Rchr
J-GLOBAL ID：200901078970309346   Update date: Nov. 21, 2024

Kubo Yoshinao

クボ ヨシナオ | Kubo Yoshinao
Affiliation and department：
Nagasaki University Institute of Tropical Medicine

About Nagasaki University Institute of Tropical Medicine


Job title： Associate Professor
Research field  (1)： Virology
Research keywords  (3)： 甲殻類免疫 ,  レトロウイルス ,  retrovirus
Research theme for competitive and other funds  (19)：
  • 2024 - 2025 甲殻類抗体様蛋白質Dscamを用いた迅速診断法の開発
  • 2022 - 2025 Basic and clinical study of GILT function in pathogenesis of bacterial toxins
  • 2023 - 2024 甲殻類抗体の抗原に対する親和性・特異性を高める改良法の開発
  • 2022 - 2023 クルマエビ抗体様蛋白質Dscamを用いた診断法・治療法の事業化検証
  • 2021 - 2022 クルマエビ抗体様蛋白質Dscamを用いた診断法・治療法の開発
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Papers (61)：
  • Yoshinao Kubo, Manya Bakatumana Hans, Taisuke Nakamura, Hideki Hayashi. The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site. International Journal of Molecular Sciences. 2024. 25. 18. 9987-9987
  • Taisuke Nakamura, Mai Izumida, Manya Bakatumana Hans, Shuichi Suzuki, Kensuke Takahashi, Hideki Hayashi, Koya Ariyoshi, Yoshinao Kubo. Post-Transcriptional Induction of the Antiviral Host Factor GILT/IFI30 by Interferon Gamma. International Journal of Molecular Sciences. 2024. 25. 17. 9663-9663
  • Hideki Hayashi, Tak Wah Mak, Yoshimasa Tanaka, Yoshinao Kubo, Mai Izumida, Ryuji Urae, Toshifumi Matsuyama. Development of a highly sensitive platform for protein-protein interaction detection and regulation of T cell function. Proceedings of the National Academy of Sciences. 2024. 121. 33
  • Haruka Maeda, Nobuo Saito, Ataru Igarashi, Masayuki Ishida, Mayumi Terada, Shingo Masuda, Ryosuke Osawa, Naoto Hosokawa, Kei Nakashima, Hiroshi Kamura, et al. Effectiveness of primary series, first, and second booster vaccination of monovalent mRNA COVID-19 vaccines against symptomatic SARS-CoV-2 infections and severe diseases during the SARS-CoV-2 omicron BA.5 epidemic in Japan: vaccine effectiveness real-time surveillance for SARS-CoV-2 (VERSUS). Expert review of vaccines. 2024. 23. 1. 213-225
  • Yoshinao Kubo, Kiyoshi Yasui, Mai Izumida, Hideki Hayashi, Toshifumi Matsuyama. IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral Activity of γ-Interferon and IDO1 Restricts Retrovirus Infection by Autophagy Enhancement. Cells. 2022. 11. 14. 2240-2240
ｍore...
MISC (6)：
  • Tsukasa Igawa, Yoshinao Kubo, Katsura Kakoki, Naoki Yamamoto, Hideki Sakai. A PRELIMINARY SCREENING OF XENOTROPIC MURINE LEUKEMIA VIRUS-RELATED VIRUS IN JAPANESE PROSTATE CANCER PATIENTS. JOURNAL OF UROLOGY. 2011. 185. 4. E510-E510
  • Arifa S. Khan, Myra McClure, Yoshinao Kubo, Paul Jolicoeur. Xenotropic and other murine leukemia virus-related viruses in humans. Advances in Virology. 2011. 2011. 787394
  • Control of membrane fusion activity by the C-terminal tail of retroviral envelope glycoprotein. 2004. 6. 1-12
  • 佐藤 裕徳, 佐多 徹太郎, 武部 豊, 岡 慎一, 岩本 愛吉, 根岸 昌功, 山本 直樹, 久保 嘉直, 森内 浩幸, 大石 和徳. 「HIV感染症の変貌とその対策」. 長崎大学熱帯医学研究所共同研究報告集. 2003. 14. 67-68
  • Yoshinao Kubo. Possible origin of murine aids-inducing sequence. Leukemia. 1997. 11. 3. 163-166
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Patents (4)：
  • 蛋白質分子、ポリヌクレオチド、蛋白質分子の製造方法、方法及び検査方法
  • ウイルス感染症の予防または治療剤
  • Retrovirus-infection-inhibitor
  • レトロウイルス感染抑制剤
Books (1)：
  • Retroviral membrane fusions: regulation by proteolytic processing and cellular factors.
    Springer Press 2011
Lectures and oral presentations  (9)：
  • Unique mode of antiviral action of a marine alkaloid and sulfated polysaccharides against Ebola virus and SARS-CoV-2
    (国際熱帯医学会 2023)
  • 宿主防御因子GBP2によるEnv糖蛋白質切断阻害に対するマウス白血病ウイルスの回避機構
    (日本ウイルス学会学術集会 2022)
  • Ebola virus infection is inhibited by marine alkaloid
    (日本熱帯医学会学術集会 2021)
  • SARS-CoV-2 infection is inhibited by a marine alkaloid, lamerallin alpha 20-sulfate
    (日本熱帯医学会学術集会 2020)
  • Identification of novel gamma-interferon-inducible anti-retrovirus host factors
    (International Workshop on Retroviral Pathogenesis 2019)
ｍore...
Works (4)：
  • cystatin-Cは、どのようにしてCD4非依存性HIV感染を促進するのか?
    2010 - 2012
  • NIK-333によるヒト免疫不全症ウイルス感染の抑制
    2007 - 2009
  • Inhibition of human immunodeficiency virus infection by NIK-333
    2007 - 2009
  • HIVの増殖・変異の制御に関する研究
    2005 - 2008
Education (2)：
  • - 1995 Kyoto University
  • - 1995 Kyoto University Graduate School, Division of Medicine
Professional career (1)：
  • 博士(医学) (京都大学)
Work history (8)：
  • 2019 - 現在 Nagasaki University Institute of Tropical Medicine
  • 2017 - 2019 Nagasaki University
  • 2011 - 2017 Nagasaki University Graduate School of Biomedical Sciences
  • 2002 - 2011 Nagasaki University Research Field of Pathogenesis and Clinical Sciences, Institute of Tropical Medicine
  • 2002 - 2011 Assistant Professor,Research Field of Pathogenesis and Clinical Sciences,Institute of Tropical Medicine,Nagasaki University
Show all
Committee career (1)：
  • 2017/04 - 現在 長崎県教育委員会 高大連携推進委員会
Association Membership(s) (3)：
日本熱帯医学会 ,  日本エイズ学会 ,  日本ウイルス学会
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