Takuwa Noriko

タクワノリコ | Takuwa Noriko

Affiliation and department：
Job title： Professor
Other affiliations (1)：

Former Institution /Organization Kanazawa University Graduate School of Medical Science Invited lecturer, Invited researcher

Research field (2)： Clinical pharmacy , Physiology

Research keywords (4)：病態生理 , がん血管新生 , スフィンゴ脂質メディエーター , Physiology Biochemistry

Research theme for competitive and other funds (16)：

2017 - 2020 Sphingolipid signaling in control of macrophage functional polarity
2014 - 2016 慢性炎症と臓器線維化に関わるスフィンゴ脂質シグナリングの解明と新規治療戦略
2011 - 2013 スフィンゴシン-1-リン酸情報伝達系による癌血管新生・血行転移・虚血後血管新生の制御
2008 - 2010 スフィンゴシン-1-リン酸情報伝達系の生体における病態生理学的役割の解明
2006 - 2007 癌抑制G蛋白共役型受容体S1P2の作用機構の研究

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Papers (36)：

Pham HQ, Yoshioka K, Mohri H, Nakata H, Aki S, Ishimaru K, Takuwa N, Takuwa Y. MTMR4, a phosphoinositide-specific 3'-phosphatase, regulates TFEB activity and the endocytic and autophagic pathways. Genes Cells. 2018. doi: 10.1111/gtc.12609
Zhao J, Okamoto Y, Asano Y, Ishimaru K, Aki S, Yoshioka K, Takuwa N, Wada T, Inagaki Y, Takahashi C, et al. Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages. Zhao J, Okamoto Y, Asano Y, Ishimaru K, Aki S, Yoshioka K, Takuwa N, Wada T, Inagaki Y, Takahashi C, Nishiuchi T, Takuwa Y. 2018. 13. 5. e0197604. doi: 10.1371/journal
Sei-ichiro Ohkura, Soichiro Usui, Shin-ichiro Takashima, Noriko Takuwa, Kazuaki Yoshioka, Yasuo Okamoto, Yutaka Inagaki, Naotoshi Sugimoto, Teppei Kitano, Masayuki Takamura, et al. Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6. PLOS ONE. 2017. 12. 8. e0182329. doi: 10.1371/journal
Sho Aki, Kazuaki Yoshioka, Yasuo Okamoto, Noriko Takuwa, Yoh Takuwa. Phosphatidylinositol 3-Kinase Class II alpha-Isoform PI3K-C2 alpha Is Required for Transforming Growth Factor beta-induced Smad Signaling in Endothelial Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 2015. 290. 10. 6086-6105
Hong Cui, Yasuo Okamoto, Kazuaki Yoshioka, Wa Du, Noriko Takuwa, Wei Zhang, Masahide Asano, Toshishige Shibamoto, Yoh Takuwa. Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice. Journal of Allergy and Clinical Immunology. 2013. 132. 5. 1205-e9

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MISC (78)：

Yasuo Okamoto, Fei Wang, Kazuaki Yoshioka, Noriko Takuwa, Yoh Takuwa. Sphingosine-1-phosphate-specific G protein-coupled receptors as novel therapeutic targets for atherosclerosis. Pharmaceuticals. 2011. 4. 1. 117-137
Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1---Jekyll Hidden behind Hyde. Am J Cancer Res. 2011. 1. 4. 460-481
Role of sphingosine-1-phosphate signaling in atherosclerosis. LYSOPHOSPHOLIPID RECEPTORS: SIGNALING AND BIOCHEMISTRY. 2011
Fei Wang, Yasuo Okamoto, Isao Inoki, Kazuaki Yoshioka, Wa Du, Xun Qi, Noriko Takuwa, Koichi Gonda, Yasuhiko Yamamoto, Ryunosuke Ohkawa, et al. Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice (Retracted article. See vol. 122, pg. 1131, 2012). JOURNAL OF CLINICAL INVESTIGATION. 2010. 120. 11. 3979-3995
Xun Qi, Yasuo Okamoto, Tomomi Murakawa, Fei Wang, Osamu Oyama, Ryunosuke Ohkawa, Kazuaki Yoshioka, Wa Du, Naotoshi Sugimoto, Yutaka Yatomi, et al. Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice. EUROPEAN JOURNAL OF PHARMACOLOGY. 2010. 634. 1-3. 121-131

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Books (2)：

なるほどなっとく!解剖生理学
南山堂 2017
Bioactive Lipid Mediators: Current Reviews and Protocols.
Springer Japan 2015

Education (3)：

- 1989 医学博士(東京大学:論文博士)
- 1979 The University of Tokyo Faculty of Medicine School of Medicine
- 1979 The University of Tokyo Faculty of Medicine

Professional career (1)：

M.D., Ph.D. (The University of Tokyo)

Work history (7)：

2006 - 現在 Ishikawa Prefectural Nursing University Ishikawa Prefectural Nursing University
1999 - 2006 Kanazawa University
1987 - 1999 The University of Tokyo Faculty of Medicine
1985 - 1987 Yale大学客員研究員
1983 - 1985 The University of Tokyo Faculty of Medicine

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Committee career (3)：

2017/10 - 現在日本学術会議会員
2012/04 - 2016/03 日本生理学会副理事長・編集広報委員長・日本生理学雑誌編集長
1990 - 日本生理学会評議員

Awards (5)：

2001 - 蓬庵社医学研究助成金
1994 - 金原一郎記念基礎医学医療研究助成金
1993 - 内藤記念科学振興財団研究助成金
1988 - 武田科学振興財団研究助成金
1987 - 田中記念医学研究助成金

Association Membership(s) (7)：

日本看護科学会 , JAPANESE SOCIETY OF PATHOPHYSIOLOGY , THE JAPANESE CONFERENCE ON THE BIOCHEMISTRY OF LIPIDS , 日本循環器学会 , 日本生化学会 , 日本生理学会 , Federation of American Society of Experimental Biology

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