Rchr
J-GLOBAL ID：200901077866493775
Update date: Nov. 12, 2024
Bonkobara Makoto
ボンコバラ マコト | Bonkobara Makoto
Affiliation and department：
Job title：
Professor
Research field (1)：
Veterinary medicine
Research keywords (4)：
Veterinary oncology
, Veterinary clinical pathology
, 免疫学
, 分子生物学
Research theme for competitive and other funds (21)：
- 2022 - 2025 Development of a novel therapeutic strategy for KIT mutation-positive canine mast cell tumor using molecular glue
- 2019 - 2022 肥満細胞腫のチロシンキナーゼ阻害剤耐性化における多様性の解析と個別化治療の構築
- 2018 - 2021 AIM expression, mutation and function in canine histiocytic sarcoma
- 2015 - 2018 The role of canine AIM in histiocytic sarcoma
- 2014 - 2017 Identification and clinical application of cancer stem cells derived from canine refractory cancers
- 2015 - 2017 Studies on the mechanisms and therapeutic approach for resistance of tyrosine kinase inhibitors in mast cell tumour
- 2013 - 2016 Molecular analysis and development of a DNA-testing method for erythrocyte blood group antigens
- 2014 - 2014 Establishment of detection system for canine circulating tumor cell
- 2012 - 2014 Analysis of oncogene addiction and development of molecular-targeted therapy for small animal tumours
- 2013 - 2013 Changes of DNA profile in canine granular tumor cells transformed to melanoma cells
- 2009 - 2011 Analysis of aberrantly activated receptor tyrosine kinase and development of molecular targeting therapy in small animals with malignancies.
- 2007 - 2008 Analysis of regulation on feline infectious peritonitis virus replication by RNA interference
- 2006 - 2007 Study for inhibitory regulation of auto reactive T-cell by DC-HIL
- 2004 - 2007 Studies on regulatory mechanism of Th1/Th2 cell differentiation by antigen presenting cell (APC) and onAPC-mediated immunotherapy
- 2004 - 2006 Analysis of onset mechanism of obesity and diabetes in cats and its application to veterinary medicine
- 2004 - 2005 Analysis for selective ubiquitination of host immune proteins by Bovine Herpes virus type4 proteins
- 2004 - 2005 Dectin-2プロモーターを利用したウシにおける新規DNAワクチン開発の研究
- 2004 - 2005 家畜の感染症に対する表皮ランゲルハンス細胞を標的としたDNAワクチンの開発
- 2003 - 2004 ウシにおける表皮ランゲルハンス細胞選択的DNAワクチンシステム構築の基礎研究
- 2003 - 2004 ウシにおける表皮ランゲルハンス細胞を標的とした新規DNAワクチン開発の基礎研究
- 2002 - 2004 イヌDectin-2プロモーターによる新しい抗腫瘍DNAワクチン開発の基礎研究
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Papers (89)：
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H. Sakuma, H. Tomiyasu, A. Tani, Y. Goto-Koshino, H. Tani, K. Ohno, H. Tsujimoto, M. Bonkobara, M. Okuda. Antitumor effects of inhibitors of ERK and Akt pathways in canine histiocytic sarcoma cell lines. The Veterinary Journal. 2024. 308. 106264-106264
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Fubuki Kunita, Chihiro Udagawa, Takeshi Inagaki, Hideto Suzuki, Makoto Bonkobara, Toshinori Omi. Population genetics for 18 short tandem repeat loci (Canine GenotypesTM Panel 2.1 Kit) of 150 unrelated dogs from three pure-bred groups in Japan. Legal medicine (Tokyo, Japan). 2024. 70. 102472-102472
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Hajime Asada, Akiyoshi Tani, Hiroki Sakuma, Miyuki Hirabayashi, Yuki Matsumoto, Kei Watanabe, Masaya Tsuboi, Shino Yoshida, Kei Harada, Takao Uchikai, et al. Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma. Scientific Reports. 2023. 13. 1
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Masanori Kobayashi, Moe Onozawa, Shiho Watanabe, Tomokazu Nagashima, Kyoichi Tamura, Yoshiaki Kubo, Akiko Ikeda, Kazuhiko Ochiai, Masaki Michishita, Makoto Bonkobara, et al. Establishment of a BRAF V595E-mutant canine prostate cancer cell line and the antitumor effects of MEK inhibitors against canine prostate cancer. Veterinary and comparative oncology. 2023
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Hiroyuki Tani, Ryo Miyamoto, Teruki Miyazaki, Shingo Oniki, Kyoichi Tamura, Makoto Bonkobara. A feline case of multiple myeloma treated with bortezomib. BMC veterinary research. 2022. 18. 1. 384-384
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MISC (15)：
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小林 正典, 大竹 陽奈, 齊藤 千祥, 長島 智和, 落合 和彦, 田村 恭一, 道下 正貴, 盆子原 誠, 堀 達也, 河上 栄一. 新規の犬前立腺癌細胞株CHP-2に対するRAF阻害剤GDC-0879の抗腫瘍活性. 日本獣医学会学術集会講演要旨集. 2019. 162回. 442-442
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小林正典, 渡部志歩, 田村恭一, 盆子原誠, 堀達也, 河上栄一. 犬前立腺癌細胞株に対するMEK阻害剤およびRAF/MEK阻害剤の抗腫瘍効果. 日本獣医学会学術集会講演要旨集. 2018. 161st. 411
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金岡 春央梨, 中村 知尋, 佐藤 茉水, 本田 安里紗, 矢口 雅美, 川上 翔太, 宇埜 友美子, 坂本 敦司, 呰上 大吾, 盆子原 誠, et al. ネコAB式血液型を担うCMAH遺伝子のジェノタイピング c.364C>T変異型ホモ接合体を有するAB型ネコの同定. 日本獣医学会学術集会講演要旨集. 2018. 161回. 438-438
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小林正典, 地主真実子, 地主真実子, 田村恭一, 盆子原誠, 堀達也, 河上栄一. 犬前立腺癌細胞株CHP-1細胞に対するBRAF阻害剤の有効性に関する研究. 日本獣医学会学術集会講演要旨集. 2017. 160th. 440
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近江 俊徳, 中澤 翔太, 宇田川 智野, 多田 尚美, 三井 寛子, 落合 和彦, 加藤 由比子, 呰上 大吾, 左向 敏紀, 筒井 敏彦, et al. CMAH遺伝子解析による猫AB式血液型の分子基盤. 日本獣医学会学術集会講演要旨集. 2017. 160回. 483-483
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Works (2)：
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Joint research on Keratinocyte specific secreted protein
2001 -
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Joint research on dendritic cell specific promoter
2001 -
Education (2)：
- - 1997 The University of Tokyo
- - 1993 Nippon Veterinary and Life Science University
Professional career (1)：
- PhD (The University of Tokyo)
Work history (6)：
- 2015/04 - 現在 Nippon Veterinary and Life Science University
- 2011/04 - 2015/03 Nippon Veterinary and Life Science University
- 2005/04 - 2011/03 日本獣医畜産大学講師
- 2000/10 - 2005/03 日本獣医畜産大学助手
- 1998 - 2001 Research Fellow, University of Texas Southwestern Medical Center at Dallas
- 1997 - 1998 東京大学大学院特定研究員
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Committee career (11)：
- 2020/05 - 現在 Veterinary and Comparative Oncology Editorial Board
- 2017 - 現在 The Veterinary Journal (London, UK) Advisory Board
- 2016/01 - 現在 Ambassador of International Canine Health Awards, The Kennel Club UK Ambassador
- 2014 - 現在 日本獣医学会 評議員
- 2009 - 現在 日本小動物獣医師会 学術顧問
- 2000 - 現在 獣医臨床病理学会 会員
- 1991 - 現在 日本獣医学会 会員
- 2013 - 2018 獣医臨床病理学会 理事
- 2014 - 2017 The Veterinary Journal (London, UK) Scientific Editor
- 2011 - 2013 The Veterinary Journal Advisory Board
- 1999 - The society for investigative dermatology 会員
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Awards (3)：
- 2010/04 - 日本獣医生命科学大学 梅野信吉賞
- 2001 - Albert M. Kligman Award(Society for investigative dermatology)
- 2000 - Dermatology Foundation 2000 Research Award
Association Membership(s) (3)：
THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER
, JAPANESE SOCIETY OF VETERENARY CLINICAL PATHOLOGY
, 日本獣医学会
