Rchr
J-GLOBAL ID：200901077008313637   Update date: Apr. 25, 2024

Iwai Kazuhiro

イワイ カズヒロ | Iwai Kazuhiro
Affiliation and department：
Kyoto University Graduate School of Medicine

About Kyoto University Graduate School of Medicine


Homepage URL  (2)： http://www.mcp-kyoto-u.jp ,  http://www.med.kyoto-u.ac.jp/en/organization-staff/research/doctoral_course/r-004/
Research field  (4)： Pathobiochemistry ,  Medical biochemistry ,  Cell biology ,  Functional biochemistry
Research keywords  (4)： 包括脳ネットワーク ,  iron metabolism ,  NF-kB ,  ubiquitin
Research theme for competitive and other funds  (49)：
  • 2022 - 2027 Integrated analyses of LUBAC-mediated linear ubiquitination
  • 2022 - 2025 Involvement of linear ubiquitination in regulation of cancer and immunity
  • 2018 - 2023 New frontier for ubiquitin biology driven by chemo-technologies
  • 2018 - 2023 Functional regulation of ubiquitin chains using chemo-technologies
  • 2017 - 2022 Extensive analyses of the LUBAC ubiquitin ligase
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Papers (171)：
  • Yukiko Takeda, Masahiro Ueki, Junpei Matsuhiro, Erik Walinda, Takayuki Tanaka, Masafumi Yamada, Hiroaki Fujita, Shunichiro Takezaki, Ichiro Kobayashi, Sakura Tamaki, et al. A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome. The Journal of experimental medicine. 2024. 221. 6
  • Kentaro Akagi, Shiro Baba, Hiroaki Fujita, Yasuhiro Fuseya, Daisuke Yoshinaga, Hirohito Kubota, Eitaro Kume, Fumiaki Fukumura, Koichi Matsuda, Takayuki Tanaka, et al. HOIL-1L deficiency induces cell cycle alteration which causes immaturity of skeletal muscle and cardiomyocytes. Scientific reports. 2024. 14. 1. 8871-8871
  • Erik Walinda, Kenji Sugase, Naoki Ishii, Masahiro Shirakawa, Kazuhiro Iwai, Daichi Morimoto. Solution structure of the HOIL-1L NZF domain reveals a conformational switch regulating linear ubiquitin affinity. Journal of Biological Chemistry. 2023. 105165-105165
  • Katsuhiro Sasaki, Yoshie Hayamizu, Ryuji Murakami, Masakazu Toi, Kazuhiro Iwai. Linear ubiquitination-induced necrotic tumor remodeling elicits immune evasion. FEBS Letters. 2023
  • Sota Kuno, Kazuhiro Iwai. Oxygen modulates iron homeostasis by switching iron-sensing of NCOA4. Journal of Biological Chemistry. 2023. 104701-104701
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MISC (25)：
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Patents (4)：
  • UBIQUITIN LIGASE HAVING LINEAR POLYUBIQUITINATIONACTIVITY AND USE THEREOF
  • UBIQUITIN LIGASE AND USE THEREOF
  • 新規なユビキチンリガーゼおよびその利用
  • 破骨細胞制御剤とそのスクリーニング方法
Lectures and oral presentations  (47)：
  • Mechanisms underlying the formation and destabilization of the LUBAC ligase complex.
    (Cold Spring Harbor Asia Conference “Ubiquitin Family, Autophagy & Diseases” 2018)
  • Linear ubiquitin chains: NF-kappaB activation, cell death, and oncogenesis
    (2017 International protein metabolism and disease conference 2017)
  • Differential involvement of subunits of LUBAC ubiquitin ligase in signalling and cell death.
    (EMBO Conference “Ubiquitin and ubiquitin-like modifiers: From molecular mechanisms to human diseases 2015)
  • Linear ubiquitin chains: NF-kappaB activation, cell death, and cancer.
    (International Symposium on Ubiquitin and Diseases. 2015)
  • Linear ubiquitin chains: a new regulator of NF-kappaB activation and cell death signaling.
    (1st SPS International Symposium Xiamen University 2015)
ｍore...
Education (2)：
  • - 1992 Kyoto University
  • - 1985 Kyoto University Faculty of Medicine
Professional career (1)：
  • Doctor of Medical Science (Kyoto University)
Work history (8)：
  • 2012/04 - 現在 Graduate School of Medicine, Kyoto University Professor
  • 2008/04 - 2012/03 大阪大学大学院・生命機能研究科/医学系研究科 教授
  • 2001/07 - 2008/03 Graduate School of Medicine, Osaka City University Professor
  • 1999 - 2001 京都大学大学院・生命科学研究科 助教授
  • 1997 - 1999 京都大学大学院・医学研究科 助教授
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Committee career (2)：
  • 2019/11 - 現在 日本生化学会 理事
  • 2013 - 現在 日本鉄バイオサイエンス学会 理事
Awards (5)：
  • 2021/06 - The Japan Academy Japan Academy Prize
  • 2020/03 - The Uehara Memorial Foundation Uehara Prize
  • 2019/11 - Takeda Science Foundation Takeda Medical Prize
  • 2017/11 - Mochida Memorial Foundation for Medical and Pharmaceutical Research Academic Award of the Mochida Memorial Foundation
  • 2015/11 - The Japan Medical Association Medical Award of The Japan Medical Association
Association Membership(s) (3)：
日本癌学会 ,  日本分子生物学会 ,  日本生化学会
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