Rchr
J-GLOBAL ID：200901077008313637   Update date: Nov. 15, 2024

Iwai Kazuhiro

イワイ カズヒロ | Iwai Kazuhiro
Affiliation and department：
Kyoto University Graduate School of Medicine

About Kyoto University Graduate School of Medicine


Homepage URL  (2)： http://www.mcp-kyoto-u.jp ,  http://www.med.kyoto-u.ac.jp/en/organization-staff/research/doctoral_course/r-004/
Research field  (4)： Pathobiochemistry ,  Medical biochemistry ,  Cell biology ,  Functional biochemistry
Research keywords  (4)： 包括脳ネットワーク ,  iron metabolism ,  NF-kB ,  ubiquitin
Research theme for competitive and other funds  (49)：
  • 2022 - 2027 Integrated analyses of LUBAC-mediated linear ubiquitination
  • 2022 - 2025 Involvement of linear ubiquitination in regulation of cancer and immunity
  • 2018 - 2023 New frontier for ubiquitin biology driven by chemo-technologies
  • 2018 - 2023 Functional regulation of ubiquitin chains using chemo-technologies
  • 2017 - 2022 Extensive analyses of the LUBAC ubiquitin ligase
Show all
Papers (185)：
  • Yusuke Toda, Hiroaki Fujita, Koshiki Mino, Takuto Koyama, Seiji Matsuoka, Toshie Kaizuka, Mari Agawa, Shigeyuki Matsumoto, Akiko Idei, Momoko Nishikori, et al. Synergistic involvement of the NZF domains of the LUBAC accessory subunits HOIL-1L and SHARPIN in the regulation of LUBAC function. Cell Death & Disease. 2024. 15. 11
  • Hiroaki Fujita, Yu-Ki Tanaka, Seiryo Ogata, Noriyuki Suzuki, Sota Kuno, Uladzimir Barayeu, Takaaki Akaike, Yasumitsu Ogra, Kazuhiro Iwai. PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis. Nature structural & molecular biology. 2024
  • Yukiko Takeda, Masahiro Ueki, Junpei Matsuhiro, Erik Walinda, Takayuki Tanaka, Masafumi Yamada, Hiroaki Fujita, Shunichiro Takezaki, Ichiro Kobayashi, Sakura Tamaki, et al. A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome. The Journal of experimental medicine. 2024. 221. 6
  • Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan/Pallavi Pimple/Pallavi Pimpale, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, et al. Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nature Immunology. 2024
  • Kentaro Akagi, Shiro Baba, Hiroaki Fujita, Yasuhiro Fuseya, Daisuke Yoshinaga, Hirohito Kubota, Eitaro Kume, Fumiaki Fukumura, Koichi Matsuda, Takayuki Tanaka, et al. HOIL-1L deficiency induces cell cycle alteration which causes immaturity of skeletal muscle and cardiomyocytes. Scientific reports. 2024. 14. 1. 8871-8871
ｍore...
MISC (31)：
  • Koji Jimbo, Shuhei Koide, Takahiro Ito, Arinobu Tojo, Katsuhiro Sasaki, Kazuhiro Iwai, Atsushi Iwama, Yasuhito Nannya, Takaaki Konuma. Deficiency of the E3 Ligase Hoip Impairs Adult Hematopoiesis and Myeloid Leukemia. BLOOD. 2021. 138
  • 植木 将弘, 松廣 淳平, 竹崎 俊一郎, 藤田 宏明, 三宅 紀子, 戸澤 雄介, 山田 雅文, 小林 一郎, 松本 直通, 有賀 正, et al. 多彩な自己炎症性疾患を紐解く Linear ubiquitin assembly complexとOTULINによる炎症と細胞死の制御 OTULIN-related autoinflammatory syndrome患者の解析を通して. 日本小児リウマチ学会総会・学術集会プログラム・抄録集. 2019. 29回. 52-52
  • 徳永暉, 藤田宏明, WALINDA Erik, 大木出, 有吉眞理子, 杤尾豪人, 岩井一宏, 白川昌宏. 直鎖型ユビキチンリガーゼLUBACの安定化機構の構造基盤研究. 日本分子生物学会年会プログラム・要旨集(Web). 2018. 41st
  • Donna Alexandra MacDuff, Tiffany A. Reese, Megan T. Baldridge, Jacqueline M. Kimmey, Leslie A. Weiss, Christina Song, Timothy J. Nice, Javier Carrero, Marco Colonna, Brian T. Edelson, et al. Regulation of Inflammation, Innate Immunity and Intestinal Homeostasis by HOIL1. FASEB JOURNAL. 2017. 31
  • 小倉麻梨子, 齋尾智英, 内田毅, 田中秀明, 田中秀明, 栗栖源嗣, 栗栖源嗣, 岩井一宏, 石森浩一郎. ヘムを制御分子とする細胞内鉄濃度制御機構の構造化学的解明. 日本蛋白質科学会年会プログラム・要旨集. 2017. 17th
ｍore...
Patents (4)：
  • UBIQUITIN LIGASE HAVING LINEAR POLYUBIQUITINATIONACTIVITY AND USE THEREOF
  • UBIQUITIN LIGASE AND USE THEREOF
  • 新規なユビキチンリガーゼおよびその利用
  • 破骨細胞制御剤とそのスクリーニング方法
Lectures and oral presentations  (51)：
  • Linear ubiquitination an emerging regulator of inflammatory diseases and oncogenesis
    (NCI CCR Cancer Innovation Laboratory Seminar series 2023)
  • Regulation and function of LUBAC-mediated linear ubiquitination in immunity
    (The International Symposium in Tokyo 2022 “Ubiquitin New Frontier “ from Neo-Biology to Targeted Protein Degradation” 2022)
  • Unexpected regulation and function of LUBAC-mediated linear ubiquitination in immunity
    (The first OIST-Kyoto;University Join;Workshop “Challenges in;Biomedical Complexities” 2022)
  • Unexpected functions of HOIL-1L E3: regulation of LUBAC, glycogen metabolism and beyond
    (EMBO Workshop “Ubiquitin and ubiquitin-like proteins in health and disease” 2022)
  • Mechanisms underlying the formation and destabilization of the LUBAC ligase complex.
    (Cold Spring Harbor Asia Conference “Ubiquitin Family, Autophagy & Diseases” 2018)
ｍore...
Education (2)：
  • - 1992 Kyoto University
  • - 1985 Kyoto University Faculty of Medicine
Professional career (1)：
  • Doctor of Medical Science (Kyoto University)
Work history (10)：
  • 2022/10 - 現在 Kyoto University Provost/Executive Vice-President
  • 2012/04 - 現在 Graduate School of Medicine, Kyoto University Professor
  • 2018/10 - 2022/09 Kyoto University Graduate School of Medicine Dean
  • 2008/04 - 2012/03 大阪大学大学院・生命機能研究科/医学系研究科 教授
  • 2001/07 - 2008/03 Graduate School of Medicine, Osaka City University Professor
Show all
Committee career (2)：
  • 2019/11 - 現在 日本生化学会 理事
  • 2013 - 現在 日本鉄バイオサイエンス学会 理事
Awards (5)：
  • 2021/06 - The Japan Academy Japan Academy Prize
  • 2020/03 - The Uehara Memorial Foundation Uehara Prize
  • 2019/11 - Takeda Science Foundation Takeda Medical Prize
  • 2017/11 - Mochida Memorial Foundation for Medical and Pharmaceutical Research Academic Award of the Mochida Memorial Foundation
  • 2015/11 - The Japan Medical Association Medical Award of The Japan Medical Association
Association Membership(s) (4)：
日本鉄バイオサイエンス学会 ,  日本癌学会 ,  日本分子生物学会 ,  日本生化学会
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page

TOP

BOTTOM