Research theme for competitive and other funds (53)：
2024 - 2028 Establishment of disease risk testing method for oral vesicles and development of prevention method
2022 - 2025 メンブレンベジクルを利用した多機能性ワクチンプラットフォームの開発
2021 - 2024 Acceleration of unexplored periodontal disease vaccine development by intranasal administration of bacterial membrane vesicles
2021 - 2024 Development of new antibacterial oral care agent for the elderly: Attempt from basic experiment to clinical practical use
2020 - 2023 Periodontopathic bacterial outer membrane vesicles: Biogenesis and relation to development of chronic inflammation and carcinogenesis
2020 - 2023 Development of oral biofilm-associated disease preventive agent targeting vesicle complex
2019 - 2022 Novel nano paticle vaccine | Biogenesis and medical application of outer membrane vesicles
2021 - 2022 Research on preventing oral mucosal infection of SARS-Cov2 by coffee
2021 - 2022 Development of novel zirconia preparations with antibacterial and antiviral activities
2018 - 2021 A challenge to establish a model for inducing carcinogenesis and thrombus formation by continuous endovascular inoculation of oral bacteria.
2018 - 2021 Development of a new effective oral care agent for the prevention of periodontal disease-related systemic diseases among the elderly
2017 - 2021 What is a healthy oral microbiome? Proposal of oral health indicators based on metabolic resilience
2020 - 2021 Development of a new zirconia product with the ability to inhibit oral biofilm formation
2017 - 2020 Antibacterial and oral malodour supressing effects of black cumin food materials and elucidation of these mechanisms
2016 - 2019 細胞内核酸、ナノファイバー、シャペロンによる病原性バイオフィルム形成の検討
2015 - 2018 Development of control system for periodontopathic biofilm using SspB peptide
2015 - 2018 Possibility antimicrobial gel to control of oral pathogens and prevent of systemic diseases among elderly
2014 - 2017 Immunopathology of outer membrane vesicles of periodontopathic bacteria
2014 - 2017 Metabolome analysis of oral biofilm: a possible risk assessment of oral diseases using oral microbiome metabolism
2016 - 2017 塩の複合菌口腔バイオフィルム形成への影響
2016 - 2017 乳製品摂取習慣による高齢者の口腔常在菌叢の改善に関する研究
2011 - 2016 Study on relations of the genes associate with biofilm formation and transmission from mothers to child in the major pathogen of human dental caries
2013 - 2015 Establishment of pathogenic oral biofilm regulation approach
2012 - 2015 Analysis of gram-positive/negative bacteria ratio and pathogenicity of oral biofilm
2012 - 2015 Oral bacterial control and prevention of systemic disease among elderly : effects and possible applications of oral antimicrobial gel
2010 - 2014 Metabolomic approach to oral biofilm and saliva: possible risk indicator for oral diseases
1991 - 1993 Development of the passive immunization for prevention of dental caries using B cell epitopes of PAc.
Microgravity and Oral Infectious Diseases
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Papers (121)：
Manami Kimijima, Naoki Narisawa, Tomoyo Nakagawa-Nakamura, Hidenobu Senpuku. Allelic Variation in gtfB-gtfC Region of Natural Variant of Streptococcus mutans Without Biofilm Formation. Bacteria. 2024. 3. 4. 369-378
Erika Yamashita, Shinichi Negishi, Jun Kikuta, Mami Shimizu, Hidenobu Senpuku. Effects of Improper Mechanical Force on the Production of Sonic Hedgehog, RANKL, and IL-6 in Human Periodontal Ligament Cells In Vitro. Dentistry journal. 2024. 12. 4
Itaru Suzuki, Toshikazu Uchiyama, Yasutoshi Ojima, Yuki Ogura, Haruka Sakazume, Chieko Taguchi, Masafumi Wakita, Masashiko Fukumoto, Satoshi Hirayama, Hidenobu Senpuku, et al. Effects of Droplet and Aerosol Reduction Dependent on the Usage of High-volume Intra-oral Suction during Dental Treatment. International Journal of Oral-Medical Sciences. 2023. 22. 1. 11-22
Koji Saito, Yuri Aono, Arata Watanabe, Tetsuro Kono, Tomomi Hashizume-Takizawa, Hiroyuki Okada, Yasuhiro Kosuge, Hidenobu Senpuku, John L. Waddington, Tadashi Saigusa. Lipopolysaccharides derived fromPorphyromonas gingivalisandEscherichia coli:differential and interactive effects on novelty-induced hyperlocomotion, blood cytokine levels and TRL4-related processes. PLOS ONE. 2023. Accept
Hidenobu Senpuku, Kazuhisa Yoshimura, Hideki Takai, Yutaka Maruoka, Erika Yamashita, Akira Tominaga, Yorimasa Ogata. Role of Macrophage Colony-Stimulating Factor for Staphylococcal Infection in the Oral Cavity. Journal of clinical medicine. 2023. 12. 18
- 1992 Nihon University Graduate School, Division of Dental Research Oral Surgery
1982 - 1988 Nihon University School of Dentistry at Matsudo Department of Dentistry
- 1988 Nihon University Faculty of Dentistry
Professional career (1)：
Doctor of Dentistry (Nihon University)
Work history (8)：
2021/04 - 現在 Nihon University School of Dentistry at Matsudo Department of Microbiology and Immunology Professor
2003/02 - 2021/03 National Institute of Infectious Diseases Department of Bacteriology I
2002/04 - 2003/01 国立感染症研究所 細菌第一部 主任研究官
1997/04 - 2002/03 National Institute of Infectious Diseases Department of Oral Health Chief Researcher
1997/04 - - Chief Researcher, Department of Oral Science,
1992/04 - 1997/03 National Institute of Health Department of Oral Science Researcher
1992/04 - - Researcher, Department of Oral Science,
Institute of Infectious Diseases
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Committee career (11)：
2022/09 - 現在 歯科基礎医学会 理事
2021/09 - 現在 日本バイオフィルム学会 理事
2021/08 - 現在 日本エイズ学会 代議員
2020/05 - 現在 日本口腔衛生学会 広報委員
2018/01 - 現在 日本細菌学会 評議員
2015/04 - 現在 日本バイオフィルム学会 評議員
2013/04 - 現在 歯科基礎医学会 評議員および代議員
2003/04 - 現在 神奈川県HIV歯科診療体制運営検討委員会 委員
2013/04 - 2020/12 BMC Oral Health Section Editor
2018/01 - 2020/03 日本細菌学会関東支部会 評議員
2009 - 2014 日本細菌学会 評議員
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Association Membership(s) (13)：
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, 国際歯科医学会
, 日本生化学会
, 日本感染症学会
, 日本細菌学会
, 歯科基礎医学会
, 日本免疫学会
, Japanese Society of Immunology
, Japanese Society for Bacteriology
, Japanese Biochemical Society
, Japanese Association for Oral Biology
, Japanese Association for Infections Disease
, International Association for Dental Research
