Rchr
J-GLOBAL ID：200901076796947327   Update date: Oct. 11, 2024

Kitahara Ryo

キタハラ リョウ | Kitahara Ryo
Affiliation and department：
Ritsumeikan University College of Pharmaceutical Sciences, Department of Pharmaceutical Sciences

About Ritsumeikan University College of Pharmaceutical Sciences, Department of Pharmaceutical Sciences


Job title： Professor
Other affiliations (1)：
  • Ritsumeikan University  Research Organization of Science and Technology, Research Center for Drug Discovery and Development Scieces 
Homepage URL  (1)： http://www.ritsumei.ac.jp/pharmacy/kitahara/kitahara_lab.html
Research field  (3)： Pharmaceuticals - analytical and physicochemistry ,  Structural biochemistry ,  Biophysics
Research keywords  (1)： protein, pressure, structure, semi-stable conformer, conformational fluctuation
Research theme for competitive and other funds  (12)：
  • 2023 - 2026 冬眠する細胞が持つ圧力耐性-新たな網膜疾患治療戦略への展開
  • 2020 - 2022 分子夾雑と生物時計
  • 2019 - 2022 Pressure effects on the cyanobacterial circadian clock
  • 2014 - 2017 Research on the molecular basis of conformational dynamics of oncogene product Ras for application to the development of its specific inhibitors
  • 2013 - 2016 High-energy conformations of proteins as a new target of structural biology
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Papers (68)：
  • Keiji Kitamura, Ayano Oshima, Fuka Sasaki, Yutaro Shiramasa, Ryu Yamamoto, Tomoshi Kameda, Soichiro Kitazawa, Ryo Kitahara. Modulation of Biomolecular Liquid-Liquid Phase Separation by Preferential Hydration and Interaction of Small Osmolytes with Proteins. The journal of physical chemistry letters. 2024. 15. 30. 7620-7627
  • Yutaro Shiramasa, Ryu Yamamoto, Norika Kashiwagi, Fuka Sasaki, Sawaka Imai, Mikihito Ike, Soichiro Kitazawa, Tomoshi Kameda, Ryo Kitahara. An aberrant fused in sarcoma liquid droplet of amyotrophic lateral sclerosis pathological variant, R495X, accelerates liquid-solid phase transition. Scientific reports. 2024. 14. 1. 8914-8914
  • Ryo Kitahara, Tomoshi Kameda. Phase separation by biopolymers: Basics and applications. Biophysics and physicobiology. 2022. 19. e190028
  • Ryo Kitahara, Ryota Yamazaki, Fumika Ide, Shujie Li, Yutaro Shiramasa, Naoya Sasahara, Takuya Yoshizawa. Pressure-Jump Kinetics of Liquid-Liquid Phase Separation: Comparison of Two Different Condensed Phases of the RNA-Binding Protein, Fused in Sarcoma. Journal of the American Chemical Society. 2021. 143. 47. 19697-19702
  • Shujie Li, Takuya Yoshizawa, Ryota Yamazaki, Ayano Fujiwara, Tomoshi Kameda, Ryo Kitahara. Pressure and Temperature Phase Diagram for Liquid-Liquid Phase Separation of the RNA-Binding Protein Fused in Sarcoma. JOURNAL OF PHYSICAL CHEMISTRY B. 2021. 125. 25. 6821-6829
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MISC (14)：
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Patents (1)：
  • TDP-43の凝集体が蓄積する疾患を治療及び/又は予防するための化合物のスクリーニング方法
Books (4)：
  • Molecular Science of Fluctuations toward Biological Functions [NMR explorations of biomolecular systems with rapid conformational exchanges]
    Springer 2016 ISBN:9784431558385
  • High Pressure Bioscience [High pressure NMR discloses functional sub-states of ubiquitin and ubiquitin-like proteins]
    Springer 2015 ISBN:9789401799171
  • 「揺らぎ・ダイナミクスと生体機能」 寺嶋正秀編
    化学同人 2013 ISBN:9784759815108
  • 広がるNMRの世界(朝倉哲郎編) 「高圧力NMRで見る蛋白質の高エネルギー構造の世界」の1トピックス
    コロナ社 2011
Lectures and oral presentations  (150)：
  • Water-protein interactions coupled with protein conformational transition
    (第57回日本生物物理学会年会 2019)
  • Rational design of peptide targeting intrinsically disordered protein p53-reguation of function and phase-phase separation-
    (第57回日本生物物理学会年会 2019)
  • Pressure accelerates the circadian clock of cyanobacteria
    (第57回日本生物物理学会年会 2019)
  • Current trend of phase separation
    (第57回日本生物物理学会年会 2019)
  • High-pressure NMR study of the locally disordered conformation of outer surface protein A (OspA)
    (8th Asia-Pacific NMR Symposium 2019 2019)
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Works (3)：
  • 特別講演
    2007 -
  • seminar: A new paradigm of protein structures
    2006 -
  • seminar:Exploring the entire conformational space of proteins by high pressure NMR
    2004 -
Education (3)：
  • - 2002 Kobe University Graduate School of Science and Technology Department of Molecular Science
  • - 1999 Ritsumeikan University "Graduate School, Division of Science and Engineering"
  • - 1997 Ritsumeikan University Faculty of Science and Engineering Department of Chemistry
Professional career (1)：
  • Ph.D. (Science) (Kobe University)
Work history (8)：
  • 2017/04/01 - 2018/03/31 Osaka University Institute for Protein Research
  • 2011/04/01 - 2017/03/31 Ritsumeikan University, Colleges of Pharmaceutical Science
  • 2008/04/01 - 2011/03/31 Ritsumeikan University, Colleges of Pharmaceutical Science
  • 2008/04/01 - 2010/03/01 理化学研究所・客員研究員
  • 2009/11/16 - Shiga University of Medical Science
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Committee career (5)：
  • 2017/04 - 2019/03 日本核磁気共鳴学会 評議員
  • 2012/04 - 2014/04 日本生物物理学会 「生物物理」編集委員
  • 2012/04 - 2014/03 日本核磁気共鳴学会評議員
  • 2008 - 生物物理編集地区委員
  • 2008 - 生物物理学会 専門委員
Awards (2)：
  • 2006/11 - 日本生物物理学会 生物物理学会 若手奨励賞
  • 2005/11 - NMR討論会ポスター賞
Association Membership(s) (7)：
American Chemical Society ,  The Pharmaceutical Society of Japan ,  The Japan SOciety of High Pressure Science and Technology ,  The NMR Society of Japan ,  The Protein Science Society of Japan ,  Biophysical Society ,  The Biophysical Society of Japan
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