outwardly rectifying anion channels in the developing brain.
(Cell Volume Regulation: Novel Therapeutic Targets and Pharmacological Approaches 2013)
Ca2+ nanodomain-mediated regulation of volume-sensitive outwardly rectifying (VSOR) anion channels in mouse astrocytes.
(Cell Volume Regulation Meeting 2011 Hydration & Cell Volume Regulation 2011)

Education (2)：

1996 - 2001 Nagoya University Graduate School of Medicine Department of Physiology
1990 - 1996 Saga Medical School

Professional career (1)：

Doctor(Medicine) (Nagoya University)

Work history (6)：

2022/01 - 現在 Hamamatsu University School of Medicine Division of Health Science, Department of Basic Nursing Professor
2012/11 - 2021/12 Hamamatsu University School of Medicine Department of Neurophysiology Associate Professor
2008/06 - 2012/11 National Institute for Physiological Sciences Department of Cell Physiology Assistant Professor
2007/03 - 2008/06 岡崎市医師会公衆衛生センター非常勤医師
2004/04 - 2007/03 Nagoya University of Arts and Sciences Postdoctoral fellow

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Committee career (2)：

2015/01 - 現在日本生理学会生理学エデュケーター
2012/03 - 現在日本生理学会評議員

Awards (1)：

2012/03 - The Physiological Society of Japan The 89th Annual Meeting of The Physiological Society of Japan Poster Award Ca2+ nanodomain-mediated component of swelling-induced volume-sensitive outwardly rectifying (VSOR) anion channel activity in mouse astrocytes.

Association Membership(s) (4)：

Japan Brain Science Society , JAPAN EPILEPSY SOCIETY , THE JAPAN NEUROSCIENCE SOCIETY , 日本生理学会

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