Arai Fumio

アライフミオ | Arai Fumio

Affiliation and department：
Job title：教授

Research field (1)： Hematology and oncology

Research theme for competitive and other funds (18)：

2020 - 2023 Identification of transcriptional signaling networks that control the quality and quantity of the bone marrow microenvironment
2020 - 2023 シェルタリン因子による造血微小環境(ニッチ)の機能制御メカニズムの解明
2019 - 2021 Functional elucidation of shelterin factor TIN2 in leukemic stem cells and its application to the development of novel therapeutic strategies
2019 - 2021 シェルタリン因子を用いた造血幹細胞の機能再生と増幅系の確立
2017 - 2020 Elucidation of the mechanism of asymmetric division of hematopoietic stem cells using the next-generation artificial niche

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Papers (97)：

Kentaro Nakashima, Yuya Kunisaki, Kentaro Hosokawa, Kazuhito Gotoh, Hisayuki Yao, Ryosuke Yuta, Yuichiro Semba, Jumpei Nogami, Yoshikane Kikushige, Patrick S Stumpf, et al. POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis. Communications biology. 2023. 6. 1. 996-996
Sahoko Matsuoka, Raffaella Facchini, Tiago C Luis, Joana Carrelha, Petter S Woll, Takuo Mizukami, Bishan Wu, Hanane Boukarabila, Mario Buono, Ruggiero Norfo, et al. Loss of endothelial membrane KIT Ligand affects systemic KIT ligand levels but not bone marrow hematopoietic stem cells. Blood. 2023
Keiyo Takubo, Phyo Wai Htun, Takeshi Ueda, Yasuyuki Sera, Masayuki Iwasaki, Miho Koizumi, Kohei Shiroshita, Hiroshi Kobayashi, Miho Haraguchi, Shintaro Watanuki, et al. MBTD1 preserves adult hematopoietic stem cell pool size and function. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 32. e2206860120
Yaeko Nakajima-Takagi, Motohiko Oshima, Junichiro Takano, Shuhei Koide, Naoki Itokawa, Shun Uemura, Masayuki Yamashita, Shohei Andoh, Kazumasa Aoyama, Yusuke Isshiki, et al. Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis. eLife. 2023. 12
Kenta Murakami, Nobuhiko Hamazaki, Norio Hamada, Go Nagamatsu, Ikuhiro Okamoto, Hiroshi Ohta, Yoshiaki Nosaka, Yukiko Ishikura, Tomoya S Kitajima, Yuichiro Semba, et al. Generation of functional oocytes from male mice in vitro. Nature. 2023. 615. 7954. 900-906

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MISC (62)：

Yasutaka Hayashi, Kimihito Cojin Kawabata, Yosuke Tanaka, Yasufumi Uehara, Shigeru Kiryu, Yasunori Ota, Yusuke Yoshioka, Yo Mabuchi, Tatsuki Sugiyama, Keiko Mikami, et al. Impaired Osteoblastic Differentiation of MSCs Suppresses Normal Hematopoiesis in MDS. BLOOD. 2020. 136
Takuji Yamauchi, Takeshi Masuda, Matthew C. Canver, Michael Seiler, Mohammad Shboul, Manami Maeda, Vivien Schoonenberg, Mitchel A. Cole, Claudio Macias-Trevino, Yuichiro Semba, et al. Genome-Wide CRISPR/Cas9 Screen Reveals That the Dcps Scavenger Decapping Enzyme Is Essential for AML Cell Survival. BLOOD. 2017. 130
Leukemic stem cells and their niche regulation. 2016. 73. 6. 703-709
Single cell analysis for stem cell research. 2016. 258. 4. 293-298
Kentaro Hosokawa, Ben D. MacArthur, Shigemasa Hanazawa, Toshio Suda, Fumio Arai. PROTECTION OF TELOMERES 1 (POT1) REGULATES HEMATOPOIETIC STEM CELL ACTIVITY DURING AGEING. EXPERIMENTAL HEMATOLOGY. 2015. 43. 9. S68-S68

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Lectures and oral presentations (13)：

Pot1 maintains hematopoietic stem cell activity under stress
(Japan Society for the Promotion of Science and National University of Singapore joint symposium 2016)
Introduction of hematopoietic stem cell niche
(ISEH 44th Annual Scientific Meeting 2015)
Role of Pot1 in the regulation of hematopoietic stem cell activity
(2015 US-Japan Meeting on Malignant Hematopoiesis and Stem Cells 2015)
Regulation of hematopoietic stem cells in the niche
(Hematopoietic Stem Cells VII. 2011)
Regulation of Hematopoietic Stem Cells in the Niche
(International Society of Inflammation and Regeneration 2011)

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Committee career (2)：

2019/10 - 2021/09 日本血液学会評議員
2017/05 - 幹細胞シンポジウム幹事

Association Membership(s) (5)：

International Society for Experimental Hematology , Stem Cell Research Symposium , American Society of Hematology , The Japanese Society of Hematology , International Society for Stem Cell Research

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