Rchr
J-GLOBAL ID：200901078764630570   Update date: Jan. 31, 2024

Hanaoka Fumio

ハナオカ フミオ | Hanaoka Fumio
Affiliation and department：
国立遺伝学研究所

About 国立遺伝学研究所


Job title： 所長
Research field  (4)： Pharmacology ,  Pharmaceuticals - health and biochemistry ,  Cell biology ,  Molecular biology
Research keywords  (6)： 細胞周期 ,  DNA修復 ,  DNA複製 ,  Cell cycle ,  DNA repair ,  DNA replication
Research theme for competitive and other funds  (68)：
  • 2017 - 2020 Studies on the molecular mechanisms to regulate the resumption of stalled replication by translesion synthesis at DNA damage sites
  • 2015 - 2018 Study on rapid and hypersensitive screening of chemical genotoxin using mammalian cells defective for DNA damage-response factors
  • 2015 - 2018 Functional analyses and development of inhibitors based on higher-order structure of translesion DNA polymerase eta
  • 2015 - 2018 Molecular epidemiology studies on rare genetic disorders and pediatric cancer cohorts associated with genome instability
  • 2010 - 2016 Replication, repair and transcription; coupling mechanisms and chromatin dynamics for genome integrity
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Papers (271)：
  • Jun-ichi Akagi, Masayuki Yokoi, Yumi Miyake, Tsuyoshi Shirai, Tomohiro Baba, Young-Man Cho, Fumio Hanaoka, Kaoru Sugasawa, Shigenori Iwai, Kumiko Ogawa. A formamidopyrimidine derivative from the deoxyguanosine adduct produced by food contaminant acrylamide induces DNA replication block and mutagenesis. Journal of Biological Chemistry. 2023. 299. 8. 105002-105002
  • Jinseok Kim, Chia-Lung Li, Xuemin Chen, Yanxiang Cui, Filip M. Golebiowski, Huaibin Wang, Fumio Hanaoka, Kaoru Sugasawa, Wei Yang. Lesion recognition by XPC, TFIIH and XPA in DNA excision repair. Nature. 2023. 617. 7959. 170-175
  • Takeshi Mizuno, Kei Hirabayashi, Sae Miyazawa, Yurika Kobayashi, Kenta Shoji, Masakazu Kobayashi, Fumio Hanaoka, Naoko Imamoto, Hidetaka Torigoe. The intrinsically disordered N-terminal region of mouse DNA polymerase alpha mediates its interaction with POT1a/b at telomeres. Genes to Cells. 2021. 26. 6. 360-380
  • Wataru Sakai, Mayumi Yuasa-Sunagawa, Masayuki Kusakabe, Aiko Kishimoto, Takeshi Matsui, Yuki Kaneko, Jun-Ichi Akagi, Nicolas Huyghe, Masae Ikura, Tsuyoshi Ikura, et al. Functional impacts of the ubiquitin-proteasome system on DNA damage recognition in global genome nucleotide excision repair. Scientific reports. 2020. 10. 1. 19704-19704
  • Jun-Ichi Akagi, Keiji Hashimoto, Kenji Suzuki, Masayuki Yokoi, Niels de Wind, Shigenori Iwai, Haruo Ohmori, Masaaki Moriya, Fumio Hanaoka. Effect of sequence context on Polζ-dependent error-prone extension past (6-4) photoproducts. DNA repair. 2019. 87. 102771-102771
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MISC (623)：
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Patents (1)：
  • Method for specifically amplifying a dystroglycan, α-sarcoglycan, or endothelin B receptor cDNA of an extremely small quantity
Books (1)：
  • Shimizu, Y., Iwai, S., Hanaoka, F., and Sugasawa, K. Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase.
    <i>EMBO J.</i> 2003
Education (4)：
  • - 1973 東京大学大学院 薬学系研究科 製薬化学
  • - 1973 Graduate School, University of Tokyo Graduate School, Division of Pharmaceutical Sciences
  • - 1968 The University of Tokyo Faculty of Pharmaceutical Sciences
  • - 1968 University of Tokyo Faculty of Pharmaceutical Science
Professional career (1)：
  • Dr. Pharm. (The University of Tokyo)
Work history (6)：
  • RIKEN(The Institute of Physical and Chemical Research) Cellular Physiology Laboratory Director
  • 理化学研究所細胞生理学研究室主任研究員
  • 大阪大学細胞生体工学センター教授
  • Chief Scientist, Director of Cellular Physiology Lab. RIKEN
  • Osaka University
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Committee career (3)：
  • 1997 - 1999 日本分子生物学会 会計幹事、集会幹事、評議員
  • 1992 - 1997 日本細胞生物学会 会計幹事、運営委員、会計監査、運営委員
  • 1989 - 日本生化学会 評議員
Awards (2)：
  • 1989 - 日本薬学奨励賞
  • Award for Young Scientist of Pharmaceutical society of Japan
Association Membership(s) (7)：
日本細胞生物学会 ,  日本分子生物学会 ,  日本生化学会 ,  日本癌学会 ,  The Molecular Biology Society of Japan ,  The Japanese Biochemical Society ,  Japanese Cancer Association
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