Research keywords (10)：
Mechanisms of general anesthetic action
, Dopaminergic neuron
, Glutamatergic neuron (NMDA receptor)
, GABAergic neuron (GABA type A receptor)
, Substance P
, Brain microdialysis
, Electroencephalography and electromyography
, General anesthetic components/analgesia, immobility
, Descending pain modulatory system
, Nitrous oxide/Peripheral blood perfusion
Research theme for competitive and other funds (13)：
2024 - 2027 脳波・筋電位による創薬候補物質の有効性評価を活用した新規全身麻酔薬の開発
2021 - 2024 Development of a control method for depth of anesthesia and/or sedation applied to a selective dopamine receptor subtype ligand.
2018 - 2021 Development of a novel general anesthetic method of applying the enhancement of descending pain suppression system by stimulation of dopamine neurons of the nucleus accumbens
2012 - 2014 Development of a control method for depth of anesthesia and/or sedation applied to a selective dopamine receptor subtype ligand.
2011 - 2013 The elucidation of role of motor neurons or pain pathways of the spinal cord in analgesia, muscle reluxation, and immobility as general anesthetic factors
2008 - 2010 The role of substance P in analgesia and immobility induced by general anesthetic agents
2006 - 2007 Clarification of mechanisms of analgesia and immobility induced by general anesthesia, and exploration of new anesthetic methods
2001 - 2002 Regulation of dopamine transporter function and its role in neuronal diseases - Regulation by arachidonic acid.
2001 - 2002 The Role of GABA and Glutamate Neurons in General Anesthetic Action
1998 - 1999 The role of GABA neurons in general anesthesia: an in vivo microdialysis study
1994 - 1995 Studies on the effect of opioids on the output of several neurotransmitters
1994 - 1995 Studies of excitement actions of N-methyl-D-aspartate antagonists
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Papers (140)：
Yuka Kikuchi, Masahiro Irifune, Taiga Yoshinaka, Kana Oue, Tamayo Takahashi, Aya Oda, Hisanobu Kamio, Serika Imamura, Utaka Sasaki, Eiji Imado, et al. A Behavioral and Electroencephalographic Study of Anesthetic State Induced by MK-801 Combined with Haloperidol, Ketamine and Riluzole in Mice. Anesthesia and analgesia. 2024
Akari Mukai, Masahiro Irifune, Yoshitaka Shimizu, Mitsuru Doi, Yuka Kikuchi, Sotaro Katayama, Kana Oue, Mitsuhiro Yoshida, Yukio Ago, Yoshiyuki Okada, et al. N-methyl-d-aspartate receptors and glycinergic transmission, respectively, mediate muscle relaxation and immobility of pentobarbital in mice. Neuroscience letters. 2023. 802. 137175-137175
Aya Oda, Kana Oue, Yuki Oda, Shima Taguchi, Tamayo Takahashi, Akari Mukai, Mitsuru Doi, Yoshitaka Shimizu, Masahiro Irifune, Mitsuhiro Yoshida. Difficult intubation and postoperative aspiration pneumonia associated with Moebius syndrome: a case report. BMC anesthesiology. 2022. 22. 1. 316-316
Eiji Imado, Samnang Sun, Abrar Rizal Abawa, Takeru Tahara, Takahiro Kochi, Tran Ngoc Bao Huynh, Satoshi Asano, Shigeru Hasebe, Yoki Nakamura, Kazue Hisaoka-Nakashima, et al. Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation. Neurochemistry international. 2022. 160. 105415-105415
Takahiro Kochi, Yoki Nakamura, Simeng Ma, Suzuna Uemoto, Kazue Hisaoka-Nakashima, Masahiro Irifune, Norimitsu Morioka. Mirogabalin alleviates nociceptive hypersensitivity without causing sedation in a mouse model of post-traumatic trigeminal neuropathy. Behavioural Brain Research. 2022. 425. 113829-113829
