2021 - 2026 Elucidation of the mechanism of rhodopsin functions for optogenetics
2024 - 2025 Development of in situ Single Particle Analysis (SPA) using Wedge-shaped Samples
2021 - 2024 Multi-scale platform for untangling physiological complexity
2021 - 2024 過渡的タンパク質複合体の高速構造解析プラットフォームの構築
2021 - 2024 Clarification of the signal transduction mechanism of hetero-dimerized opioid receptors that cause side effects of opioids
2021 - 2024 μおよびδオピオイド受容体二量体のがん疼痛維持機構における役割の解明
2019 - 2024 Structural analysis of G protein/Arrestin-GPCR complex for development of biased ligands
2019 - 2022 Structure-based analysis of the central itch receptors aiming at development of new medicine for chronic itch and cancer
2019 - 2022 Elucidation of the molecular basis governing the construction of spinal neural circuits involved in visceral pain transmission
2019 - 2022 Elucidation of chronic pain-specific intraspinal transmission circuits modulated by BEGAIN and drug development
2015 - 2018 Differential analysis of the crystal structures of active / inactive orexin receptor contributing to rational development of sleep control drug
2014 - 2015 Development of efficient protein production system by photo-driven ATP regenerating vesicle
2007 - 2008 X-ray crystallographic study of membrane-bound ATP-dependent protease FtsH
2007 - 2008 膜結合型ATP依存性メタロプロテアーゼFtsHの一分子解析
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Papers (32):
Shun Yokoi, Ryoji Suno, Ayori Mitsutake. Structural and Computational Insights into Dynamics and Intermediate States of Orexin 2 Receptor Signaling. The journal of physical chemistry. B. 2024. 128. 25. 6082-6096
Suno-Ikeda C, Nishikawa R, Suzuki R, Iwata S, Takai T, Ogura T, Hirose M, Inoue A, Asai E, Kise R, et al. Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor. 2024
Ryoji Suno. Exploring Diverse Signaling Mechanisms of G Protein-Coupled Receptors through Structural Biology. Journal of biochemistry. 2024. 175. 4. 357-365
Kota Katayama, Ryoji Suno. Holistic concepts in GPCR dynamics. Biophysics and Physicobiology. 2024. 21. 1. e210011
Kayo Imamura, Ken-Ichi Akagi, Yohei Miyanoiri, Hirokazu Tsujimoto, Takatsugu Hirokawa, Hideo Ashida, Kaori Murakami, Asuka Inoue, Ryoji Suno, Takahisa Ikegami, et al. Interaction modes of human orexin 2 receptor with selective and nonselective antagonists studied by NMR spectroscopy. Structure. 2024. 32. 3. 352-361