Yonehara Shin

ヨネハラシン | Yonehara Shin

Affiliation and department：
Homepage URL (1)： http://www.pharm.kyoto-u.ac.jp/Yonehara_Lab/Home_j.htm

Research field (3)： Immunology , Cell biology , Functional biochemistry

Research keywords (7)：免疫 , 発がん , 発生 , シグナル伝達 , 細胞死 , programed cell death , apoptosis

Research theme for competitive and other funds (41)：

2015 - 2017 caspase-8と10それぞれが阻害する二種類の新規細胞死の解析
2015 - 2017 Functional analysis of histone variants controlling cell proliferation
2014 - 2017 Mechanism of Fas-mediated inflammatory response against bacterial infection in vivo
2012 - 2014 A novel type of cell death in tetraploids with chromosomal aberrations
2010 - 2012 Molecular mechanism and physiological role of FLASH with pleiotropic activities

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Papers (231)：

Eri Takada, Kaori Okubo, Yoshiaki Yano, Keiko Iida, Masataka Someda, Akira Hirasawa, Shin Yonehara, Katsumi Matsuzaki. Molecular Mechanism of Apoptosis by Amyloid β-Protein Fibrils Formed on Neuronal Cells. ACS Chemical Neuroscience. 2020. 11. 5. 796-805
Someda M, Kuroki S, Miyachi H, Tachibana M, Yonehara S. Caspase-8, receptor-interacting protein kinase 1 (RIPK1), and RIPK3 regulate retinoic acid-induced cell differentiation and necroptosis. Cell death and differentiation. 2019
Chen J, Kuroki S, Someda M, Yonehara S. Interferon-γ induces the cell surface exposure of phosphatidylserine by activating the protein MLKL in the absence of caspase-8 activity. The Journal of biological chemistry. 2019. 294. 32. 11994-12006
Uchiyama R, Yonehara S, Taniguchi S, Ishido S, Ishii KJ, Tsutsui H. Inflammasome and Fas-Mediated IL-1β Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo. Journal of immunology (Baltimore, Md. : 1950). 2017. 199. 3. 1122-1130
T.Shibata, Y. Fujita, H. Ohno, Y. Suzuki, K. Hayashi, K. R. Komatsu, S. Kawasaki, K. Hidaka, S. Yonehara, H. Sugiyama, et al. Protein-driven RNA nanostructured devices that function in vitro and control mammalian cell fate. Nature Communications. 2017. 8. 1. 540

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MISC (76)：

染田真孝, 黒木俊介, 立花誠, 米原伸. Caspase-8はRIPK1とRIPK3を介してレチノイン酸が誘導するネクロプトーシスと細胞分化を制御する. 生命科学系学会合同年次大会. 2017. 2017年度. [3PT19-13(3P
Kyung-Kwon Lee, Shin Yonehara. Identification of a mechanism that couples multisite phosphorylation of Yes-associated protein (YAP) with transcriptional coactivation and regulation of apoptosis (vol 287, pg 9568, 2012). JOURNAL OF BIOLOGICAL CHEMISTRY. 2016. 291. 9. 4844-4845
Sakaguchi S, Kuroki S, Yonehara S. Novel types of programmed necrosis by IFN-γ in wild-type and caspase-8 KO mouse embryonic fibroblasts. The 13th International Student Seminar, Kyoto. 2015
A Kako, S Yonehara. Analysis of the funciton of FLASH/casp8ap2 in regulation of apoptotic and nonapoptotic cell deatrh. The 13th International Student Seminar, Kyoto. 2015
Yamamoto N, Fukuoka A, Ohshima N, Yonehara S. Fas-expressing natural helper cell induces hyper-production of IgE through direct interaction with B cells. Fas-expressing natural helper cell induces hyper-production of IgE through direct interaction with B cells. 2014

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Patents (1)：

Books (5)：

Death receptor Fas and autoimmune disease: from the original generation to therapeutic application of agonistic anti-Fas monoclonal antibody
Cytokine and Growth Factor Reviews,13, 393-402 2002
Effects of anti-Fas antibodies on lymphocytes and other organs : Preparation of original and new monoclonal antibocties and amelioration of systemic autoimmune disease
International Reviews of Immunology.,18/,329-345 1999
Discovery of Cell Surface Fas Antigen which Mediutes Apoptosis - Inducing Signals
RINSHOKEN 20 Years pp79-85 1995
細胞死を支配するFas抗原の発見
東京都臨床医学総合研究所創立20周年記念誌 pp79-85 1995
細胞死-アポプトーシス
科学, 64/6,371-379 1994

Lectures and oral presentations (43)：

Caspase-8 regulates not only Fas-mediated apoptosis but also necroptosis and cell differentiation in early embryos
(Seminar, The Research Institute for Biomedical Science and Graduate School of Biological Science 2016)
Specific Induction of Tumor Cell Death by Induced Knockdown of Particular Gene Expression
(The 13th Symposium of New Frontiers Laboratories, Toray Industries, Inc 2016)
細胞の死が支える生体の生と機能 ~自爆するための細胞表層レセプターの発見から多様なプログラム細胞死の解析について~
(洛友会東京支部秋の講演会 2015)
Caspase-8とRIPキナーゼが制御する細胞死と細胞分化
(第24回日本Cell Death学会学術集会 2015)
生命科学からみた老化と寿命
(国際高等研究所「老いを考える」第6回研究会 2015)

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Education (4)：

Professional career (1)：

Work history (15)：

2021/05 - 現在京都大学薬学研究科産学協同講座ナノバイオ医薬創成科学講座教授
2018/04 - 2021/04 京都大学薬学研究科寄附講座ナノバイオ医薬創成科学講座教授
2001/08 - 2018/03 Professor, Graduated School of Biostudies, Kyoto University
1994/04 - 2001/07 Professor, Institute for Virus Research, Kyoto University
1992/04 - 1994/03 Senior Researcher, Pharmaceutical Basic Research Laboratories, JT. Inc.

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Committee career (3)：

Awards (2)：

Association Membership(s) (5)：

日本分子生物学会 , 日本細胞生物学会 , 日本癌学会 , 日本生化学会 , 日本免疫学会

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