Kukita Akiko

2018 - 2019 破骨細胞の骨吸収を制御する新たなタンパク質の作用機序

2015 - 2018 Roles of bone metastatic mammary tumor cell-derived extracellular vesicles in osteoclast differentiation and function

2015 - 2018 Novel function of osteoclastogenesis and bone resorption by membrane trafficking regulatory molecule

2015 - 2017 Development of novel methods to regulate only papthologically activated osteoclasts: A novel Concept for the Osteoclast Activation

2014 - 2016 Osteoclastogenesis from embryonic macrophages: Novel cell fate analysis and regulation of bone metabolism

2012 - 2016 Screening for regulatory proteins of osteoclastogenesis with lentiviral shRNA library

2013 - 2015 Regulation of pathological bone destruction via transmembrane immune regulator Tim-3

2012 - 2014 Regulation of bone resorption by membrane reparing molecules: Live imaging of the specific fusion among osteoclast precursors

2012 - 2014 新規癌骨転移制御薬の開発:伝統的秘薬の有効成分であるNordihydroguaiaretic Acid (NDGA)による破骨細胞制御とヒト肺癌の骨転移阻止

2011 - 2011 Expression of WT1 natural ant-sense NA and osteoclastogenesis : A novel strategy for the regulation of bone destruction

2009 - 2011 Regulation of bone destruction by bone marrow mesenchymal stem cells : Development and application of the cell-surface marker specific to tissue stem cells

2009 - 2011 Regulation of inflammatory bone destruction by galectin 3 : Identification of the novel receptor and molecular histological research

2009 - 2011 Analysis of regulatory mechanism of bone destruction and inflammation in experimental periodontitis mediated by IL-27 receptor

2009 - 2011 膜ナノチューブによる前破骨細胞融合調節:融合制御分子細胞間流入と前破骨細胞の教育

2010 - 2010 受容体を介して鉄を取込んだ破骨細胞の強磁場による動態制御:新規骨吸収制御法の開発

2008 - 2009 コーヒーの成分の骨代謝及び関節炎への影響

2007 - 2008 モノクローナル抗体による骨疾患治療法開発のための基礎研究

2007 - 2008 Molecular Immunological and Morphological Analysis of Novel Cell-surface Molecules Regulating Bone Resorption

2007 - 2008 Analysis of the regulation of bone resorption and signaling by membrane proteins expressed in osteoclasts

2005 - 2006 Expression of OCZF directed by the cathepsin K promoter affects bone mass and osteoclast formation in Transgenic Mice.

2004 - 2006 Regulation of osteoclastogenesis by a novel surface membrane receptor-like molecule : Preparation of gene-deficient mice and molecular histological analysis

2003 - 2004 Preparation of knockout Mouse of a transregulatory fector, OCZF which is specifically expressed inosteoclasts

2002 - 2003 Osteoclast Differentiation initiated at late-stage of mitosisof progenitor cells : Molecular mechanism of divergence from cell cycle

2001 - 2002 The Study of The Mechanisms of Onset and Progression of Rapidly Dystructive Coxarthrosis

2001 - 2002 Functional analysis of transcriptional regulator induced by ODF in the signal transduction of formation and activation of osteoclasts

2001 - 2001 POZ-Znフィンガー型転写制御因子の細胞増殖抑制作用の解析

2000 - 2001 Novel cell surface Fusion Regulartory Molecule involved in osteoclastogenesis: Morphological analysis of precursor fusion

1999 - 2000 Role of a novel Zn finger transcriptional regulator involved in osteoclastogenesis

1997 - 1998 Mechanism of cell-cell fusion process specific for preosteoclasts : Establishment of precursor cell line and morphological & cell biological studies on the cell fusion.

1997 - 1998 Molecular analysis of the signal transducers expressed in the process of the differentiation into osteoclasts

1996 - 1996 破骨細胞分化の制御機構:癌抑制遺伝子WT1による分化調節に関する組織学的研究

1995 - 1995 破骨細胞分化の分子機構:造血細胞分化決定遺伝子の発現に関する組織学的研究

1995 - 1995 破骨細胞のシグナル伝達制御解明(G蛋白質を介するレセプターキナーゼ遺伝子の解析)

1994 - 1994 破骨細胞機能抗原の遺伝子単離と、骨改造における発現パターン変化の組織学的解析

1993 - 1993 破骨細胞に特異的な膜表面抗原遺伝子のクローニングとその機能と解析

1992 - 1992 骨芽細胞様株細胞が分泌する破骨細胞分化誘導因子の精製及びその遺伝子のクローニング

1991 - 1992 Pathogenesis of Autoimmune Adjuvant-induced arthritis related to Mycobacterial 65 Kd heat-shock protein

1990 - 1992 Development of the primary culture system for ameloblasts and establish of their cell lines.

1990 - 1990 エナメル芽細胞の分化における表面抗原のモノクローナル抗体による解析

破骨細胞の分化と骨吸収の制御機構に関する研究

Study on the function and differentiation of osteoclasts

Role of a transcription factor expressed in osteoclast