Research field (3):
Polymer chemistry
, Biomaterials
, Biomedical engineering
Research keywords (4):
バイオマテリアル
, ドラッグデリバリーシステム
, Biomaterial
, Drug Delivery System
Research theme for competitive and other funds (25):
2020 - 2023 Elucidation of cerebral circulation by the use of polymeric MRI contrast agents
2017 - 2020 Rational design of poly(ethylene glycol) derivatives for reduction of antibody responses against poly(ethylene glycol)
2015 - 2017 New combination therapy against solid tumor.
2014 - 2017 A novel drug and contrast agent targeting to brain acute ischemic stroke.
2013 - 2017 Application of thermo-sensitive complex containing photothermal conversion molecule, fullerene to cancer therapy
2010 - 2012 Creation of polymeric contrast agent systems possessing multiple imaging modalities
2009 - 2010 高分子ミセルキャリヤーの免疫原性制御のためのインターフェース設計
2008 - 2010 Therapeutic effect of the polymeric micellar antineoplastic drugs infused convection-enhanced delivery against intracranial rat glioma models
1989 - 2010 高分子ミセルによる薬物ターゲティング
1989 - 2010 Drug Targeting with polymeric micelles
2008 - 2009 CED法と高分子ミセルキャリヤーを用いた新規脳腫瘍化学療法システム
2006 - 2007 高分子ナノミセルを用いた非生体材料由来心臓血管外科用接着剤の分子設計
2002 - 2007 高分子ミセルによる医療接着剤
2002 - 2007 Medical Adhesive using polymeric micelle
2002 - 2004 An in vivo gene expressing system induced by external thermal stimuli
2001 - 2003 Development of novel co-culture system of parenchymal cells and nonparenchymal cells on thermoresponsive polymer-grafted dish surfaces
1999 - 2001 Gene Delivery System Using Thermo-responsive Polymers
1997 - 1998 Analysis of interactions of polymeric micelles with cells
1996 - 1998 Development of temperature-responsive culture dishes which allow viable cell sheet recovery
1997 - 1997 高分子ミセル型抗ガン剤の転移抑制効果の評価
1993 - 1993 pH応答性を有する高分子ミセル型ドラッグの分子設計
1991 - 1991 高分子ミセル型抗がん剤のがんへのタ-ゲッティング
1990 - 1990 高分子ミセル型ポリメリックドラッグの設計
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Papers (161):
Satoshi Okada, Kai Nishimura, Qarri Ainaya, Kouichi Shiraishi, Sergey A. Anufriev, Igor B. Sivaev, Yoshinori Sakurai, Minoru Suzuki, Masayuki Yokoyama, Hiroyuki Nakamura. Development of a Gadolinium-Boron-Conjugated Albumin for MRI-Guided Neutron Capture Therapy. Molecular Pharmaceutics. 2023. 20. 12. 6311-6318
Osman B, Wang Z, Shiraishi K, Yokoyama M, Matsumura Y. Precipitation of Insoluble Fibrin in the Brains of Alzheimer’s Disease Model Mice. Journal of Blood Disorders. 2023. 10. 1. 1070-1070
Machi Suka, Takamasa Kido, Wataru Yoshioka, Eri Hachisuka, Hiroto Okoshi, Takashi Yamauchi, Hiroshi Hano, Takashi Okano, Masayuki Yokoyama, Hiroyuki Yanagisawa. Single intratracheal administration of cross-linked water-soluble acrylic acid polymer causes acute alveolo-interstitial inflammation and the subsequent fibrotic formation possibly via the TGF-β1 pathway in the lung of rats. Toxicology. 2021. 448. 152647-152647
Solvent selection for research in laboratory. Drug delivery system : DDS : official journal of the Japan Society of Drug Delivery System. 2017. 32. 2. 150-152
Yusuke Sanada, Kouichi Shiraishi, Masayuki Yokoyama, Kazuo Sakurai. What is the major structural aspect to determine the blood circulation time for polymeric micelles. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2014. 247
- 1989 The University of Tokyo Graduate School, Division of Engineering Synthetic Chemistry
- 1984 The University of Tokyo The Faculty of Engineering
- 1984 The University of Tokyo Faculty of Engineering Department of Synthetic Chemistry
Professional career (1):
Ph.D (The University of Tokyo)
Work history (6):
2001 - 2004 Tokyo Women's Medical University
2001 - 2004 Associate Professor, Tokyo Women's Medical University
2004 - - 神奈川科学技術アカデミー、プロジェクトリーダー
2004 - - Project leader
1989 - 2001 Tokyo Women's Medical University
1989 - 2001 Assistant Professor, Tokyo Women's Medical University
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Committee career (6):
1998 - 2006 日本人工臓器学会 評議員
1998 - 2006 日本バイオマテリアル学会 評議員
1998 - 2006 Japanese Society for Artificial Organs Council Member
1998 - 2006 Japanese Society for Biomaterials Council Member
1996 - 2006 日本DDS学会 評議員
1996 - 2006 Japanese Society for DDS Council member
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Awards (6):
2003 - 日本DDS学会永井賞
2003 - Nagai Award
2002 - 日本人2臓器学会 論文賞
2002 - Best Paper Award
1996 - CRS 薬学最高発表賞
1996 - CRS Outstanding Pharmaceutical Paper Award
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Association Membership(s) (11):
日本人工臓器学会
, 日本化学会
, 日本バイオマテリアル学会
, 日本DDS学会
, 高分子学会
, Japanese Society for Artificial Organs
, Japanese Chemical Society
, Japanese Society for Biomaterials
, Japanese Society for DDS
, JAPAN
, Polymer Society